Alphostatin, an inhibitor of alkaline phosphatase of bovine liver produced by Bacillus megaterium.

phosphatase and esterase were located not only in cells but also on the cellular membrane of various kinds of mammalian cells1"40. We have succeeded in obtaining inhibitors against these enzymes from culture filtrates of the actinomycetes, bestatin, amastatin, forphenicine, esterastin, ebelactones A and B and so forth5~9). Among these inhibitors, bestatin, amastatin, forphenicine, ebelactones A and B enhanced immune responses, but esterastin suppressed immune responses10'115. These inhibitors were

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