MOLECULAR ANALYSIS AND PATHOLOGY OF A SECOND PEDIATRIC HIV-ASSOCIATED BURKITT LYMPHOMA

Diagnosis of a second HIV-associated non-Hodgkin lymphoma (HIV-NHL) is rare, but additional cases may occur as aggressive therapy for both HIV and NHL improves. An 11-year-old presented with a second primary HIV-NHL following remission for 9 years. Analysis of the tumor demonstrated presence of EBV and HIV with absence of CMV, HHV-8, and HHV-6. Although microscopic disease was present only in CSF, analysis of peripheral blood and bone marrow by PCR was positive. The patient underwent a stem cell transplant, but within 3 months, his disease recurred. Analysis for residual disease and viruses in similar cases may provide information in understanding pediatric HIV-NHL.

[1]  U. Tirelli,et al.  Impact of HAART on the clinical management of AIDS-related cancers. , 2001, European journal of cancer.

[2]  J. Romeu,et al.  Influence of highly active anti‐retroviral therapy on response to treatment and survival in patients with acquired immunodeficiency syndrome‐related non‐Hodgkin's lymphoma treated with cyclophosphamide, hydroxydoxorubicin, vincristine and prednisone , 2001, British journal of haematology.

[3]  H. Heslop,et al.  Allogeneic bone marrow transplantation in children failing prior autologous bone marrow transplantation , 2001, Bone Marrow Transplantation.

[4]  B. Pollock,et al.  Molecular and Virologic Characteristics of Lymphoid Malignancies in Children With AIDS , 2000, Journal of acquired immune deficiency syndromes.

[5]  D. Scadden,et al.  AIDS oncology. , 2000, Infectious disease clinics of North America.

[6]  B. Mueller.  HIV-associated malignancies in children. , 1999, AIDS patient care and STDs.

[7]  B. Pollock,et al.  Human herpesvirus‐8 (HHV‐8) associated with small non‐cleaved cell lymphoma in a child with AIDS , 1999, American journal of hematology.

[8]  J. Gribben,et al.  A novel nested-PCR strategy for the detection of rearranged immunoglobulin heavy-chain genes in B cell tumors , 1997, Leukemia.

[9]  V. Leblond,et al.  Autologous bone marrow transplantation in relapsed HIV-related non-Hodgkin's lymphoma. , 1996, Bone marrow transplantation.

[10]  S. Murphy,et al.  Cancers in children with HIV infection. , 1996, Hematology/oncology clinics of North America.

[11]  S. Swerdlow,et al.  A clonally distinct recurrence of Burkitt's lymphoma at 15 years. , 1996, Blood.

[12]  J. Downing,et al.  Non-Hodgkin's lymphoma in childhood. , 1996, The New England journal of medicine.

[13]  E. Cesarman,et al.  Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. , 1995, The New England journal of medicine.

[14]  N. Maitland,et al.  Detection of clonality in childhood B-lineage acute lymphoblastic leukaemia by the polymerase chain reaction. , 1992, Leukemia.

[15]  E. Jaffe,et al.  Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient. , 1988, Blood.