Surface Modification of Polypropylene Blood Oxygenator Membrane by Poly Ethylene Glycol Grafting

Blood oxygenators play key role in Extra Corporeal Membrane Oxygenator (ECMO) system using for patients with acute respiratory problems, immature fetal and also in open heart surgery. Interaction between blood and blood oxygenator polymeric membrane surface lead to fouling phenomena which have negative effect on performance of this important medical device. A modification comprising surface activation, PEG immersing and PEG graft polymerization carried out to provide acceptable blood oxygenator performance, blood compatibility and reduction in heparin consumption at the same time. Modified membranes characterized by FTIR, contact angle measurements and Atomic Force Microscopy (AFM) analyses. Blood compatibility of modified surface was also detected by SEM images. Results clearly indicate that modifying membranes by PEG is an effective way for anti-fouling properties. Water contact angel reduction from 110ْ to 72ْ shows hydrophilicity enhancement, roughness increasing from 15 to 20 and blood compatibility improvement was investigated by SEM and AFM analysis results respectively.

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