Use of Demineralized Bone Matrix in Hindfoot Arthrodesis

Fifty-five patients considering a hindfoot fusion performed by the senior author over a 5-year period were given the choice of having the fusion augmented by either iliac crest bone graft or demineralized bone graft in a study of the relative efficacy of these 2 methods of bone grafting. Eleven patients underwent subtalar fusion (average age, 40.1 ± 14.0 years), and 44 had a triple arthrodesis (average age, 54.6 ± 19.2 years). The most common indications for surgery were posterior tibial tendon insufficiency and traumatic arthritis. There were no significant differences between groups regarding underlying disease, medications, or associated medical conditions. In isolated subtalar fusions, all 3 patients who received an iliac crest bone graft experienced healing, as did 7 of 8 patients who received demineralized bone graft. The eighth patient had a radiographic nonunion without clinical symptoms. Complete healing of triple arthrodeses was achieved in 13 of 15 patients who received an iliac crest bone graft and in 29 of 29 patients receiving a demineralized bone graft. There were no intergroup differences in the time to union, which generally was between 3 and 4 months. Intraoperative blood loss was significantly less with demineralized bone graft (33 ± 25 ml) than with iliac crest bone graft (206 ± 192 ml). This study demonstrated that demineralized bone graft aids arthrodesis at least as well as does iliac crest bone graft, without the increased blood loss, cost, and postoperative pain associated with iliac crest bone harvest.

[1]  A. Reddi,et al.  Initiation and promotion of bone differentiation by bone morphogenetic proteins , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[2]  P. Fugazzotto,et al.  THE USE OF DEMORALIZED FREEZE‐DRIED BONE AND NONRESORBABLE HYDROXYAPATITE IN THE TREATMENT OF BUCCAL DEHISCENCES AROUND IMPLANTS: CLINICAL REPORTS , 1993, Implant dentistry.

[3]  Fugazzotto Pa Ridge augmentation with titanium screws and guided tissue regeneration: technique and report of a case. , 1993 .

[4]  C. Lu,et al.  Experimental and clinical investigations of human insoluble bone matrix gelatin. A report of 24 cases. , 1993, Clinical orthopaedics and related research.

[5]  P. Fugazzotto Ridge augmentation with titanium screws and guided tissue regeneration: technique and report of a case. , 1993, The International journal of oral & maxillofacial implants.

[6]  J. Bardach,et al.  DEMINERALIZED PERFORATED BONE IMPLANTS IN CRANIOFACIAL SURGERY , 1992, The Journal of craniofacial surgery.

[7]  R. Wilkins,et al.  Giant cell tumor of bone treated by curettage, cementation, and bone grafting. , 1992, Orthopedics.

[8]  A. Reddi,et al.  Induction of Bone in Composites of Osteogenin and Porous Hydroxyapatite in Baboons , 1992, Plastic and reconstructive surgery.

[9]  J. Hsu,et al.  Triple Arthrodesis in the Treatment of Fixed Cavovarus Deformity in Adolescent Patients with Charcot-Marie-Tooth Disease , 1992, Foot & ankle.

[10]  Cook Sd,et al.  The use of a new form of allograft bone in implantation or osseointegrated dental implants--a preliminary report. , 1992 .

[11]  D. Mauldin,et al.  Triple Arthrodesis in Adults , 1991, Foot & ankle.

[12]  J. Connolly,et al.  Healing of a large nonossifying fibroma after grafting with bone matrix and marrow. A case report. , 1991, Clinical orthopaedics and related research.

[13]  J. Drennan,et al.  Long-term results of triple arthrodesis in Charcot-Marie-Tooth disease. , 1989, The Journal of bone and joint surgery. American volume.

[14]  J. Michelson,et al.  The effects of demineralized bone matrix and direct current on an “in vivo” culture of bone marrow cells , 1989, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[15]  R. Patterson Various factors involved in triple arthrodesis. , 1972, Clinical orthopaedics and related research.

[16]  V. Vahvanen Rheumatoid arthritis in the pantalar joints. A follow-up study of triple arthrodesis on 292 adult feet. , 1967, Acta orthopaedica Scandinavica.

[17]  F. Wilson,et al.  TRIPLE ARTHRODESIS. A STUDY OF THE FACTORS AFFECTING FUSION AFTER THREE HUNDRED AND ONE PROCEDURES. , 1965, The Journal of bone and joint surgery. American volume.

[18]  R. Patterson,et al.  Stabilizing Operations on the Foot: A Study of the Indications, Techniques Used, and End Results∗ , 1996, The Journal of bone and joint surgery. American volume.