Value of Fetoscopy in Prenatal Diagnosis 1

A technique of fetoscopy and fetoscopic blood sampling is described that makes maximum use of ultrasound scanning. A particle size analyser is also an integral part of the procedure. The results are based on 170 fetoscopies, 85 of which were performed for diagnostic reasons. The anterior placenta is rarely a cause of failure and in many instances makes fetal blood sampling easier. Pure fetal blood is obtainable from the umbilical cord insertion in 95% of cases sampled after 18 weeks' gestation. Fetal mortality may be as low as 3% and long-term adverse sequelae have not yet been discovered.

[1]  C. Rodeck,et al.  PLASMA ASSAY OF FETAL FACTORS VIIIC AND IX FOR PRENATAL DIAGNOSIS OF HÆMOPHILIA , 1979, The Lancet.

[2]  C. Rodeck,et al.  UMBILICAL-CORD INSERTION AS SOURCE OF PURE FETAL BLOOD FOR PRENATAL DIAGNOSIS , 1979, The Lancet.

[3]  P. Newburger,et al.  Prenatal diagnosis of chronic granulomatous disease. , 1979, The New England journal of medicine.

[4]  C. Epstein,et al.  Prenatal genetic diagnosis in 3000 amniocenteses. , 1979, The New England journal of medicine.

[5]  C. Rodeck,et al.  Prenatal diagnosis of a galactosaemia heterozygote by fetal blood enzyme assay. , 1979, British medical journal.

[6]  C. Rodeck,et al.  Sampling pure fetal blood by fetoscopy in second trimester of pregnancy. , 1978, British medical journal.

[7]  W. Fuhrmann,et al.  [Fetoscopy (author's transl)]. , 1978, Zeitschrift fur Geburtshilfe und Perinatologie.

[8]  C. Rodeck,et al.  EARLY PRENATAL DIAGNOSIS OF NEURAL-TUBE DEFECTS BY ULTRASOUND-GUIDED FETOSCOPY , 1978, The Lancet.

[9]  J. Clegg,et al.  Antenatal diagnosis of thalassaemia major. , 1978, British medical journal.

[10]  Benzie Rj,et al.  Fetoscopy and anterior placentas. , 1977 .

[11]  Y. Kan,et al.  PRENATAL DIAGNOSIS OF β-THALASSÆMIA AND SICKLE-CELL ANÆMIA Experience with 24 Cases , 1977, The Lancet.

[12]  R. Benzie,et al.  Prenatal diagnosis by fetoscopy with subsequent normal delivery: report of a case. , 1976, American journal of obstetrics and gynecology.

[13]  K. Laurence,et al.  Hirschsprung's disease associated with congenital heart malformation, broad big toes, and ulnar polydactyly in sibs: a case for fetoscopy. , 1975, Journal of medical genetics.

[14]  J. Hobbins,et al.  FETAL BLOOD DRAWING , 1975, The Lancet.

[15]  J. Hobbins,et al.  In utero diagnosis of hemoglobinopathies. Technic for obtaining fetal blood. , 1974, The New England journal of medicine.

[16]  J. Hobbins,et al.  New method of intrauterine evaluation by the combined use of fetoscopy and ultrasound. , 1974, American journal of obstetrics and gynecology.

[17]  H. A. Gardner,et al.  The antenatal diagnosis of genetic disease. , 1974, American journal of obstetrics and gynecology.

[18]  Y. Kan,et al.  Fetal blood-sampling in utero. , 1974, Lancet.

[19]  C. Valenti.  Antenatal detection of hemoglobinopathies. A preliminary report. , 1973, American journal of obstetrics and gynecology.

[20]  C. Valenti.  Endoamnioscopy and fetal biopsy: a new technique. , 1972, American journal of obstetrics and gynecology.