Kinetics and mechanics of cell adhesion.

Cell adhesion is mediated by specific interaction between receptors and ligands. Such interaction provides not only physical linkage but also communication between the cell and its environment. The kinetics and mechanics of cell adhesion are coupled, because force can influence the formation and dissociation of receptor-ligand bonds. The kinetic rates and their force dependence determine how likely, how rapidly and how strongly cells bind as well as how long they remain bound. Since adhesion molecules are linked to apposing cellular membranes, their interaction is governed by two-dimensional (2D) kinetics. This is in contrast to the three-dimensional (3D) binding of soluble ligands to cell surface receptors. Unlike the 3D case in which many methods are available for measuring kinetic rates, not until recently have the 2D kinetic rates become experimentally measurable. In this review, I will discuss the recent progress in the experimental methods that enable quantification of the relevant kinetic and mechanical parameters, the fundamental concepts that underlie the physics of the biological phenomena, and the mathematical models that relate functions to the intrinsic properties of the adhesion molecules.

[1]  C. Zhu,et al.  Measuring two-dimensional receptor-ligand binding kinetics by micropipette. , 1998, Biophysical journal.

[2]  H. Gaub,et al.  Intermolecular forces and energies between ligands and receptors. , 1994, Science.

[3]  C. Zhu,et al.  Analysis of competition binding between soluble and membrane-bound ligands for cell surface receptors. , 1999, Biophysical journal.

[4]  T. Springer,et al.  Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[5]  D. Lauffenburger,et al.  A dynamical model for receptor-mediated cell adhesion to surfaces. , 1987, Biophysical journal.

[6]  E. Evans,et al.  Chapter 15 - Physical Actions in Biological Adhesion , 1995 .

[7]  D. Torney,et al.  The reaction-limited kinetics of membrane-to-surface adhesion and detachment , 1988, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[8]  S Kaplanski,et al.  Granulocyte-endothelium initial adhesion. Analysis of transient binding events mediated by E-selectin in a laminar shear flow. , 1993, Biophysical journal.

[9]  D. Anselmetti,et al.  Binding strength between cell adhesion proteoglycans measured by atomic force microscopy , 1995, Science.

[10]  S Chien,et al.  Mechanics of Rouleau formation. , 1981, Biophysical journal.

[11]  H. Goldsmith,et al.  Kinetics and locus of failure of receptor-ligand-mediated adhesion between latex spheres. I. Protein-carbohydrate bond. , 1996, Biophysical journal.

[12]  G. I. Bell.  Models for the specific adhesion of cells to cells. , 1978, Science.

[13]  D. Hammer,et al.  Kinetics of adhesion of IgE-sensitized rat basophilic leukemia cells to surface-immobilized antigen in Couette flow. , 1998, Biophysical journal.

[14]  Pierre Bongrand,et al.  Physics of cell adhesion , 1982 .

[15]  Donald A. McQuarrie,et al.  Kinetics of Small Systems. I , 1963 .

[16]  J. Thiery,et al.  Experimental study of the interaction range and association rate of surface-attached cadherin 11. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[17]  H. Goldsmith,et al.  Interaction forces between red cells agglutinated by antibody. I. Theoretical. , 1986, Biophysical journal.

[18]  M Long,et al.  Probabilistic modeling of shear-induced formation and breakage of doublets cross-linked by receptor-ligand bonds. , 1999, Biophysical journal.

[19]  D. Hammer,et al.  Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow , 1995, Nature.

[20]  P Bongrand,et al.  Measuring the Lifetime of Bonds Made between Surface-linked Molecules (*) , 1995, The Journal of Biological Chemistry.

[21]  O. Coenen,et al.  Interaction forces between red cells agglutinated by antibody. IV. Time and force dependence of break-up. , 1993, Biophysical journal.

[22]  D E Leckband,et al.  Direct force measurements of specific and nonspecific protein interactions. , 1994, Biochemistry.

[23]  H. Gaub,et al.  Adhesion forces between individual ligand-receptor pairs. , 1994, Science.

[24]  Michael Loran Dustin,et al.  Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area , 1996, The Journal of cell biology.

[25]  C. Zhu,et al.  Determining force dependence of two-dimensional receptor-ligand binding affinity by centrifugation. , 1998, Biophysical journal.

[26]  P. Bongrand,et al.  Experimental Study of the Rate of Bond Formation Betwwen Individual Receptor-Coated Spheres and Ligand-Bearing Surfaces , 1996 .

[27]  D. Hammer,et al.  Simulation of cell rolling and adhesion on surfaces in shear flow: general results and analysis of selectin-mediated neutrophil adhesion. , 1992 .

[28]  H Schindler,et al.  Detection and localization of individual antibody-antigen recognition events by atomic force microscopy. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[29]  P Bongrand,et al.  Cell adhesion. Competition between nonspecific repulsion and specific bonding. , 1984, Biophysical journal.

[30]  Timothy A. Springer,et al.  An Automatic Braking System That Stabilizes Leukocyte Rolling by an Increase in Selectin Bond Number with Shear , 1999, The Journal of cell biology.

[31]  E. Evans,et al.  Dynamic strength of molecular adhesion bonds. , 1997, Biophysical journal.

[32]  R. Skalak,et al.  A stochastic model of leukocyte rolling. , 1995, Biophysical journal.

[33]  E. Evans.  Detailed mechanics of membrane-membrane adhesion and separation. I. Continuum of molecular cross-bridges. , 1985, Biophysical journal.

[34]  Timothy A. Springer,et al.  The Kinetics of L-selectin Tethers and the Mechanics of Selectin-mediated Rolling , 1997, The Journal of cell biology.

[35]  D A Lauffenburger,et al.  Receptor-mediated cell attachment and detachment kinetics. I. Probabilistic model and analysis. , 1990, Biophysical journal.

[36]  A Leung,et al.  Detachment of agglutinin-bonded red blood cells. I. Forces to rupture molecular-point attachments. , 1991, Biophysical journal.

[37]  R. Merkel,et al.  Energy landscapes of receptor–ligand bonds explored with dynamic force spectroscopy , 1999, Nature.

[38]  P. Bongrand,et al.  The dependence of the association rate of surface‐attached adhesion molecules CD2 and CD48 on separation distance , 1997, FEBS Letters.

[39]  D. Hammer,et al.  The forward rate of binding of surface-tethered reactants: effect of relative motion between two surfaces. , 1999, Biophysical journal.

[40]  M. Hegner,et al.  Specific antigen/antibody interactions measured by force microscopy. , 1996, Biophysical journal.

[41]  P. Selvaraj,et al.  The Membrane Anchor Influences Ligand Binding Two-dimensional Kinetic Rates and Three-dimensional Affinity of FcγRIII (CD16)* , 2000, The Journal of Biological Chemistry.

[42]  Michael Loran Dustin,et al.  Adhesive Bond Dynamics in Contacts between T Lymphocytes and Glass-supported Planar Bilayers Reconstituted with the Immunoglobulin-related Adhesion Molecule CD58* , 1997, The Journal of Biological Chemistry.

[43]  Michael Loran Dustin,et al.  Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity* , 1997, The Journal of Biological Chemistry.