Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity.
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[1] C. Anthony Hunt,et al. Identifying the Rules of Engagement Enabling Leukocyte Rolling, Activation, and Adhesion , 2010, PLoS Comput. Biol..
[2] Tai Ning Lam,et al. Mechanistic Insight from In Silico Pharmacokinetic Experiments: Roles of P-glycoprotein, Cyp3A4 Enzymes, and Microenvironments , 2010, Journal of Pharmacology and Experimental Therapeutics.
[3] Sean H. J. Kim,et al. At the Biological Modeling and Simulation Frontier , 2009, Pharmaceutical Research.
[4] G. An,et al. Agent‐based models in translational systems biology , 2009, Wiley interdisciplinary reviews. Systems biology and medicine.
[5] Sunwoo Park,et al. Evaluating an hepatic enzyme induction mechanism through coarse- and fine-grained measurements of an in silico liver , 2009, Complex..
[6] O. Sansom,et al. Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. , 2009, Gastroenterology.
[7] P. Georgopoulos,et al. Tissue‐Level Modeling of Xenobiotic Metabolism in Liver: An Emerging Tool for Enabling Clinical Translational Research , 2009, Clinical and translational science.
[8] A. Braeuning. Regulation of cytochrome P450 expression by Ras- and beta-catenin-dependent signaling. , 2009, Current drug metabolism.
[9] C. Hunt,et al. Discovering Plausible Mechanistic Details of Hepatic Drug Interactions , 2009, Drug Metabolism and Disposition.
[10] Sunwoo Park,et al. Computational Strategies Unravel and Trace How Liver Disease Changes Hepatic Drug Disposition , 2009, Journal of Pharmacology and Experimental Therapeutics.
[11] Glen E. P. Ropella,et al. Modeling and Simulation of Hepatic Drug Disposition Using a Physiologically Based, Multi-agent In Silico Liver , 2008, Pharmaceutical Research.
[12] Sunwoo Park,et al. Predictions of Hepatic Disposition Properties Using a Mechanistically Realistic, Physiologically Based Model , 2008, Drug Metabolism and Disposition.
[13] T. Henzinger,et al. Executable cell biology , 2007, Nature Biotechnology.
[14] C. Perret,et al. Voie Wnt/β-caténine et zonation métabolique du foie : un nouvel acteur pour un ancien concept , 2006 .
[15] Michael S. Roberts,et al. Physiologically Based Synthetic Models of Hepatic Disposition , 2006, Journal of Pharmacokinetics and Pharmacodynamics.
[16] S. Feng,et al. Liver‐specific loss of β‐catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice , 2006, Hepatology.
[17] Michael Schwarz,et al. Zonal gene expression in murine liver: Lessons from tumors , 2006, Hepatology.
[18] Uta Berger,et al. Pattern-Oriented Modeling of Agent-Based Complex Systems: Lessons from Ecology , 2005, Science.
[19] Melvin E Andersen,et al. Single cell analysis of switch-like induction of CYP1A1 in liver cell lines. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.
[20] Lindley Darden,et al. Strategies for Discovering Mechanisms: Schema Instantiation, Modular Subassembly, Forward/Backward Chaining , 2002, Philosophy of Science.
[21] M. Andersen,et al. Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.
[22] P. Matzinger. The Danger Model: A Renewed Sense of Self , 2002, Science.
[23] Y. Vodovotz,et al. Hepatocyte toll-like receptor 2 expression in vivo and in vitro: role of cytokines in induction of rat TLR2 gene expression by lipopolysaccharide. , 2000, Shock.
[24] K. Jungermann,et al. Oxygen: Modulator of metabolic zonation and disease of the liver , 2000, Hepatology.
[25] N J Walker,et al. Dose-dependent localization of TCDD in isolated centrilobular and periportal hepatocytes. , 1999, Toxicological sciences : an official journal of the Society of Toxicology.
[26] W H Lamers,et al. A mechanistic model for the development and maintenance of portocentral gradients in gene expression in the liver , 1999, Hepatology.
[27] M E Andersen,et al. Mechanistic modeling of rodent liver tumor promotion at low levels of exposure: an example related to dose-response relationships for 2,3,7,8-tetrachlorodibenzo-p-dioxin , 1998, Human & experimental toxicology.
[28] G. Lucier,et al. Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria. , 1998, Carcinogenesis.
[29] M E Andersen,et al. Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation. , 1997, Toxicology and applied pharmacology.
[30] K. Lindros. Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver. , 1997, General pharmacology.
[31] K. Jungermann,et al. Zonation of metabolism and gene expression in liver , 1995, Histochemistry and Cell Biology.
[32] K. Husgafvel‐Pursiainen,et al. Pretranslational induction of cytochrome P4501A enzymes by beta-naphthoflavone and 3-methylcholanthrene occurs in different liver zones. , 1994, Biochemical pharmacology.
[33] C J Portier,et al. Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver. , 1992, Cancer research.
[34] P. Dayan,et al. Q-learning , 1992, Machine Learning.
[35] M. Ingelman-Sundberg,et al. Zonation of cytochrome P450 isozyme expression and induction in rat liver. , 1992, European journal of biochemistry.
[36] C. Anthony Hunt,et al. Understanding the Role of Liver Zonation in Toxin Elimination , 2009 .
[37] Masaru Tomita,et al. Construction of a Biological Tissue Model Based on a Single-Cell Model: A Computer Simulation of Metabolic Heterogeneity in the Liver Lobule , 2008, Artificial Life.
[38] A. Capitano,et al. Induction of Zone‐Like Liver Function Gradients in HepG2 Cells by Varying Culture Medium Height , 2007, Biotechnology progress.
[39] K. Lindros,et al. Zonation of hepatic cytochrome P-450 expression and regulation. , 1998, The Biochemical journal.
[40] R. Gebhardt. Metabolic zonation of the liver: regulation and implications for liver function. , 1992, Pharmacology & therapeutics.
[41] Y. Masuda,et al. Histological evidence for dissociation of lipid peroxidation and cell necrosis in bromotrichloromethane hepatotoxicity in the perfused rat liver. , 1991, Japanese journal of pharmacology.