Molecular Mechanisms of Vasodilatation

[1]  L. Ignarro,et al.  Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP. , 1984, The Journal of pharmacology and experimental therapeutics.

[2]  P. Kadowitz,et al.  Pulmonary Vasodilator Responses to Vagal Stimulation and Acetylcholine in the Cat , 1983, Circulation research.

[3]  J. Disalvo,et al.  Concentration and time-dependent relationships between isosorbide dinitrate-induced relaxation and formation of cyclic GMP in coronary arterial smooth muscle. , 1983, The Journal of pharmacology and experimental therapeutics.

[4]  J. Wikberg,et al.  Vascular smooth muscle relaxation by nitro compounds: reduced relaxation and cGMP elevation in tolerant vessels and reversal of tolerance by dithiothreitol. , 2009, Acta pharmacologica et toxicologica.

[5]  L. Ignarro,et al.  Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme. , 1982, The Journal of biological chemistry.

[6]  L. Ignarro,et al.  Purification and properties of heme-deficient hepatic soluble guanylate cyclase: effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX. , 1982, Archives of biochemistry and biophysics.

[7]  R. Smith,et al.  Nitroprusside Increases Cyclic Guanylate Monophosphate Concentrations during Relaxation of Rabbit Aortic Strips and Both Effects Are Antagonized by Cyanide , 1982, Anesthesiology.

[8]  L. Ignarro,et al.  Activation of purified guanylate cyclase by nitric oxide requires heme. Comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung. , 1982, Biochimica et biophysica acta.

[9]  R. Keith,et al.  Vascular tolerance to nitroglycerin and cyclic GMP generation in rat aortic smooth muscle. , 1982, The Journal of pharmacology and experimental therapeutics.

[10]  L. Ignarro,et al.  Activation of purified soluble guanylate cyclase by protoporphyrin IX. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[11]  L. Ignarro,et al.  Vasodilator actions of several N-nitroso compounds. , 1982, Canadian Journal of Physiology and Pharmacology.

[12]  L. Ignarro,et al.  Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin. , 1981, The Journal of pharmacology and experimental therapeutics.

[13]  L. Ignarro,et al.  Activation of hepatic guanylate cyclase by nitrosyl-heme complexes. Comparison of unpurified and partially purified enzyme. , 1981, Biochemical pharmacology.

[14]  G. Schultz,et al.  Soluble guanylate cyclase purified from bovine lung contains heme and copper , 1981, FEBS letters.

[15]  L. Ignarro,et al.  Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. , 1981, The Journal of pharmacology and experimental therapeutics.

[16]  G. Schultz,et al.  Purification of a soluble, sodium-nitroprusside-stimulated guanylate cyclase from bovine lung. , 1981, European journal of biochemistry.

[17]  L. Ignarro,et al.  Evidence that regulation of hepatic guanylate cyclase activity involves interactions between catalytic site -SH groups and both substrate and activator. , 1981, Archives of biochemistry and biophysics.

[18]  L. Ignarro,et al.  Pulmonary vasodilator responses to nitroprusside and nitroglycerin in the dog. , 1981, The Journal of clinical investigation.

[19]  L. Ignarro,et al.  Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite. , 1981, Canadian journal of physiology and pharmacology.

[20]  L. Ignarro,et al.  Selective alterations in responsiveness of guanylate cyclase to activation by nitroso compounds during enzyme purification. , 1981, Biochimica et biophysica acta.

[21]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[22]  L. Ignarro,et al.  Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols. , 1980, Biochimica et biophysica acta.

[23]  L. Ignarro,et al.  Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N'-nitrosonornicotine and nitric oxide. , 1980, The Journal of pharmacology and experimental therapeutics.

[24]  P. Armstrong,et al.  Absence of metabolite formation during nitroglycerin-induced relaxation of isolated blood vessels. , 1980, Molecular pharmacology.

[25]  L. Ignarro,et al.  Guanylate cyclase activation of nitroprusside and nitrosoguanidine is related to formation of S-nitrosothiol intermediates. , 1980, Biochemical and biophysical research communications.

[26]  L. Ignarro,et al.  Relaxation of bovine coronary arterial smooth muscle by cyclic GMP, cyclic AMP and analogs. , 1980, The Journal of pharmacology and experimental therapeutics.

[27]  L. Ignarro,et al.  Possible involvement of S‐nitrosothiols in the activation of guanylate cyclase by nitroso compounds , 1980, FEBS letters.

[28]  J. Diamond,et al.  Relationship between cyclic nucleotide levels and drug-induced relaxation of smooth muscle. , 1979, The Journal of pharmacology and experimental therapeutics.

[29]  A. Wurm,et al.  Prostacyclin increases cAMP in coronary arteries. , 1979, Journal of cyclic nucleotide research.

[30]  J. N. Wells,et al.  Effects of phosphodiesterase inhibitors on cyclic nucleotide levels and relaxation of pig coronary arteries. , 1979, Molecular pharmacology.

[31]  F. DeRubertis,et al.  Electron spin resonance study of the role of NO . catalase in the activation of guanylate cyclase by NaN3 and NH2OH. Modulation of enzyme responses by heme proteins and their nitrosyl derivatives. , 1979, The Journal of biological chemistry.

[32]  J. Wikberg,et al.  Relationship between nitroglycerin, cyclic GMP and relaxation of vascular smooth muscle. , 1979, Life sciences.

[33]  L. Ignarro,et al.  Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. , 1979, Journal of cyclic nucleotide research.

[34]  B. Robinson,et al.  Comparative dilator effect of verapamil and sodium nitroprusside in forearm arterial bed and dorsal hand veins in man: functional differences between vascular smooth muscle in arterioles and veins. , 1979, Cardiovascular research.

[35]  F. DeRubertis,et al.  Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation. , 1978, The Journal of biological chemistry.

[36]  E. Braunwald,et al.  Hemodynamic Effects of Intravenous Sodium Nitroprusside in the Conscious Dog , 1978, Circulation.

[37]  G. Carnahan,et al.  An unusually stable thionitrite from N-acetyl-D,L-penicillamine; X-ray crystal and molecular structure of 2-(acetylamino)-2-carboxy-1,1-dimethylethyl thionitrite , 1978 .

[38]  A. Wurm,et al.  Role of cyclic nucleotides in adenosine-mediated regulation of coronary flow. , 1978, Advances in cyclic nucleotide research.

[39]  F. Murad,et al.  Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin. , 1978, Advances in cyclic nucleotide research.

[40]  G. Schultz,et al.  Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets. , 1978, Advances in cyclic nucleotide research.

[41]  F. Murad,et al.  Cigarette smoke activates guanylate cyclase and increases guanosine 3',5'-monophosphate in tissues. , 1977, Science.

[42]  F. Murad,et al.  Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[43]  F. Murad,et al.  Purification and properties of a protein required for sodium azide activation of guanylate cyclase. , 1977, The Journal of biological chemistry.

[44]  J. Parratt,et al.  COMPARATIVE EFFECTS OF GLYCERYL TRINITRATE ON VENOUS AND ARTERIAL SMOOTH MUSCLE in vitro; RELEVANCE TO ANTIANGINAL ACTIVITY , 1977, British journal of pharmacology.

[45]  K. Kuriyama,et al.  Activation of cerebral guanylate cyclase by nitric oxide. , 1977, Biochemical and biophysical research communications.

[46]  F. Murad,et al.  Regulation of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate levels and contractility in bovine tracheal smooth muscle. , 1977, Molecular pharmacology.

[47]  G. Schultz,et al.  Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens , 1977, Nature.

[48]  F. Murad,et al.  Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. , 1977, Journal of cyclic nucleotide research.

[49]  F. DeRubertis,et al.  Calcium-independent modulation of cyclic GMP and activation of guanylate cyclase by nitrosamines. , 1976, Science.

[50]  J. Diamond,et al.  Effects of stimulant and relaxant drugs on tension and cyclic nucleotide levels in canine femoral artery. , 1976, Molecular pharmacology.

[51]  G. Schultz,et al.  CYCLIC NUCLEOTIDES AND SMOOTH MUSCLE FUNCTION , 1976 .

[52]  P. Needleman Organic nitrate metabolism. , 1976, Annual review of pharmacology and toxicology.

[53]  G. Neurath,et al.  Interaction of nitrogen oxides, oxygen and amines in gaseous mixtures. , 1976, IARC scientific publications.

[54]  J. Diamond,et al.  Effects of potassium chloride and smooth muscle relaxants on tension and cyclic nucleotide levels in rat myometrium. , 1975, Canadian journal of physiology and pharmacology.

[55]  F. Murad,et al.  Activation of guanylate cyclase from rat liver and other tissues by sodium azide. , 1975, The Journal of biological chemistry.

[56]  F. Murad,et al.  Increases in cyclic GMP levels in brain and liver with sodium azide an activator of guanylate cyclase , 1975, Nature.

[57]  V. Manganiello,et al.  Guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate content of human umbilical artery. , 1975, The Journal of clinical investigation.

[58]  F. Murad,et al.  Requirement for a macromolecular factor for sodium azide activation of guanulate cyclase. , 1975, Journal of cyclic nucleotide research.

[59]  J. Wikberg,et al.  Cyclic nucleotides and the contraction of smooth muscle. , 1975, Advances in cyclic nucleotide research.

[60]  M. Haddox,et al.  Alteration of vein cyclic 3':5' nucleotide concentrations during changes in contractility. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[61]  P. Needleman,et al.  Sulfhydryl requirement for relaxation of vascular smooth muscle. , 1973, The Journal of pharmacology and experimental therapeutics.

[62]  P. Needleman,et al.  Mechanism of tolerance development to organic nitrates. , 1973, The Journal of pharmacology and experimental therapeutics.

[63]  K. Austen,et al.  Asthma: physiology, immunopharmacology, and treatment , 1973 .

[64]  P. Greengard,et al.  Role of muscarinic cholinergic receptors in regulation of guanosine 3':5'-cyclic monophosphate content in mammalian brain, heart muscle, and intestinal smooth muscle. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[65]  G. P. Wheeler,et al.  Comparison of the effects of cysteine upon the decomposition of nitrosoureas and of 1-methyl-3-nitro-1-nitrosoguanidine. , 1972, Biochemical pharmacology.

[66]  T. Kawachi,et al.  The metabolism of N-methyl-N'-nitro-N-nitrosoguanidine in rats. , 1970, Biochimica et biophysica acta.

[67]  P. D. Lawley,et al.  Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation. , 1970, The Biochemical journal.

[68]  D. R. McCalla,et al.  Reactions of cysteine with N-methyl-N-nitroso-p-toluenesulfonamide and N-methyl-N′-nitro-N-nitrosoguanidine , 1969 .

[69]  D. R. McCalla,et al.  Inactivation of biologically active N-methyl-N-nitroso compounds in aqueous solution: effect of various conditions of pH and illumination. , 1968, Canadian journal of biochemistry.

[70]  R. Schoental,et al.  Interaction of N-alkyl-N-nitrosourethanes with thiols. , 1965, The Biochemical journal.

[71]  B. Saville A scheme for the colorimetric determination of microgram amounts of thiols , 1958 .

[72]  L. Heppel,et al.  METABOLISM OF INORGANIC NITRITE AND NITRATE ESTERS II. THE ENZYMATIC REDUCTION OF NITROGLYCERIN AND ERYTHRITOL TETRANITRATE BY GLUTATHIONE , 1950 .