Dynamic Aspects of Neuronal Cooperativity: Fast Stimulus-Locked Modulations of Effective Connectivity

Cooperativity among neurons is usually measured by cross-correlation of their simultaneously recorded firing activities under some appropriate stimulus condition. The ordinary ‘raw’ correlogram presents a time averaged count of (near) coincident spikes, and in general contains contributions from different origins: stimulus-induced modulations of single neuron firing rates and various types of (possibly nonstationary) interaction between the neurons. Appropriate normalization procedures are therefore essential in order to compare results from different experiments; only after such normalization may we interpret residual correlation as indicative of (possibly stimulus dependent) ‘effective connectivity’ among the neurons.

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