APNOEA ASSOCIATED WITH THE INTRATHECAL ADMINISTRATION OF MORPHINE IN OBSTETRICS

The intrathecal administration of hyperbaric morphine 1 mg for pain relief during labour was followed, 7 h after injection, and 1 h after delivery, by respiratory depression. Pulseoximetry was helpful in alerting the medical personnel. After an initial 1 mg of naloxone i.v. in increments of 0.1–0.2 mg, a continuous infusion of naloxone 0.4 mg h−1 i. v. was used to prevent a recurrence of the respiratory depression. The total dose of naloxone over an 8-h period was 3.6 mg.

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