Simulation of blood volume change during hemodialysis

In this project a computer simulation for hemodialysis was implemented. One objective of the project was to create a graphical user interface for the computer model that facilitates specification of the dialysis session to be simulated. A top-down stepwise refinement approach was used to develop the simulator. The simulator can be used as an educational tool for understanding hemodialysis and will allow physicians to develop strategies for varying the ultrafiltration rate with the goal of achieving an acceptable blood volume profile.

[1]  J. C. James,et al.  Parameter estimation for a model of blood volume change during hemodialysis , 1992, Proceedings IEEE Southeastcon '92.

[2]  K. Maeda,et al.  Newly developed circulating blood volume-monitoring system and its clinical application for measuring changes in blood volume during hemofiltration. , 1986, Artificial organs.

[3]  C. Colton,et al.  Transcellular urea gradients cause minimal depletion of extracellular volume during hemodialysis. , 1989, ASAIO transactions.

[4]  T. Kenner,et al.  Nature and rate of vascular refilling during hemodialysis and ultrafiltration. , 1992, Kidney international.

[5]  H Mann,et al.  Kinetic modelling and continuous on-line blood volume measurement during dialysis therapy. , 1990, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[6]  A. Guyton,et al.  Interstitial Fluid Pressure: II. Pressure‐Volume Curves of Interstitial Space , 1965, Circulation research.

[7]  J T Daugirdas,et al.  A regional blood circulation alternative to in-series two compartment urea kinetic modeling. , 1993, ASAIO journal.

[8]  E Sarti,et al.  A Digital Computer Model for Optimal Programming of Hemodialytic Treatment , 1988, The International journal of artificial organs.

[9]  G Kimura,et al.  Model prediction of plasma volume change induced by hemodialysis. , 1984, The Journal of laboratory and clinical medicine.

[10]  J. V. van Stone,et al.  Prediction of postdialysis serum sodium concentration and transcellular fluid shift without measuring body fluid volumes. , 1983, Artificial organs.