Oxygen embolization during deep hypothermia.

The recent application in man of deep hypothermia and circulatory arrest without an extracorporeal oxygenator15was followed by reports of brain damage in children undergoing this procedure.3The mechanism of this complication has not been elucidated. It has been suggested that gas solubility is perhaps the major practical consideration as far as temperature effects in the blood are concerned because during rapid cooling and rewarming, the great temperature difference could result in gas embolism (Fig. 1). These facts led to the experimental use in dogs of continuous extracorporeal oxygenation and circulation during deep hypothermia with arterial blood of high oxygen tension at relatively high flow rates. This experimental model was devised so that the animals would be subjected to extreme conditions which theoretically should result in gas embolization. Method Ten dogs weighing between 14.1 and 19.8 kg. were anesthetized with intravenous sodium pentobarbital (25 mg. per kilogram) and

[1]  B. Meyer,et al.  Open-heart surgery using deep hypothermia without an oxygenator. , 1960, The Journal of thoracic and cardiovascular surgery.

[2]  Viking Olov BjöUrk.  AN EFFECTIVE BLOOD HEAT EXCHANGER FOR DEEP HYPOTHERMIA IN ASSOCIATION WITH EXTRACORPOREAL CIRCULATION BUT EXCLUDING THE OXYGENATOR , 1960 .

[3]  L. Luddington,et al.  Deep hypothermia for intracardiac surgery. Experimental and clinical use without an oxygenator. , 1960, American journal of surgery.

[4]  C. Drew.  Profound hypothermia in cardiac surgery. , 1960, The Medical annual.

[5]  L. C. Clark,et al.  Monitor and control of blood oxygen tension and pH during total body perfusion. , 1958, The Journal of thoracic surgery.

[6]  Brown Iw,et al.  An efficient blood heat exchanger for use with extracorporeal circulation. , 1958 .

[7]  L. Clark.  Optimal flow rate in perfusion , 1958 .

[8]  E. Wood,et al.  Cardiac output and related measurements and pressure values in the right heart and associated vessels, together with an analysis of the hemo-dynamic response to the inhalation of high oxygen mixtures in healthy subjects. , 1958, The Journal of laboratory and clinical medicine.

[9]  L. C. Clark,et al.  A comparison of the results of total body perfusion in dogs during potassium citrate cardiac arrest, sinus rhythm, and induced ventricular fibrillation. , 1958, Surgery.

[10]  J. Severinghaus,et al.  Alveolar dead space and arterial to end-tidal carbon dioxide differences during hypothermia in dog and man. , 1957, Journal of applied physiology.

[11]  J. Severinghaus,et al.  Effect of temperature on PCO2 and PO2 of blood in vitro. , 1956, Journal of applied physiology.

[12]  J. Severinghaus,et al.  Accuracy of blood pH and PCO2 determinations. , 1956, Journal of applied physiology.

[13]  J. Severinghaus,et al.  Variations of serum carbonic acid pK with pH and temperature. , 1956, Journal of applied physiology.

[14]  L. C. Clark,et al.  Thermometer for measuring body temperature in hypothermia. , 1954, Journal of the American Medical Association.

[15]  T. Rosenthal.  The effect of temperature on the pH of blood and plasma in vitro. , 1948, The Journal of biological chemistry.