The promise of novel therapies to abolish gluten immunogenicity in celiac disease.
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[1] C. Wolf,et al. Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease. , 2021, Gastroenterology.
[2] K. Lundin,et al. Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning , 2021, Frontiers in Immunology.
[3] Tsung-Teh Wu,et al. TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study. , 2021, Gastroenterology.
[4] N. Ramsey,et al. Pathogenesis of IgE‐mediated food allergy and implications for future immunotherapeutics , 2021, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
[5] F. Koning,et al. Lack of relationship of AT1001 to zonulin and prehaptoglobin-2: clinical implications , 2020, Gut.
[6] M. I. Pinto-Sanchez,et al. Current and emerging therapies for coeliac disease , 2020, Nature Reviews Gastroenterology & Hepatology.
[7] D. Schuppan,et al. Gluten Degrading Enzymes for Treatment of Celiac Disease , 2020, Nutrients.
[8] Ryan M. Pearson,et al. Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease. , 2020, Gastroenterology.
[9] C. Khosla,et al. IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease , 2019, Nature.
[10] E. Macintyre,et al. Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study. , 2019, The lancet. Gastroenterology & hepatology.
[11] M. Scheinin,et al. Safety and efficacy of AMG 714 in adults with coeliac disease exposed to gluten challenge: a phase 2a, randomised, double-blind, placebo-controlled study. , 2019, The lancet. Gastroenterology & hepatology.
[12] J. Macdougall,et al. Randomised clinical trial: a placebo‐controlled study of subcutaneous or intradermal NEXVAX2, an investigational immunomodulatory peptide therapy for coeliac disease , 2019, Alimentary pharmacology & therapeutics.
[13] Ryan M. Pearson,et al. Overcoming challenges in treating autoimmuntity: Development of tolerogenic immune-modifying nanoparticles. , 2019, Nanomedicine : nanotechnology, biology, and medicine.
[14] Ryan M. Pearson,et al. Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation. , 2019, Journal of controlled release : official journal of the Controlled Release Society.
[15] D. Sanders,et al. Coeliac disease , 2018, The Lancet.
[16] R. Xavier,et al. Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies. , 2017, The lancet. Gastroenterology & hepatology.
[17] J. Murray,et al. Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial. , 2015, Gastroenterology.
[18] H. Kiyono,et al. Interleukin 15 and CD4⁺ T cells cooperate to promote small intestinal enteropathy in response to dietary antigen. , 2014, Gastroenterology.
[19] D. Schuppan,et al. Celiac disease: from pathogenesis to novel therapies. , 2009, Gastroenterology.
[20] L. Sollid,et al. Tissue-mediated control of immunopathology in coeliac disease , 2009, Nature Reviews Immunology.
[21] N. Cerf-Bensussan,et al. IL-15 Renders Conventional Lymphocytes Resistant to Suppressive Functions of Regulatory T Cells through Activation of the Phosphatidylinositol 3-Kinase Pathway1 , 2009, The Journal of Immunology.
[22] N. Rivard,et al. Polymeric binders suppress gliadin-induced toxicity in the intestinal epithelium. , 2009, Gastroenterology.
[23] N. Cerf-Bensussan,et al. Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease. , 2007, Gastroenterology.
[24] A. Fasano,et al. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. , 2007, The American journal of clinical nutrition.