A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein bindingElectronic supplementary information (ESI) available: pH dependence of europium emission spectra, stability screening details and relaxivity/pH plots for selected Gd complexes. See http://www.rsc.org/suppda

The high relaxivity of [GdaDO3A]3− (r1p = 12.3 mM−1 s−1, 20 MHz, 298 K, τm = 30 ns) in water is maintained in serum solution because the binding of protein and endogeneous anions, e.g. HCO3−/CO32− is suppressed by electrostatic repulsion.

[1]  Jide Xu,et al.  Syntheses and relaxation properties of mixed gadolinium hydroxypyridinonate MRI contrast agents. , 2000, Inorganic chemistry.

[2]  Jide Xu,et al.  A Tris-hydroxymethyl-Substituted Derivative of Gd-TREN-Me-3,2-HOPO: An MRI Relaxation Agent with Improved Efficiency , 2000 .

[3]  M. Botta,et al.  [GdPCP2A(H2O)2]-: A Paramagnetic Contrast Agent Designed for Improved Applications in Magnetic Resonance Imaging , 2000 .

[4]  Thorfinnur Gunnlaugsson,et al.  The Selectivity of Reversible Oxy-Anion Binding in Aqueous Solution at a Chiral Europium and Terbium Center: Signaling of Carbonate Chelation by Changes in the Form and Circular Polarization of Luminescence Emission , 2000 .

[5]  M. Port,et al.  Correlation of Water Exchange Rate with Isomeric Composition in Diastereoisomeric Gadolinium Complexes of Tetra(carboxyethyl)dota and Related Macrocyclic Ligands , 2000 .

[6]  R. Lauffer,et al.  Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications. , 1999, Chemical reviews.

[7]  Michael F. Tweedle,et al.  Synthesis, characterization, and crystal structure of the gadolinium(III) chelate of (1R,4R,7R)-.alpha.,.alpha.',.alpha.''-trimethyl-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3MA) , 1993 .

[8]  T. Norman,et al.  Hepato-biliary and renal excretion in mice of charged and neutral gadolinium complexes of cyclic tetra-aza-phosphinic and carboxylic acids. , 1993, Magnetic resonance imaging.

[9]  P. Wedeking,et al.  Dissociation of gadolinium chelates in mice: relationship to chemical characteristics. , 1992, Magnetic resonance imaging.