Bronchoalveolar cytology for diagnosing pulmonary GVHD after bone marrow transplant in children

Cytological composition of bronchoalveolar lavage (BAL) fluid in pediatric bone marrow transplant (BMT) recipients with pulmonary complications has not been comprehensively described and BAL specific markers of pulmonary GVHD are lacking. The aim of this retrospective study was to assess the role of BAL in the diagnosis of pulmonary GVHD by comparing BAL cytological findings between pediatric allogenic BMT patients with pulmonary complications and oncology children receiving chemotherapy alone.

[1]  J. Collaco,et al.  Pulmonary dysfunction in pediatric hematopoietic stem cell transplant patients: Non‐infectious and long‐term complications , 2007, Pediatric blood & cancer.

[2]  H. Deeg,et al.  The clinical spectrum of acute graft-versus-host disease. , 2006, Seminars in hematology.

[3]  D. Cornfield,et al.  Natural history of pulmonary complications in children after bone marrow transplantation. , 2005, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[4]  S. Crawford,et al.  Pulmonary complications of solid organ and hematopoietic stem cell transplantation. , 2004, American journal of respiratory and critical care medicine.

[5]  S. Pambuccian,et al.  Atypical cells in bronchoalveolar lavage specimens from bone marrow transplant recipients. A potential pitfall. , 2003, American journal of clinical pathology.

[6]  A. Clément,et al.  Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society. , 2000 .

[7]  N. P. Ohori.  Epithelial cell atypia in bronchoalveolar lavage specimens from lung transplant recipients. , 1999, American journal of clinical pathology.

[8]  F. Ratjen,et al.  Differential cytology of bronchoalveolar lavage fluid in immunosuppressed children with pulmonary infiltrates. , 1996, Archives of disease in childhood.

[9]  P. Hassoun,et al.  Pulmonary complications of bone marrow transplantation. , 1996, Chest.

[10]  S. Yousem.  The histological spectrum of pulmonary graft-versus-host disease in bone marrow transplant recipients. , 1995, Human pathology.

[11]  E D Thomas,et al.  1994 Consensus Conference on Acute GVHD Grading. , 1995, Bone marrow transplantation.

[12]  M. Brendel,et al.  Differential cytology of bronchoalveolar lavage fluid in normal children. , 1994, The European respiratory journal.

[13]  T. Similowski,et al.  Late CD8+ lymphocytic alveolitis after allogeneic bone marrow transplantation and chronic graft-versus-host disease. , 1994, American journal of respiratory and critical care medicine.

[14]  S. Crawford,et al.  MONONUCLEAR CELL RECONSTITUTION IN THE LUNG AFTER MARROW TRANSPLANTATION LACK OF INFLUENCE OF CYTOMEGALOVIRUS PNEUMONIA, IRRADIATION, AND GRAFT‐VERSUS-HOST DISEASE , 1993, Transplantation.

[15]  L. Volin,et al.  Use of bronchoalveolar lavage cytology and determination of protein contents in pulmonary complications of bone marrow transplant recipients. , 1990, Bone marrow transplantation.