Photodynamic therapy in the treatment of intraepithelial neoplasia of the cervix, vulva and vagina

In the present review the authors analyzed the effectiveness of treatment of intraepithelial neoplasia I-II-III of the cervix (CIN), vulva (VIN) and vagina (VaIN) using photodynamic therapy (PDT). PDT is a method based on exposure to light after preliminary introduction of a photosensitizer into the body with the formation of singlet oxygen, which has a cytotoxic effect. The results of research on the use of PDT with various photosensitizers in the complex of therapeutic measures in patients with CIN, VIN, VaIN are presented. These data on the effectiveness and safety of PDT, ease of use allow this medical technology to be attributed to one of the most promising areas in the treatment of pathological intraepithelial changes of the cervix, vulva and vagina. The presented information allows focusing the attention on the PDT method and informing doctors and researchers about the broad prospects for applying this treatment method in clinical practice.

[1]  Lei Shi,et al.  Photodynamic therapy combined with carbon dioxide laser for low-grade vaginal intraepithelial neoplasia: A retrospective analysis. , 2020 .

[2]  Wang Xiuli,et al.  Photodynamic therapy combined with carbon dioxide laser for low-grade vaginal intraepithelial neoplasia: a retrospective analysis. , 2020, Photodiagnosis and photodynamic therapy.

[3]  G. Yin,et al.  Loop electrosurgical excision procedure followed by 5-aminolevulinic acid photodynamic therapy for cervical intraepithelial neoplasia, a report of six cases. , 2020, Photodiagnosis and photodynamic therapy.

[4]  Qingling Li,et al.  Efficacy of a New Therapeutic Option for Vulvar Intraepithelial Neoplasia: Superficial Shaving Combined With Photodynamic Therapy , 2019, Lasers in surgery and medicine.

[5]  A. TzerkovskyD..  ЛЕЙКОПЛАКИИ PHOTODYNAMIC THERAPY FOR VULVAR LEUKOPLAKIA , 2019 .

[6]  Д. Г. Курбатов,et al.  Андрология. Фармакология без ошибок под редакцией акад.РАН Камалова А.А. руководство для врачей , 2017 .

[7]  Ye-Kyu Park,et al.  Clinical efficacy of photodynamic therapy , 2016, Obstetrics & gynecology science.

[8]  Ю. Н. Перламутров,et al.  Пути повышения эффективности терапии наиболее распространенных бактериальных инфекций урогенитального тракта , 2016 .

[9]  Хужин Альфир Мисхатович,et al.  Гражданское право: учебник: в 2 т. , 2016 .

[10]  S. J. Kim,et al.  Photodynamic therapy for premalignant lesions of the vulva and vagina: A long‐term follow‐up study , 2015, Lasers in surgery and medicine.

[11]  E. Filonenko.  The history of development of fluorescence diagnosis and photodynamic therapy and their capabilities in oncology , 2015, Russian journal of general chemistry.

[12]  A. Feofanov,et al.  Experimental photodynamic therapy: 15 years of development , 2015, Russian Journal of General Chemistry.

[13]  P. Hillemanns,et al.  A randomized study of hexaminolevulinate photodynamic therapy in patients with cervical intraepithelial neoplasia 1/2. , 2015, American journal of obstetrics and gynecology.

[14]  C. Hurt,et al.  Activity, safety, and feasibility of cidofovir and imiquimod for treatment of vulval intraepithelial neoplasia (RT³VIN): a multicentre, open-label, randomised, phase 2 trial. , 2014, The Lancet. Oncology.

[15]  Sun Young Lee,et al.  Photodynamic therapy for management of cervical intraepithelial neoplasia II and III in young patients and obstetric outcomes , 2013, Lasers in surgery and medicine.

[16]  В. А. Дуванский,et al.  Фотодинамическая терапия в лечении неопухолевых заболеваний шейки матки , 2013 .

[17]  J. Reid,et al.  Proceedings of SPIE - The International Society for Optical Engineering , 2012 .

[18]  S. Eminović,et al.  Cervical cytology and HPV test in follow-up after conisation or LLETZ. , 2010, Collegium Antropologicum.

[19]  J. H. Price,et al.  Clinical and immunohistochemical assessment of vulval intraepithelial neoplasia following photodynamic therapy using a novel bioadhesive patch-type system loaded with 5-aminolevulinic acid. , 2009, Photodiagnosis and photodynamic therapy.

[20]  I. Staboulidou,et al.  Photodynamic diagnosis and therapy in gynecology. , 2009, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.

[21]  В. П. Голуб,et al.  Малярия в мегаполисе: современные аспекты диагностики, лечения и профилактики , 2007 .

[22]  S. Mordon,et al.  [The place of photodynamic therapy in gynecology]. , 2007, Gynecologie, obstetrique & fertilite.

[23]  H. Tsuda,et al.  Photodynamic Therapy for Cervical Intraepithelial Neoplasia , 2005, Oncology.

[24]  В. Г. Лихванцева,et al.  Возможности фотодинамической терапии в комплексном лечении новообразований орбиты , 2005 .

[25]  B. Śpiewankiewicz,et al.  Diagnostic value of the PDD method in evaluation of vulvar lesions. , 2005, European Journal of Gynaecological Oncology.

[26]  M. Fehr,et al.  Photodynamic therapy of vulvar and vaginal condyloma and intraepithelial neoplasia using topically applied 5‐aminolevulinic acid * , 2002, Lasers in surgery and medicine.

[27]  H Stepp,et al.  Photodynamic therapy of vulvar intraepithelial neoplasia using 5‐aminolevulinic acid , 2000, International journal of cancer.

[28]  L. I. Vorobĭova,et al.  [The diagnosis and treatment of background and precancerous diseases of the vulva]. , 1999, Likars'ka sprava.

[29]  J Moan,et al.  Lysosomes and Microtubules as Targets for Photochemotherapy of Cancer , 1997, Photochemistry and photobiology.

[30]  V. Fingar,et al.  Vascular effects of photodynamic therapy. , 1996, Journal of clinical laser medicine & surgery.

[31]  M. Sakamoto,et al.  [Photodynamic therapy (PDT) for early cervical cancer]. , 1996, Gan to kagaku ryoho. Cancer & chemotherapy.

[32]  Maria G. Galpern,et al.  First clinical results with a new drug for PDT , 1995, Other Conferences.

[33]  Valery I. Chissov,et al.  Photodynamic therapy of cancer with the photosensitizer PHOTOGEM , 1995, Other Conferences.