It has been reported that wrong medicine box has been delivered to patient accidentally at hospital's Inpatient Department, so the patient may take the wrong medicine and the medical incident occurs consequently. In order to resolving this problem, it is necessary to design intelligent medicine box monitoring and management system. This system integrates technologies involving network, RFID, and touch screen. At the network, the system monitors and controls the releasing process of medicine box through RFID label ring, and displays the medicine's name, dosing time, notes and other relevant information for patients on the touch screen. Therefore the patient would be reminded to take the medicine clearly and regularly. The system could effectively resolve the problem of negligence and misoperation when medicine distribution, and as well avoid the accidental medicine taking for patient.