DELTA‐AMINOLEVULINIC ACID UPTAKE BY RABBIT BRAIN CEREBRAL CORTEX

Abstract— δ‐Aminolevulinic acid (δ‐ALA) was taken up by rabbit brain cortical slices to a concentration greater than that in the surrounding medium. The process responsible for this accumulation of δ‐ALA shows many of the properties characteristic of an active transport system. δ‐ALA is taken up by a system which exhibits some allosteric kinetic properties, and is specific to a relatively high degree.

[1]  M. Moore,et al.  The Effect of δ-Aminolaevulinic Acid on the Spontaneous Activity of Mice , 1973 .

[2]  G. Johnston,et al.  HIGH AFFINITY UPTAKE OF TRANSMITTERS: STUDIES ON THE UPTAKE OF l‐ASPARTATE, GABA, l‐GLUTAMATE AND GLYCINE IN CAT SPINAL CORD , 1973, Journal of neurochemistry.

[3]  M. Raiteri,et al.  Detectability of high and low affinity uptake systems for GABA and glutamate in rat brain slices and synaptosomes. , 1973, Life sciences. Pt. 1: Physiology and pharmacology.

[4]  J. Sive,et al.  Intracellular porphyrin concentration and erythrocyte life-span. , 2009, Scandinavian journal of haematology.

[5]  S. Snyder,et al.  High affinity uptake systems for glycine, glutamic and aspaspartic acids in synaptosomes of rat central nervous tissues. , 1972, Brain research.

[6]  C. J. Watson,et al.  Repression of the overproduction of porphyrin precursors in acute intermittent porphyria by intravenous infusions of hematin. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. Lieberman,et al.  Presynaptic neuromuscular inhibition by porphobilinogen and porphobilin. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[8]  D. Becker,et al.  The inhibition of red cell and brain ATPase by δ-aminolaevulinic acid , 1971 .

[9]  M. Pathak,et al.  Acute intermittent porphyria. Increased ALA-synthetase activity during an acute attack. , 1970, Brain : a journal of neurology.

[10]  M. Neal,et al.  THE UPTAKE OF [3H]GABA BY SLICES OF RAT CEREBRAL CORTEX , 1968, Journal of neurochemistry.

[11]  R. Albers Biochemical aspects of active transport. , 1967, Annual review of biochemistry.

[12]  E. Heinz Transport through biological membranes. , 1967, Annual review of physiology.

[13]  S. Granick,et al.  The induction in vitro of the synthesis of delta-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals. , 1966, The Journal of biological chemistry.

[14]  A. Lajtha,et al.  CEREBRAL AMINO ACID TRANSPORT IN VITRO–II REGIONAL DIFFERENCES IN AMINO ACID UPTAKE BY SLICES FROM THE CENTRAL NERVOUS SYSTEM OF THE RAT , 1965, Journal of neurochemistry.

[15]  V. Sardesai,et al.  A COMPARATIVE STUDY OF PORPHYRIN BIOSYNTHESIS IN DIFFERENT TISSUES. , 1964, Blood.

[16]  G. Collins,et al.  FACTORS AFFECTING THE EXCRETION OF PORPHYRIN PRECURSORS BY PATIENTS WITH ACUTE INTERMITTENT PORPHYRIA. I. THE EFFECT OF DIET. , 1964, Metabolism: clinical and experimental.

[17]  A. Benson,et al.  Studies on the biosynthesis of blood pigments. 4. The nature of the porphyrins formed on incubation of chicken erythrocyte preparations with glycine, delta-aminolaevulic acid or porphobilinogen. , 1956, The Biochemical journal.

[18]  S. Granick,et al.  THE OCCURRENCE AND DETERMINATION OF δ-AMINOLEVULINIC ACID AND PORPHOBILINOGEN IN URINE , 1956 .

[19]  D. Willoughby,et al.  δ-AMINOLÆVULIC ACID AND PORPHYRIA , 1956 .

[20]  S. Granick,et al.  Porphobilinogen and δ-Amino Levulinic Acid in Acute Porphyria , 1955 .

[21]  C. Rimington,et al.  Porphobilinogen: Chemical Constitution , 1953, Nature.