Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: true supersaturation vs. apparent solubility enhancement.

[1]  M. Brandl,et al.  Impact of FaSSIF on the solubility and dissolution-/permeation rate of a poorly water-soluble compound. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[2]  A. Dahan,et al.  A win-win solution in oral delivery of lipophilic drugs: supersaturation via amorphous solid dispersions increases apparent solubility without sacrifice of intestinal membrane permeability. , 2012, Molecular pharmaceutics.

[3]  Claus-Michael Lehr,et al.  Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[4]  Stephen T Buckley,et al.  In vitro models to evaluate the permeability of poorly soluble drug entities: challenges and perspectives. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[5]  Songi Han,et al.  An ultrasensitive tool exploiting hydration dynamics to decipher weak lipid membrane-polymer interactions. , 2012, Journal of magnetic resonance.

[6]  M. Brandl,et al.  Effect of the non-ionic surfactant Poloxamer 188 on passive permeability of poorly soluble drugs across Caco-2 cell monolayers. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[7]  Z. A. Worku,et al.  Oral formulation strategies to improve solubility of poorly water-soluble drugs , 2011, Expert opinion on drug delivery.

[8]  Patrick Augustijns,et al.  The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate. , 2011, International journal of pharmaceutics.

[9]  M. Kuentz,et al.  The apparent solubilizing capacity of simulated intestinal fluids for poorly water-soluble drugs , 2011, Pharmaceutical development and technology.

[10]  Patrick Augustijns,et al.  Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica. , 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[11]  M. Brandl,et al.  In‐vitro permeability screening of melt extrudate formulations containing poorly water‐soluble drug compounds using the phospholipid vesicle‐based barrier , 2010, The Journal of pharmacy and pharmacology.

[12]  P. Holm,et al.  IVIVR in oral absorption for fenofibrate immediate release tablets using dissolution and dissolution permeation methods. , 2010, Die Pharmazie.

[13]  U. Kolb,et al.  IVIVC for fenofibrate immediate release tablets using solubility and permeability as in vitro predictors for pharmacokinetics. , 2010, Journal of pharmaceutical sciences.

[14]  Patrick Augustijns,et al.  Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[15]  G. Van den Mooter,et al.  Review: physical chemistry of solid dispersions. , 2009, The Journal of pharmacy and pharmacology.

[16]  G. Van den Mooter,et al.  Review: physical chemistry of solid dispersions , 2009 .

[17]  P. Kym,et al.  Analgesic potential of TRPV1 antagonists. , 2009, Biochemical pharmacology.

[18]  Patrick Augustijns,et al.  Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability? , 2009, Journal of pharmaceutical sciences.

[19]  B. Sarmento,et al.  Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. , 2007, Drug discovery today.

[20]  P. Artursson,et al.  Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers , 2007, Nature Protocols.

[21]  E. Lemp,et al.  Solubilization of dodac small unilamellar vesicles by sucrose esters : A fluorescence study , 2006 .

[22]  Stephen Hodge,et al.  A. Theoretical Basis , 2005 .

[23]  P Augustijns,et al.  Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers. , 2004, International journal of pharmaceutics.

[24]  J. Breitenbach.  Melt extrusion: from process to drug delivery technology. , 2002, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[25]  J Dressman,et al.  Improving drug solubility for oral delivery using solid dispersions. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[26]  J. Crison,et al.  A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability , 1995, Pharmaceutical Research.

[27]  W. H. Elliott,et al.  Data for Biochemical Research , 1986 .

[28]  Wagh Vinod Tukaram.  Solid Dispersions as Strategy to Improve Oral Bioavailability of Poor Water Soluble Drugs , 2013 .

[29]  K. Johnston,et al.  Effect of Stabilizer on the Maximum Degree and Extent of Supersaturation and Oral Absorption of Tacrolimus Made By Ultra-Rapid Freezing , 2007, Pharmaceutical Research.