Morbillivirus Control of the Interferon Response : Relevance of STAT 2 and mda 5 1 but not STAT 1 for Canine Distemper Virus Virulence in Ferrets 2 3

Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 1 but not STAT1 for Canine Distemper Virus Virulence in Ferrets 2 3 Nicholas Svitek, Ingo Gerhauser, Christophe Goncalves, Elena Grabski, Marius 4 Döring, Ulrich Kalinke, Danielle E. Anderson, Roberto Cattaneo, and Veronika von 5 Messling* 6 7 INRS-Institut Armand-Frappier, University of Quebec, Laval, Quebec, Canada 8 Emerging Infectious Diseases Program, Duke-NUS Graduate Medical School Singapore 9 Department of Pathology, University of Veterinary Medicine, Hannover, Germany 10 Institute for Experimental Infection Research, TWINCORE,Centre for Experimental and 11 Clinical Infection Research, a joint venture between the Helmholtz-Centre for Infection 12 Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany 13 Department of Molecular Medicine and Virology and Gene Therapy Graduate Track, 14 Mayo Clinic College of Medicine, Rochester, Minnesota, USA 15 Veterinary Medicine Division, Paul-Ehrlich-Institute, Langen, Germany 16 17 18 Abstract: 187 words 19 Importance Statement: 123 words 20 Manuscript: 4002 words 21 22 JVI Accepts, published online ahead of print on 26 December 2013 J. Virol. doi:10.1128/JVI.03076-13 Copyright © 2013, American Society for Microbiology. All Rights Reserved.

[1]  M. Baron,et al.  Morbillivirus V Proteins Exhibit Multiple Mechanisms to Block Type 1 and Type 2 Interferon Signalling Pathways , 2013, PloS one.

[2]  C. Biron,et al.  Changing partners at the dance , 2013, JAK-STAT.

[3]  J. Casanova,et al.  Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes , 2012, Current Opinion in Immunology.

[4]  T. Kuiken,et al.  Early Target Cells of Measles Virus after Aerosol Infection of Non-Human Primates , 2011, PLoS pathogens.

[5]  R. Cattaneo,et al.  A Recombinant Measles Virus Unable To Antagonize STAT1 Function Cannot Control Inflammation and Is Attenuated in Rhesus Monkeys , 2010, Journal of Virology.

[6]  C. Horvath,et al.  Dissociation of Paramyxovirus Interferon Evasion Activities: Universal and Virus-Specific Requirements for Conserved V Protein Amino Acids in MDA5 Interference , 2010, Journal of Virology.

[7]  E. Peterhans,et al.  Two Domains of the V Protein of Virulent Canine Distemper Virus Selectively Inhibit STAT1 and STAT2 Nuclear Import , 2010, Journal of Virology.

[8]  R. Fagard,et al.  STAT1 and pathogens, not a friendly relationship , 2010, Biochimie.

[9]  C. Horvath,et al.  A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2 , 2009, Journal of Virology.

[10]  P. Vidalain,et al.  Inhibition of IFN-alpha/beta signaling by two discrete peptides within measles virus V protein that specifically bind STAT1 and STAT2. , 2009, Virology.

[11]  S. Goodbourn,et al.  Mechanism of mda-5 Inhibition by Paramyxovirus V Proteins , 2008, Journal of Virology.

[12]  W. Bellini,et al.  Adaptation to cell culture induces functional differences in measles virus proteins , 2008, Virology Journal.

[13]  K. Conzelmann,et al.  Measles Virus V Protein Is a Decoy Substrate for IκB Kinase α and Prevents Toll-Like Receptor 7/9-Mediated Interferon Induction , 2008, Journal of Virology.

[14]  V. von Messling,et al.  Region between the Canine Distemper Virus M and F Genes Modulates Virulence by Controlling Fusion Protein Expression , 2008, Journal of Virology.

[15]  C. Horvath,et al.  STAT2 Is a Primary Target for Measles Virus V Protein-Mediated Alpha/Beta Interferon Signaling Inhibition , 2008, Journal of Virology.

[16]  R. Cattaneo,et al.  Attenuation of V- or C-Defective Measles Viruses: Infection Control by the Inflammatory and Interferon Responses of Rhesus Monkeys , 2008, Journal of Virology.

[17]  R. Cattaneo,et al.  Tyrosine 110 in the measles virus phosphoprotein is required to block STAT1 phosphorylation. , 2007, Virology.

[18]  S. Goodbourn,et al.  mda-5, but not RIG-I, is a common target for paramyxovirus V proteins. , 2007, Virology.

[19]  V. von Messling,et al.  Early cytokine mRNA expression profiles predict Morbillivirus disease outcome in ferrets , 2007, Virology.

[20]  W. Moss,et al.  Global measles elimination , 2006, Nature Reviews Microbiology.

[21]  R. Cattaneo,et al.  Receptor (SLAM [CD150]) Recognition and the V Protein Sustain Swift Lymphocyte-Based Invasion of Mucosal Tissue and Lymphatic Organs by a Morbillivirus , 2006, Journal of Virology.

[22]  N. Zheng,et al.  Structure of DDB1 in Complex with a Paramyxovirus V Protein: Viral Hijack of a Propeller Cluster in Ubiquitin Ligase , 2006, Cell.

[23]  G. Kochs,et al.  The interferon response circuit: Induction and suppression by pathogenic viruses , 2005, Virology.

[24]  L. Platanias.  Mechanisms of type-I- and type-II-interferon-mediated signalling , 2005, Nature Reviews Immunology.

[25]  E. Zúñiga,et al.  Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. , 2005, Immunity.

[26]  S. Goodbourn,et al.  The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[27]  M. Takeda,et al.  Dissection of measles virus V protein in relation to its ability to block alpha/beta interferon signal transduction. , 2004, The Journal of general virology.

[28]  R. Cattaneo,et al.  Tropism illuminated: lymphocyte-based pathways blazed by lethal morbillivirus through the host immune system. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[29]  C. Horvath,et al.  STAT Protein Interference and Suppression of Cytokine Signal Transduction by Measles Virus V Protein , 2003, Journal of Virology.

[30]  Thomas D. Schmittgen,et al.  Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. , 2000, Analytical biochemistry.

[31]  L. Platanias,et al.  Activation of the p 38 Mitogen-activated Protein Kinase by Type I Interferons , 1999 .

[32]  D. Levy,et al.  Differential viral induction of distinct interferon‐α genes by positive feedback through interferon regulatory factor‐7 , 1998, The EMBO journal.

[33]  M. Billeter,et al.  Recombinant Measles Viruses with Mutations in the C, V, or F Gene Have Altered Growth Phenotypes In Vivo , 1998, Journal of Virology.

[34]  P. Smith,et al.  Measles incidence, case fatality, and delayed mortality in children with or without vitamin A supplementation in rural Ghana. , 1997, American journal of epidemiology.

[35]  R. Dagan,et al.  Severe complications of measles requiring intensive care in infants and young children. , 1995, Archives of pediatrics & adolescent medicine.

[36]  R. Lamb,et al.  The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions. , 1995, Virology.

[37]  M. Billeter,et al.  Measles virus editing provides an additional cysteine-rich protein , 1989, Cell.

[38]  Sheila M. Thomas,et al.  Two mRNAs that differ by two nontemplated nucleotides encode the amino coterminal proteins P and V of the paramyxovirus SV5 , 1988, Cell.

[39]  C. Pirquet.  Das Verhalten der kutanen Tuberkulinreaktion während der Masern , 1908 .

[40]  Musheng Bao,et al.  Regulation of TLR7/9 signaling in plasmacytoid dendritic cells , 2012, Protein & Cell.

[41]  S. Schneider‐Schaulies,et al.  Measles virus-induced immunosuppression. , 2009, Current topics in microbiology and immunology.