The obesity paradox in the elderly: potential mechanisms and clinical implications.

[1]  K. Flegal,et al.  Prevalence and trends in obesity among US adults, 1999-2008. , 2010, JAMA.

[2]  S. Jo,et al.  Adiposity parameters and cognitive function in the elderly: application of "Jolly Fat" hypothesis to cognition. , 2009, Archives of gerontology and geriatrics.

[3]  I. Janssen,et al.  Effect of Current and Midlife Obesity Status on Mortality Risk in the Elderly , 2008, Obesity.

[4]  D. Melzer,et al.  Obesity, Physical Function, and Mortality in Older Adults , 2008, Journal of the American Geriatrics Society.

[5]  F. Willekens,et al.  The burden of mortality of obesity at middle and old age is small. A life table analysis of the US Health and Retirement Survey , 2008, European Journal of Epidemiology.

[6]  K. Kario,et al.  Association of body mass index with cognitive function in elderly hypertensive Japanese. , 2008, American Journal of Hypertension.

[7]  G. Buhr,et al.  Is obesity bad for older persons? A systematic review of the pros and cons of weight reduction in later life. , 2008, Journal of the American Medical Directors Association.

[8]  Anne B. Newman,et al.  Weight, Mortality, Years of Healthy Life, and Active Life Expectancy in Older Adults , 2008, Journal of the American Geriatrics Society.

[9]  P. Whincup,et al.  Decreased muscle mass and increased central adiposity are independently related to mortality in older men. , 2007, The American journal of clinical nutrition.

[10]  J. Simon.  An intermediate body mass index (23 to 30 kg/m 2) was associated with the most favorable mortality in older women. , 2007, ACP journal club.

[11]  S. Anker,et al.  Risk factor paradox in wasting diseases , 2007, Current opinion in clinical nutrition and metabolic care.

[12]  S. Akifusa,et al.  Association Between Body Mass Index and Mortality in an 80‐Year‐Old Population , 2007, Journal of the American Geriatrics Society.

[13]  V. Froelicher,et al.  Body mass, fitness and survival in veteran patients: another obesity paradox? , 2007, The American journal of medicine.

[14]  J. Goodwin,et al.  The effect of obesity on disability vs mortality in older Americans. , 2007, Archives of internal medicine.

[15]  J. Sánchez-Payá,et al.  The role of the public health official in communicating public health information. , 2007, American journal of public health.

[16]  I. Janssen,et al.  Elevated body mass index and mortality risk in the elderly , 2007, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[17]  V. Tikhonoff,et al.  Body mass index and mortality in elderly men and women from general population. The experience of Cardiovascular Study in the Elderly (CASTEL). , 2007, Gerontology.

[18]  Ehud Grossman,et al.  Body Mass Index is Inversely Related to Mortality in Elderly Subjects , 2007, Journal of General Internal Medicine.

[19]  V. Tikhonoff,et al.  Body Mass Index and Mortality in Elderly Men and Women from General Population , 2006, Gerontology.

[20]  Rachel Hess,et al.  Obesity in Older Adults: A Systematic Review of the Evidence for Diagnosis and Treatment , 2006, Obesity.

[21]  P. Whincup,et al.  The relations of body composition and adiposity measures to ill health and physical disability in elderly men. , 2006, American journal of epidemiology.

[22]  Sun Ha Jee,et al.  Body-mass index and mortality in Korean men and women. , 2006, The New England journal of medicine.

[23]  Elizabeth Breeze,et al.  Weight, shape, and mortality risk in older persons: elevated waist-hip ratio, not high body mass index, is associated with a greater risk of death. , 2006, The American journal of clinical nutrition.

[24]  W. Nusselder,et al.  Adult Obesity and Number of Years Lived with and without Cardiovascular Disease , 2006, Obesity.

[25]  M. Pfeffer,et al.  AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update endorsed by the National Heart, Lung, and Blood Institute. , 2006, Journal of the American College of Cardiology.

[26]  C. Kawas,et al.  Association of body mass index and weight change with all-cause mortality in the elderly. , 2006, American journal of epidemiology.

[27]  K. Flegal,et al.  Prevalence of overweight and obesity in the United States, 1999-2004. , 2006, JAMA.

[28]  M. Heo,et al.  Depressive mood and obesity in US adults: comparison and moderation by sex, age, and race , 2006, International Journal of Obesity.

[29]  A. Dyer,et al.  Midlife body mass index and hospitalization and mortality in older age. , 2006, JAMA.

[30]  T. Harris,et al.  Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. , 2006, The New England journal of medicine.

[31]  Robert Ross,et al.  Body Mass Index Is Inversely Related to Mortality in Older People After Adjustment for Waist Circumference , 2005, Journal of the American Geriatrics Society.

[32]  Robert F Kushner,et al.  Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. , 2005, Obesity research.

[33]  T. Harris,et al.  Health consequences of obesity in the elderly: a review of four unresolved questions , 2005, International Journal of Obesity.

[34]  D. Grabowski,et al.  Obesity and mortality in elderly nursing home residents. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[35]  Yasuhiko Saito,et al.  The impact of obesity on active life expectancy in older American men and women. , 2005, The Gerontologist.

[36]  J. Shaw,et al.  Does high-intensity resistance training maintain bone mass during moderate weight loss in older overweight adults with type 2 diabetes? , 2005, Osteoporosis International.

[37]  Dejun Su.  Body mass index and old‐age survival: A comparative study between the Union Army Records and the NHANES‐I Epidemiological Follow‐Up Sample , 2005, American journal of human biology : the official journal of the Human Biology Council.

[38]  K. Kalantar-Zadeh,et al.  Reverse Epidemiology: A Spurious Hypothesis or a Hardcore Reality? , 2004, Blood Purification.

[39]  Arya M. Sharma,et al.  Obesity research in Canada: literature overview of the last 3 decades. , 2004, Obesity research.

[40]  S. Klein,et al.  Physical frailty and body composition in obese elderly men and women. , 2004, Obesity research.

[41]  M. Sevick,et al.  Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. , 2004, Arthritis and rheumatism.

[42]  L. DiPietro,et al.  Can physical activity attenuate aging-related weight loss in older people? The Yale Health and Aging Study, 1982-1994. , 2004, American journal of epidemiology.

[43]  R. Thorpe,et al.  Aging, Obesity, and Mortality , 2004, Research on aging.

[44]  A. Tjønneland,et al.  Waist circumference, BMI, smoking, and mortality in middle-aged men and women. , 2003, Obesity research.

[45]  A. Heiat.  Impact of age on definition of standards for ideal weight. , 2003, Preventive cardiology.

[46]  K. Kalantar-Zadeh,et al.  Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. , 2003, Kidney international.

[47]  D. Allison,et al.  Years of life lost due to obesity. , 2003, JAMA.

[48]  K. Flegal,et al.  Prevalence and trends in obesity among US adults, 1999-2000. , 2002, JAMA.

[49]  S. Ho,et al.  Is waist circumference a useful measure in predicting health outcomes in the elderly? , 2002, International Journal of Obesity.

[50]  B. Sternfeld,et al.  Associations of body composition with physical performance and self-reported functional limitation in elderly men and women. , 2002, American journal of epidemiology.

[51]  J. Oppert,et al.  Anthropometric estimates of muscle and fat mass in relation to cardiac and cancer mortality in men: the Paris Prospective Study. , 2002, The American journal of clinical nutrition.

[52]  G. Berglund,et al.  A prospective study of adiposity and all-cause mortality: the Malmö Diet and Cancer Study. , 2002, Obesity research.

[53]  Robert Ross,et al.  Low Relative Skeletal Muscle Mass (Sarcopenia) in Older Persons Is Associated with Functional Impairment and Physical Disability , 2002, Journal of the American Geriatrics Society.

[54]  P. Barberger‐Gateau,et al.  Nutritional status of healthy elderly persons living in Dordogne, France, and relation with mortality and cognitive or functional decline , 2002, European Journal of Clinical Nutrition.

[55]  A. Tremblay,et al.  Weight loss-induced rise in plasma pollutant is associated with reduced skeletal muscle oxidative capacity. , 2002, American journal of physiology. Endocrinology and metabolism.

[56]  A. Matsumoto.  Andropause: clinical implications of the decline in serum testosterone levels with aging in men. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[57]  B. Penninx,et al.  Obese, older adults with knee osteoarthritis: weight loss, exercise, and quality of life. , 2002, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[58]  Truls Østbye,et al.  The Effect of Middle‐ and Old‐Age Body Mass Index on Short‐Term Mortality in Older People , 2001, Journal of the American Geriatrics Society.

[59]  L. Fried,et al.  Weight Change in Old Age and its Association with Mortality , 2001, Journal of the American Geriatrics Society.

[60]  G. Fonarow,et al.  The relationship between obesity and mortality in patients with heart failure. , 2001, Journal of the American College of Cardiology.

[61]  D. Grabowski,et al.  High Body Mass Index Does Not Predict Mortality in Older People: Analysis of the Longitudinal Study of Aging , 2001, Journal of the American Geriatrics Society.

[62]  E. Rothenberg,et al.  Body mass index, weight change and mortality in the elderly. A 15 y longitudinal population study of 70 y olds , 2001, European Journal of Clinical Nutrition.

[63]  H. Krumholz,et al.  An evidence-based assessment of federal guidelines for overweight and obesity as they apply to elderly persons. , 2001, Archives of internal medicine.

[64]  M. Rosenberg,et al.  Canada's elderly population: the challenges of diversity , 2001 .

[65]  I. Vuori,et al.  Body mass index, physical inactivity and low level of physical fitness as determinants of all-cause and cardiovascular disease mortality—16 y follow-up of middle-aged and elderly men and women , 2000, International Journal of Obesity.

[66]  G. Onder,et al.  Body mass index and mortality among hospitalized patients. , 2000, Archives of internal medicine.

[67]  E. Rimm,et al.  Adiposity and mortality in men. , 2000, American journal of epidemiology.

[68]  E. Fracassi,et al.  Waist circumference and abdominal sagittal diameter as surrogates of body fat distribution in the elderly: their relation with cardiovascular risk factors , 2000, International Journal of Obesity.

[69]  T. Sellers,et al.  Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study. , 2000, Archives of internal medicine.

[70]  W. Applegate,et al.  Effect of Voluntary Weight Loss on Bone Mineral Density in Older Overweight Women , 2000, Journal of the American Geriatrics Society.

[71]  M. Elia,et al.  Total energy expenditure in the elderly , 2000, European journal of clinical nutrition.

[72]  M. Visser,et al.  Waist Circumference and Sagittal Diameter Reflect Total Body Fat Better Than Visceral Fat in Older Men and Women: The Health, Aging and Body Composition Study , 2000, Annals of the New York Academy of Sciences.

[73]  B. Davis,et al.  Relation of low body mass to death and stroke in the systolic hypertension in the elderly program. The SHEP Cooperative Research Group. , 2000, Archives of internal medicine.

[74]  G. Bray,et al.  The epidemic of obesity. , 2000, The Western journal of medicine.

[75]  T. Parker,et al.  Quality of life and stimulation of weight gain after treatment with megestrol acetate: correlation between cytokine levels and nutritional status, appetite in geriatric patients with wasting syndrome. , 2000, The journal of nutrition, health & aging.

[76]  B. Heitmann,et al.  Mortality associated with body fat, fat-free mass and body mass index among 60-year-old Swedish men—a 22-year follow-up. The study of men born in 1913 , 2000, International Journal of Obesity.

[77]  J. Sorkin,et al.  Longitudinal change in height of men and women: implications for interpretation of the body mass index: the Baltimore Longitudinal Study of Aging. , 1999, American journal of epidemiology.

[78]  G. Colditz,et al.  The disease burden associated with overweight and obesity. , 1999, JAMA.

[79]  M. Thun,et al.  Body-mass index and mortality in a prospective cohort of U.S. adults. , 1999, The New England journal of medicine.

[80]  K. Jöckel,et al.  Effect of age on excess mortality in obesity. , 1999, JAMA.

[81]  K. Yano,et al.  The association of body weight and anthropometry with mortality in elderly men: The Honolulu Heart Program , 1999, International Journal of Obesity.

[82]  S. Yusuf.  The global problem of cardiovascular disease. , 1998, International journal of clinical practice. Supplement.

[83]  P. Whelton,et al.  Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group. , 1998, JAMA.

[84]  K. Nair,et al.  Disruption of the relationship between fat content and leptin levels with aging in humans. , 1998, The Journal of clinical endocrinology and metabolism.

[85]  K Clark,et al.  The effect of age on the association between body-mass index and mortality. , 1998, Journal of insurance medicine.

[86]  Claude Bouchard,et al.  Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: Executive summary , 1998 .

[87]  D. Hans,et al.  How Hip and Whole-Body Bone Mineral Density Predict Hip Fracture in Elderly Women: The EPIDOS Prospective Study , 1998, Osteoporosis International.

[88]  R. Micciolo,et al.  Effects of age on body fat distribution and cardiovascular risk factors in women. , 1997, The American journal of clinical nutrition.

[89]  M. Heo,et al.  Body mass index and all-cause mortality among people age 70 and over: the Longitudinal Study of Aging , 1997, International Journal of Obesity.

[90]  C. Fabrigoule,et al.  Disability and cognitive impairment in the elderly. , 1997, Disability and rehabilitation.

[91]  A. Nissinen,et al.  Short-term all-cause mortality and its determinants in elderly male populations in Finland, The Netherlands, and Italy: the FINE Study. Finland, Italy, Netherlands Elderly Study. , 1996, Preventive medicine.

[92]  G. Beall,et al.  Dietary intake and counseling, weight maintenance, and the course of HIV infection. , 1995, Journal of the American Dietetic Association.

[93]  N. Cook,et al.  Does weight loss from middle age to old age explain the inverse weight mortality relation in old age? , 1995, American journal of epidemiology.

[94]  L. DiPietro.  Physical Activity, Body Weight, and Adiposity: An Epidemiologic Perspective , 1995, Exercise and sport sciences reviews.

[95]  S. Heymsfield,et al.  Human body composition and the epidemiology of chronic disease. , 1995, Obesity research.

[96]  S. Cummings,et al.  Correlates of impaired function in older women. , 1995, Journal of the American Geriatrics Society.

[97]  J J Anderson,et al.  Effects of weight and body mass index on bone mineral density in men and women: The framingham study , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[98]  A. Coulston,et al.  Prevalence of malnutrition in the elderly admitted to long-term-care facilities. , 1993, Journal of the American Dietetic Association.

[99]  M. Blackman,et al.  Human growth hormone and human aging. , 1993, Endocrine reviews.

[100]  R. DeFronzo,et al.  Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease , 1991, Diabetes Care.

[101]  E. Kinney,et al.  Relationship Between Body Weight and Mortality in Men Aged 75 Years and Older , 1990, Southern medical journal.

[102]  D. Drinkwater,et al.  Continuing diet trends in men: the Baltimore Longitudinal Study of Aging (1961-1987). , 1990, Journal of gerontology.

[103]  P. Björntorp.  "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. , 1990, Arteriosclerosis.

[104]  J. Albu,et al.  Body composition, not body weight, is related to cardiovascular disease risk factors and sex hormone levels in men. , 1987, The Journal of clinical investigation.

[105]  J. Tobin,et al.  Impact of age on weight goals. , 1985, Annals of internal medicine.