Novel CuS-based nanoprobes for photoacoustic molecular imaging in the second near-infrared region

In this work, protein-modified hydrophilic copper sufide (CuS) nanotriangles with tunable absorption in the second near-infrared (NIR-II) region are developed, which can be served as contrast agents for enhanced in vivo photoacoustic imaging. In vitro and in vivo toxicity analysis are also performed, which show that the nanoprobes are biocompatible for most of the test cases. As a result, the nanoprones is able to pave a new avenue for improving the photoacoustic imaigng contrast and penetration depth in cancer detection. It should be pointed out that other functional blocks may also be linked on it, which makes it a general method to design multifunctional nanoprobes.

[1]  Jiaguo Yu,et al.  Ion-Exchange Synthesis and Enhanced Visible-Light Photoactivity of CuS/ZnS Nanocomposite Hollow Spheres , 2010 .

[2]  M. C. Mancini,et al.  Bioimaging: second window for in vivo imaging. , 2009, Nature nanotechnology.

[3]  Yang Shu,et al.  Protein-modified hollow copper sulfide nanoparticles carrying indocyanine green for photothermal and photodynamic therapy. , 2016, Journal of materials chemistry. B.

[4]  Yan Xing,et al.  Radiolabeled Nanoparticles for Multimodality Tumor Imaging , 2014, Theranostics.

[5]  Fei He,et al.  Doxorubicin-conjugated CuS nanoparticles for efficient synergistic therapy triggered by near-infrared light. , 2016, Dalton transactions.

[6]  Zhimin Li,et al.  Protein-directed solution-phase green synthesis of BSA-conjugated M(x)Se(y) (M = Ag, Cd, Pb, Cu) nanomaterials. , 2011, Chemistry, an Asian journal.

[7]  Younan Xia,et al.  Gold Nanocages: A Novel Class of Multifunctional Nanomaterials for Theranostic Applications , 2010, Advanced functional materials.

[8]  A. Tao,et al.  Shape Focusing During the Anisotropic Growth of CuS Triangular Nanoprisms , 2015 .

[9]  R. Schaller,et al.  Tuning the excitonic and plasmonic properties of copper chalcogenide nanocrystals. , 2012, Journal of the American Chemical Society.

[10]  Gang Bao,et al.  Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation , 2013, Theranostics.

[11]  Daxiong Wu,et al.  Fast synthesis, formation mechanism, and control of shell thickness of CuS hollow spheres. , 2009, Inorganic chemistry.

[12]  Wei Huang,et al.  Transferring Biomarker into Molecular Probe: Melanin Nanoparticle as a Naturally Active Platform for Multimodality Imaging , 2014, Journal of the American Chemical Society.

[13]  J. Pearlman,et al.  Medical imaging techniques in the evaluation of strategies for therapeutic angiogenesis. , 2002, Current pharmaceutical design.

[14]  Xiaobo Wang,et al.  Size Control of Monodisperse Copper Sulfide Faceted Nanocrystals and Triangular Nanoplates , 2007 .

[15]  J. Mintorovitch,et al.  Comparison of Magnetic Properties of MRI Contrast Media Solutions at Different Magnetic Field Strengths , 2005, Investigative radiology.

[16]  Mauro Ferrari,et al.  Hierarchically Structured Magnetic Nanoconstructs with Enhanced Relaxivity and Cooperative Tumor Accumulation , 2014, Advanced functional materials.

[17]  Dong Liang,et al.  CuS Nanodots with Ultrahigh Efficient Renal Clearance for Positron Emission Tomography Imaging and Image-Guided Photothermal Therapy. , 2015, ACS nano.

[18]  H. Lee,et al.  CuS/CdS Quantum Dot Composite Sensitizer and Its Applications to Various TiO2 Mesoporous Film-Based Solar Cell Devices. , 2015, Langmuir : the ACS journal of surfaces and colloids.

[19]  Jun Liu,et al.  Rapid and scalable route to CuS biosensors: a microwave-assisted Cu-complex transformation into CuS nanotubes for ultrasensitive nonenzymatic glucose sensor , 2011 .

[20]  Hao Hong,et al.  In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine , 2015, ACS nano.

[21]  D. Altamura,et al.  Metallic-like stoichiometric copper sulfide nanocrystals: phase- and shape-selective synthesis, near-infrared surface plasmon resonance properties, and their modeling. , 2013, ACS nano.

[22]  Wei Lu,et al.  Tumor Site–Specific Silencing ofNF-κB p65by Targeted Hollow Gold Nanosphere–Mediated Photothermal Transfection , 2010, Cancer Research.

[23]  S. Emelianov,et al.  Photoacoustic imaging in cancer detection, diagnosis, and treatment guidance. , 2011, Trends in biotechnology.

[24]  Huabei Jiang,et al.  Two schemes for quantitative photoacoustic tomography based on Monte Carlo simulation. , 2016, Medical physics.