Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity.

[1]  C. Anthony Hunt,et al.  Identifying the Rules of Engagement Enabling Leukocyte Rolling, Activation, and Adhesion , 2010, PLoS Comput. Biol..

[2]  Tai Ning Lam,et al.  Mechanistic Insight from In Silico Pharmacokinetic Experiments: Roles of P-glycoprotein, Cyp3A4 Enzymes, and Microenvironments , 2010, Journal of Pharmacology and Experimental Therapeutics.

[3]  Sean H. J. Kim,et al.  At the Biological Modeling and Simulation Frontier , 2009, Pharmaceutical Research.

[4]  G. An,et al.  Agent‐based models in translational systems biology , 2009, Wiley interdisciplinary reviews. Systems biology and medicine.

[5]  Sunwoo Park,et al.  Evaluating an hepatic enzyme induction mechanism through coarse- and fine-grained measurements of an in silico liver , 2009, Complex..

[6]  O. Sansom,et al.  Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. , 2009, Gastroenterology.

[7]  P. Georgopoulos,et al.  Tissue‐Level Modeling of Xenobiotic Metabolism in Liver: An Emerging Tool for Enabling Clinical Translational Research , 2009, Clinical and translational science.

[8]  A. Braeuning.  Regulation of cytochrome P450 expression by Ras- and beta-catenin-dependent signaling. , 2009, Current drug metabolism.

[9]  C. Hunt,et al.  Discovering Plausible Mechanistic Details of Hepatic Drug Interactions , 2009, Drug Metabolism and Disposition.

[10]  Sunwoo Park,et al.  Computational Strategies Unravel and Trace How Liver Disease Changes Hepatic Drug Disposition , 2009, Journal of Pharmacology and Experimental Therapeutics.

[11]  Glen E. P. Ropella,et al.  Modeling and Simulation of Hepatic Drug Disposition Using a Physiologically Based, Multi-agent In Silico Liver , 2008, Pharmaceutical Research.

[12]  Sunwoo Park,et al.  Predictions of Hepatic Disposition Properties Using a Mechanistically Realistic, Physiologically Based Model , 2008, Drug Metabolism and Disposition.

[13]  T. Henzinger,et al.  Executable cell biology , 2007, Nature Biotechnology.

[14]  C. Perret,et al.  Voie Wnt/β-caténine et zonation métabolique du foie : un nouvel acteur pour un ancien concept , 2006 .

[15]  Michael S. Roberts,et al.  Physiologically Based Synthetic Models of Hepatic Disposition , 2006, Journal of Pharmacokinetics and Pharmacodynamics.

[16]  S. Feng,et al.  Liver‐specific loss of β‐catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice , 2006, Hepatology.

[17]  Michael Schwarz,et al.  Zonal gene expression in murine liver: Lessons from tumors , 2006, Hepatology.

[18]  Uta Berger,et al.  Pattern-Oriented Modeling of Agent-Based Complex Systems: Lessons from Ecology , 2005, Science.

[19]  Melvin E Andersen,et al.  Single cell analysis of switch-like induction of CYP1A1 in liver cell lines. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[20]  Lindley Darden,et al.  Strategies for Discovering Mechanisms: Schema Instantiation, Modular Subassembly, Forward/Backward Chaining , 2002, Philosophy of Science.

[21]  M. Andersen,et al.  Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[22]  P. Matzinger.  The Danger Model: A Renewed Sense of Self , 2002, Science.

[23]  Y. Vodovotz,et al.  Hepatocyte toll-like receptor 2 expression in vivo and in vitro: role of cytokines in induction of rat TLR2 gene expression by lipopolysaccharide. , 2000, Shock.

[24]  K. Jungermann,et al.  Oxygen: Modulator of metabolic zonation and disease of the liver , 2000, Hepatology.

[25]  N J Walker,et al.  Dose-dependent localization of TCDD in isolated centrilobular and periportal hepatocytes. , 1999, Toxicological sciences : an official journal of the Society of Toxicology.

[26]  W H Lamers,et al.  A mechanistic model for the development and maintenance of portocentral gradients in gene expression in the liver , 1999, Hepatology.

[27]  M E Andersen,et al.  Mechanistic modeling of rodent liver tumor promotion at low levels of exposure: an example related to dose-response relationships for 2,3,7,8-tetrachlorodibenzo-p-dioxin , 1998, Human & experimental toxicology.

[28]  G. Lucier,et al.  Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria. , 1998, Carcinogenesis.

[29]  M E Andersen,et al.  Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation. , 1997, Toxicology and applied pharmacology.

[30]  K. Lindros.  Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver. , 1997, General pharmacology.

[31]  K. Jungermann,et al.  Zonation of metabolism and gene expression in liver , 1995, Histochemistry and Cell Biology.

[32]  K. Husgafvel‐Pursiainen,et al.  Pretranslational induction of cytochrome P4501A enzymes by beta-naphthoflavone and 3-methylcholanthrene occurs in different liver zones. , 1994, Biochemical pharmacology.

[33]  C J Portier,et al.  Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver. , 1992, Cancer research.

[34]  P. Dayan,et al.  Q-learning , 1992, Machine Learning.

[35]  M. Ingelman-Sundberg,et al.  Zonation of cytochrome P450 isozyme expression and induction in rat liver. , 1992, European journal of biochemistry.

[36]  C. Anthony Hunt,et al.  Understanding the Role of Liver Zonation in Toxin Elimination , 2009 .

[37]  Masaru Tomita,et al.  Construction of a Biological Tissue Model Based on a Single-Cell Model: A Computer Simulation of Metabolic Heterogeneity in the Liver Lobule , 2008, Artificial Life.

[38]  A. Capitano,et al.  Induction of Zone‐Like Liver Function Gradients in HepG2 Cells by Varying Culture Medium Height , 2007, Biotechnology progress.

[39]  K. Lindros,et al.  Zonation of hepatic cytochrome P-450 expression and regulation. , 1998, The Biochemical journal.

[40]  R. Gebhardt.  Metabolic zonation of the liver: regulation and implications for liver function. , 1992, Pharmacology & therapeutics.

[41]  Y. Masuda,et al.  Histological evidence for dissociation of lipid peroxidation and cell necrosis in bromotrichloromethane hepatotoxicity in the perfused rat liver. , 1991, Japanese journal of pharmacology.