Ropivacaína isolada ou associada à morfina, butorfanol ou tramadol pela via peridural em cadelas para realização de ovariosalpingohisterectomia

The aim of this study was to investigate the use of ropivacaine combined or not with different opioids, for epidural anesthesia in bitches submitted to elective ovariosalpingohisterectomy (OSH). Thirty two mixed-breed female dogs, adults were used with medium weigh of 10.5kg. The animals were premedicated with acepromazine (0.05mg.kg-1, IM) and midazolam (0.2mg.kg-1, IM) and allocated in four experimental groups: group 1(n=8): ropivacaine: 0.3 mL.kg-1; group 2(n=8): ropivacaine + morphine (0.1 mg.kg-1); group 3(n=8): ropivacaine + butorphanol (0.1 mg.kg-1); and group 4(n=8): ropivacaine + tramadol (0.5 mg.kg-1) administered epidurally. Heart and respiratory rate; systolic arterial pressure; rectal temperature; arterial blood gas partial pressures; blood pH; sedation and muscular relaxation degree were evaluated at different experimental moments. The data were submitted to ANOVA and compared by Kruskal Wallis, Friedman, Dunn, Tukey and Chi-square test (p≤0.05). Minimum cardiorespiratory alterations were observed and the group of the ropivacaine combined with the butorphanol (G3) presented a more cranial blockage, what allowed the accomplishment of OSH without induction in six animals (75%) whereas most of the others needed anesthetic rescue. The results allow us to conclude that the use of ropivacaine sole or combinated with morphine, butorphanol or tramadol, for epidural anesthesia, didn't promote significant cardiorrespiratory depression and the ropivacaine associated to the butorphanol allowed the accomplishment of OSH in bitches.

[1]  Vinita Singh,et al.  Efficacy of caudal butorphanol , 2006, Indian journal of pediatrics.

[2]  Luis Fernando Lima Castro,et al.  Estudo comparativo entre bupivacaína a 0,5%, mistura enantiomérica de bupivacaína (S75-R25) a 0,5% e ropivacaína a 0,75% associadas ao fentanil em anestesia peridural para cesarianas , 2003 .

[3]  Luis Vicente Garcia,et al.  Anestesia peridural contínua com ropivacaína a 0,2% associada a anestesia geral para cirurgia do abdômen superior em crianças , 2003 .

[4]  M. Mochizuki,et al.  Effects of medetomidine-midazolam, acepromazine-butorphanol, and midazolam-butorphanol on induction dose of thiopental and propofol and on cardiopulmonary changes in dogs. , 2002, American journal of veterinary research.

[5]  P. Pibarot,et al.  Results of preemptive epidural administration of morphine with or without bupivacaine in dogs and cats undergoing surgery: 265 cases (1997-1999). , 2002, Journal of the American Veterinary Medical Association.

[6]  N. Oleskovicz,et al.  Injeção epidural de morfina ou cetamina em cães: avaliação do efeito analgésico pelo emprego de filamentos de von Frey , 2002 .

[7]  José Reinaldo Cerqueira Braz,et al.  Efeitos da associação da clonidina à ropivacaína na anestesia peridural , 2002 .

[8]  K. Mama,et al.  Use of low doses of ketamine administered by constant rate infusion as an adjunct for postoperative analgesia in dogs. , 2002, Journal of the American Veterinary Medical Association.

[9]  C. Valadão,et al.  ADMINISTRAÇÃO EPIDURAL DE OPIÓIDES EM CÃES , 2002 .

[10]  Cláudio Corrêa Natalini,et al.  TRAMADOL VIA EPIDURAL EM CÃES SUBMETIDOS À SUBSTITUIÇÃO DO LIGAMENTO CRUZADO CRANIAL THE USE OF EPIDURAL TRAMADOL IN DOGS SUBMITTED TO CRANIAL CRUCIATE LIGAMENT REPLACEMENT , 2002 .

[11]  G. Edwards,et al.  Comparison of the effects of morphine administered by constant-rate intravenous infusion or intermittent intramuscular injection in dogs. , 2001, Journal of the American Veterinary Medical Association.

[12]  R. Jones,et al.  Epidural analgesia in the dog and cat. , 2001, Veterinary journal.

[13]  C. Natalini,et al.  Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. , 2000, American journal of veterinary research.

[14]  T. Duke,et al.  Comparative analgesic and cardiopulmonary effects of epidural bupivacaine and ropivacaine in conscious dogs. , 2000, Veterinary anaesthesia and analgesia.

[15]  D. Dyson,et al.  Epidural analgesia and anesthesia. , 2000, The Veterinary clinics of North America. Small animal practice.

[16]  J. Eichhorn,et al.  Visceral analgesic tolerance to intrathecal butorphanol in rats , 1998, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[17]  Herperger Lj POSTOPERATIVE URINARY RETENTION IN A DOG FOLLOWING MORPHINE WITH BUPIVACAINE EPIDURAL ANALGESIA , 1998 .

[18]  Cibele Andrucioli de Mattos Pimenta,et al.  Opiáceo intratecal na dor crônica não neoplásica: alívio e qualidade de vida , 1998 .

[19]  D. Dyson,et al.  End tidal halothane concentration and postoperative analgesia requirements in dogs: a comparison between intravenous oxymorphone and epidural bupivacaine alone and in combination with oxymorphone. , 1998, The Canadian veterinary journal = La revue veterinaire canadienne.

[20]  E. Grisneaux,et al.  Comparison of ketoprofen, oxymorphone hydrochloride, and butorphanol in the treatment of postoperative pain in dogs. , 1997, Journal of the American Veterinary Medical Association.

[21]  A. Waterman,et al.  Analgesia in cats , 1997, In Practice.

[22]  M. Schmitz,et al.  Caudal epidural butorphanol plus bupivacaine versus bupivacaine in pediatric outpatient genitourinary procedures. , 1997, Journal of clinical anesthesia.

[23]  M. Raffe,et al.  Epidural administration of bupivacaine, morphine, or their combination for postoperative analgesia in dogs. , 1996, Journal of the American Veterinary Medical Association.

[24]  M. James,et al.  Intravenous Tramadol Versus Epidural Morphine for Postthoracotomy Pain Relief: A Placebo-Controlled Double-Blind Trial , 1996, Anesthesia and analgesia.

[25]  H. Kehlet,et al.  Pharmacokinetics and Analgesic Effect of Ropivacaine during Continuous Epidural Infusion for Postoperative Pain Relief , 1996, Anesthesiology.

[26]  J. Thurmon,et al.  Lumb & Jones Veterinary Anesthesia , 1996 .

[27]  M. Flynn,et al.  Comparison of intra-articular and epidural morphine for analgesia following stifle arthrotomy in dogs. , 1995, Veterinary surgery : VS.

[28]  S. Alahuhta,et al.  The Effects of Epidural Ropivacaine and Bupivacaine for Cesarean Section on Uteroplacental and Fetal Circulation , 1995, Anesthesiology.

[29]  R. Keegan,et al.  Cardiovascular effects of epidurally administered morphine and a xylazine-morphine combination in isoflurane-anesthetized dogs. , 1995, American journal of veterinary research.

[30]  R. Taylor,et al.  Manual of Small Animal Postoperative Care , 1995 .

[31]  R. McMurphy,et al.  Postoperative epidural analgesia. , 1993, The Veterinary clinics of North America. Small animal practice.

[32]  A. Baraka,et al.  A comparison of epidural tramadol and epidural morphine for postoperative analgesia , 1993, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[33]  S. Chrubasik,et al.  The ideal epidural opioid--fact or fantasy? , 1993, European journal of anaesthesiology.

[34]  S. Datta,et al.  Does epidural administration of butorphanol offer any clinical advantage over the intravenous route? A double-blind, placebo-controlled trial. , 1992, Anesthesiology.

[35]  A. Valverde,et al.  Comparison of the hemodynamic effects of halothane alone and halothane combined with epidurally administered morphine for anesthesia in ventilated dogs. , 1991, American journal of veterinary research.

[36]  D. Sessler Shivering during epidural anesthesia. , 1990, Acta anaesthesiologica Scandinavica.

[37]  B. Covino,et al.  Comparative Motor‐Blocking Effects of Bupivacaine and Ropivacaine, A New Amino Amide Local Anesthetic, in the Rat and Dog , 1988, Anesthesia and analgesia.

[38]  B. Covino,et al.  Epidural Morphine Provides Postoperative Pain Relief in Peripheral Vascular and Orthopedic Surgical Patients: A Dose—Response Study , 1986, Anesthesia and analgesia.

[39]  Trim Cm Cardiopulmonary effects of butorphanol tartrate in dogs. , 1983, American journal of veterinary research.

[40]  N. Rawal,et al.  Postoperative Pain Relief by Epidural Morphine , 1981, Anesthesia and analgesia.

[41]  W. Muir Manual de anestesia veterinaria , 2008 .

[42]  Almir Pereira de Souza,et al.  Alterações eletrocardiográficas e cardiovasculares promovidas pela morfina ou butorfanol em cães anestesiados pelo desfluorano , 2004 .

[43]  S. R. G. Cortopassi,et al.  Anestesia em cães e gatos , 2002 .

[44]  S. R. G. Cortopassi,et al.  Medicação pré-anestésica , 2002 .

[45]  Márcia P. Galego,et al.  Utilização de analgésicos em pequenos animais , 2000 .

[46]  T. Duke,et al.  Comparative analgesic and cardiopulmonary effects of bupivacaine and ropivacaine in the epidural space of the conscious dog. , 2000, Veterinary anaesthesia and analgesia.

[47]  B. Benson,et al.  Prospective multicenter evaluation of tramadol exposure. , 1997, Journal of toxicology. Clinical toxicology.

[48]  B. Benson,et al.  Prospective multicenter evaluation of tramadol exposure. , 1997, Journal of toxicology. Clinical toxicology.

[49]  H. S. Spinosa,et al.  Tranqüilizantes e relaxantes musculares de ação central , 1996 .