Platelike WO3 sensitized with CdS quantum dots heterostructures for photoelectrochemical dynamic sensing of H2O2 based on enzymatic etching.

A platelike tungsten trioxide (WO3) sensitized with CdS quantum dots (QDs) heterojunction is developed for solar-driven, real-time, and selective photoelectrochemical (PEC) sensing of H2O2 in the living cells. The structure is synthesized by hydrothermally growing platelike WO3 on fluorine doped tin oxide (FTO) and subsequently sensitized with CdS QDs. The as-prepared WO3-CdS QDs heterojunction achieve significant photocurrent enhancement, which is remarkably beneficial for light absorption and charge carrier separation. Based on the enzymatic etching of CdS QDs enables the activation of quenching the charge transfer efficiency, thus leading to sensitive PEC recording of H2O2 level in buffer and cellular environments. The results indicated that the proposed method will pave the way for the development of excellent PEC sensing platform with the quantum dot sensitization. This study could also provide a new train of thought on designing of self-operating photoanode in PEC sensing, promoting the application of semiconductor nanomaterials in photoelectrochemistry.

[1]  Peng Wang,et al.  Cathode photoelectrochemical sensing of copper(II) based on analyte-induced formation of exciton trapping. , 2012, Chemical communications.

[2]  Enhancing photoelectrochemical performance with a bilayer-structured film consisting of graphene–WO3 nanocrystals and WO3 vertically plate-like arrays as photoanodes , 2014 .

[3]  Wenzheng Li,et al.  Ion-exchange route to Au-Cu(x)OS yolk-shell nanostructures with porous shells and their ultrasensitive H2O2 detection. , 2012, ACS applied materials & interfaces.

[4]  Yuming Dong,et al.  A novel photoelectrochemical sensor based on photocathode of PbS quantum dots utilizing catalase mimetics of bio-bar-coded platinum nanoparticles/G-quadruplex/hemin for signal amplification. , 2015, Biosensors & bioelectronics.

[5]  Jie Li,et al.  In situ synthesis of g-C3N4/WO3 heterojunction plates array films with enhanced photoelectrochemical performance , 2015 .

[6]  P. Schmuki,et al.  Nitrogen doping of nanoporous WO3 layers by NH3 treatment for increased visible light photoresponse , 2010, Nanotechnology.

[7]  C. Winterbourn,et al.  Reconciling the chemistry and biology of reactive oxygen species. , 2008, Nature chemical biology.

[8]  Jingying Li,et al.  Cell-Capture and Release Platform Based on Peptide-Aptamer-Modified Nanowires. , 2016, ACS applied materials & interfaces.

[9]  Arnan Mitchell,et al.  Nanostructured Tungsten Oxide – Properties, Synthesis, and Applications , 2011 .

[10]  I. Weissman,et al.  Stems Cells and the Pathways to Aging and Cancer , 2008, Cell.

[11]  Maurizio Quinto,et al.  An interference free amperometric biosensor for the detection of biogenic amines in food products. , 2007, Biosensors & bioelectronics.

[12]  F. Huo,et al.  Stable quantum dot photoelectrolysis cell for unassisted visible light solar water splitting. , 2014, ACS nano.

[13]  D. Raftery,et al.  Photoelectrochemical and structural characterization of carbon-doped WO3 films prepared via spray pyrolysis , 2009 .

[14]  Xiangfeng Duan,et al.  Progress, challenge and perspective of heterogeneous photocatalysts. , 2013, Chemical Society reviews.

[15]  Xuejin Li,et al.  Combined nanostructured Bi2S3/TNA photoanode and Pt/SiPVC photocathode for efficient self-biasing photoelectrochemical hydrogen and electricity generation , 2014 .

[16]  Guang-Li Wang,et al.  Selective detection of trace amount of Cu2+ using semiconductor nanoparticles in photoelectrochemical analysis. , 2010, Nanoscale.

[17]  Fang Qian,et al.  Double-sided CdS and CdSe quantum dot co-sensitized ZnO nanowire arrays for photoelectrochemical hydrogen generation. , 2010, Nano letters.

[18]  Xiaoru Zhang,et al.  Aptamer based photoelectrochemical cytosensor with layer-by-layer assembly of CdSe semiconductor nanoparticles as photoelectrochemically active species. , 2011, Biosensors & bioelectronics.

[19]  Qingming Shen,et al.  ZnO/CdS Hierarchical Nanospheres for Photoelectrochemical Sensing of Cu2+ , 2011 .

[20]  Thomas E Mallouk,et al.  Design and development of photoanodes for water-splitting dye-sensitized photoelectrochemical cells. , 2013, Chemical Society reviews.

[21]  Jinghua Yu,et al.  Paper-based electrochemiluminescence origami cyto-device for multiple cancer cells detection using porous AuPd alloy as catalytically promoted nanolabels. , 2015, Biosensors & bioelectronics.

[22]  Hui Jiang,et al.  Highly sensitive graphene-Pt nanocomposites amperometric biosensor and its application in living cell H2O2 detection. , 2014, Analytical chemistry.

[23]  Qi-yuan Chen,et al.  Preparation and water-splitting photocatalytic behavior of S-doped WO3 , 2012 .

[24]  Jinghua Yu,et al.  Aptamer-Based electrochemiluminescent detection of MCF-7 cancer cells based on carbon quantum dots coated mesoporous silica nanoparticles , 2014 .

[25]  M. Zeller,et al.  Photoelectrochemical and photoresponsive properties of Bi2S3 nanotube and nanoparticle thin films , 2010 .

[26]  Shaohua Shen,et al.  A perspective on solar-driven water splitting with all-oxide hetero-nanostructures , 2011 .

[27]  Jie Li,et al.  Hydrothermal synthesis and photoelectrochemical properties of vertically aligned tungsten trioxide (hydrate) plate-like arrays fabricated directly on FTO substrates , 2012 .

[28]  Jishan Li,et al.  AgNP-DNA@GQDs hybrid: new approach for sensitive detection of H2O2 and glucose via simultaneous AgNP etching and DNA cleavage. , 2014, Analytical chemistry.

[29]  Gengfeng Zheng,et al.  Mesoporous Fe2O3-CdS Heterostructures for Real-Time Photoelectrochemical Dynamic Probing of Cu(2+). , 2015, Analytical chemistry.

[30]  Yongping Luo,et al.  Detection of extracellular H2O2 released from human liver cancer cells based on TiO2 nanoneedles with enhanced electron transfer of cytochrome c. , 2009, Analytical chemistry.

[31]  Yaomin Li,et al.  CdS quantum dots sensitized platelike WO3 photoelectrodes with a TiO2 buffer-layer , 2014 .

[32]  Jinping Liu,et al.  Composition-Graded ZnxCd1–xSe@ZnO Core–Shell Nanowire Array Electrodes for Photoelectrochemical Hydrogen Generation , 2012 .

[33]  Wei-Wei Zhao,et al.  Photoelectrochemical bioanalysis: the state of the art. , 2015, Chemical Society reviews.

[34]  Jiye Shi,et al.  Unraveling the role of hydrogen peroxide in α-synuclein aggregation using an ultrasensitive nanoplasmonic probe. , 2015, Analytical chemistry.

[35]  Alexander J. Cowan,et al.  Long-lived charge separated states in nanostructured semiconductor photoelectrodes for the production of solar fuels. , 2013, Chemical Society reviews.

[36]  Yuh‐Lang Lee,et al.  CdS/CdSe Co-Sensitized TiO2 Photoelectrode for Efficient Hydrogen Generation in a Photoelectrochemical Cell† , 2010 .

[37]  P. Zambonin,et al.  Electrosynthesized poly(pyrrole)/poly(2-naphthol) bilayer membrane as an effective anti-interference layer for simultaneous determination of acethylcholine and choline by a dual electrode amperometric biosensor. , 2006, Biosensors & bioelectronics.

[38]  Serge Cosnier,et al.  Photoelectrochemical immunosensor for label-free detection and quantification of anti-cholera toxin antibody. , 2006, Journal of the American Chemical Society.

[39]  W. Muller,et al.  Scavenging of Extracellular H2O2 by Catalase Inhibits the Proliferation of HER-2/Neu-transformed Rat-1 Fibroblasts through the Induction of a Stress Response* , 2001, The Journal of Biological Chemistry.

[40]  T. Peng,et al.  Synthesis of floriated In2S3 decorated with TiO2 nanoparticles for efficient photocatalytic hydrogen production under visible light , 2011 .

[41]  D. Pang,et al.  MUC-1 aptamer-conjugated dye-doped silica nanoparticles for MCF-7 cells detection. , 2013, Biomaterials.

[42]  K. Yan,et al.  A photoelectrochemical biosensor for o-aminophenol based on assembling of CdSe and DNA on TiO2 film electrode. , 2014, Biosensors & bioelectronics.

[43]  Xiaoru Zhang,et al.  Photoelectrochemical biosensor for detection of adenosine triphosphate in the extracts of cancer cells. , 2010, Chemical communications.

[44]  Tomoki Akita,et al.  All-solid-state Z-scheme in CdS–Au–TiO2 three-component nanojunction system , 2006, Nature materials.

[45]  Zhao Yue,et al.  Quantum-dot-based photoelectrochemical sensors for chemical and biological detection. , 2013, ACS applied materials & interfaces.

[46]  Frank E. Osterloh,et al.  Inorganic nanostructures for photoelectrochemical and photocatalytic water splitting. , 2013, Chemical Society reviews.

[47]  Yuming Dong,et al.  Novel photoelectrochemical hydrogen peroxide sensor based on hemin sensitized nanoporous NiO based photocathode , 2015 .

[48]  Wei Chen,et al.  In situ growth of surfactant-free gold nanoparticles on nitrogen-doped graphene quantum dots for electrochemical detection of hydrogen peroxide in biological environments. , 2015, Analytical chemistry.

[49]  F. Prinz,et al.  Efficiency enhancement of solid-state PbS quantum dot-sensitized solar cells with Al2O3 barrier layer , 2013 .

[50]  Yang Song,et al.  Mesoporous Pt Nanotubes as a Novel Sensing Platform for Sensitive Detection of Intracellular Hydrogen Peroxide. , 2015, ACS applied materials & interfaces.

[51]  Yaomin Li,et al.  Highly Efficient Photoelectrochemical Hydrogen Generation Using Zn(x)Bi2S(3+x) Sensitized Platelike WO₃ Photoelectrodes. , 2015, ACS applied materials & interfaces.

[52]  Shuai Chen,et al.  In situ growth of silver nanoparticles on graphene quantum dots for ultrasensitive colorimetric detection of H₂O₂ and glucose. , 2014, Analytical chemistry.

[53]  H. Pettersson,et al.  Dye-sensitized solar cells. , 2010, Chemical Reviews.

[54]  Jing Bai,et al.  Titanium dioxide nanomaterials for sensor applications. , 2014, Chemical reviews.

[55]  Canjun Liu,et al.  Photoelectrochemical properties and photocatalytic activity of nitrogen-doped nanoporous WO3 photoelectrodes under visible light , 2012 .

[56]  Chi Zhang,et al.  A new approach to light up the application of semiconductor nanomaterials for photoelectrochemical biosensors: using self-operating photocathode as a highly selective enzyme sensor. , 2014, Biosensors & bioelectronics.

[57]  I. Willner,et al.  Nucleic acid/quantum dots (QDs) hybrid systems for optical and photoelectrochemical sensing. , 2013, ACS applied materials & interfaces.