Cytotoxic Sesquiterpenoids from the Stem Bark of Aglaia harmsiana (Meliaceae)

Three aromadendrane-type sesquiterpenoids, spathulenol ( 1 ), 4β,10α-dihydroxyaromadendrane ( 2 ), and 4α,10α-dihydroxyaromadendrane ( 3 ) were isolated from the stem bark of Aglaia harmsiana (Meliaceae). Compound 3 was isolated for the first time from Aglaia genus. The chemical structures of isolated compounds were elucidated by various spectroscopic methods, including one and two-dimensional NMR, as well as mass spectroscopy analysis. These sesquiterpenoids 1 - 3 were evaluated for their cytotoxic activity against MCF-7 breast cancer cell lines. The IC 50 value of compound 1 - 3 were 31.65 ± 0.1, 8.41 ± 0.04 and 2.80 ± 0.02 µM, respectively. Among the aromadendrane-type sesquiterpenoids, compounds 2 and 3 , which do not have a double bond, showed higher activity than compound 1 . Whereas, compound 3 showed the strongest activity indicate that α configuration of hydroxyl group increases the cytotoxic activity.

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