Effect of glutamine-enriched total parenteral nutrition on inflammatory bowel disease

The aim of this study was to asses the effect of glutamine-supplemented total parenteral feeding on clinical and nutritional states in severe inflammatory bowel diseases (IBD). Twenty seven patients with severe IBD were qualified to total parenteral feeding with or without glutamine. The clinical, metabolic and nutritional improvements have been analyzed after 14-day treatment. Though, we were able to notice some improvements in hemoglobin and transferrin concentrations as well as nitrogen balance, it still cannot be strongly concluded that these effects were due to glutamine supplementation. There were any beneficial effects of glutamine on immunological, biochemical nor anthropometric parameters of nutritional status.

[1]  A. Griffiths,et al.  Enteral nutritional therapy for induction of remission in Crohn's disease. , 2007, The Cochrane database of systematic reviews.

[2]  P. Calder,et al.  Glutamine and the immune system , 1999, Amino Acids.

[3]  D. Wilmore,et al.  The effect of glutamine supplementation in patients following elective surgery and accidental injury. , 2001, The Journal of nutrition.

[4]  A. Buchman,et al.  Glutamine: commercially essential or conditionally essential? A critical appraisal of the human data. , 2001, The American journal of clinical nutrition.

[5]  A. Griffiths,et al.  Enteral nutritional therapy for inducing remission of Crohn's disease. , 2001, The Cochrane database of systematic reviews.

[6]  P. Stehle,et al.  Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study. , 2000, Clinical nutrition.

[7]  E. Levy,et al.  Nutrition as primary therapy in pediatric Crohn's disease: fact or fantasy? , 2000, The Journal of pediatrics.

[8]  A. Akobeng,et al.  Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease. , 2000, Journal of pediatric gastroenterology and nutrition.

[9]  M. Seo,et al.  The role of total parenteral nutrition in the management of patients with acute attacks of inflammatory bowel disease. , 1999, Journal of clinical gastroenterology.

[10]  Y. Liu,et al.  The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients. , 1999, JPEN. Journal of parenteral and enteral nutrition.

[11]  C. Lenders,et al.  Pediatric Parenteral Nutrition , 1999 .

[12]  J. Powell-Tuck,et al.  A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition , 1999, Gut.

[13]  R. Baldassano,et al.  Nutrition and inflammatory bowel disease. , 1999, Gastroenterology clinics of North America.

[14]  R. Brummer,et al.  Nutrition and inflammatory bowel disease: an update. , 1999, Scandinavian journal of gastroenterology. Supplement.

[15]  D. Wilmore,et al.  Role of glutamine in immunologic responses. , 1998, Nutrition.

[16]  M. Shinozaki,et al.  Excess glutamine exacerbates trinitrobenzenesulfonic acid-induced colitis in rats , 1997, Diseases of the colon and rectum.

[17]  T. Fujita,et al.  Efficacy of glutamine‐enriched enteral nutrition in an experimental model of mucosal ulcerative colitis , 1995, The British journal of surgery.

[18]  S. Phillips,et al.  Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study. , 1993, Mayo Clinic proceedings.

[19]  J. Arends,et al.  Glutamine and the preservation of gut integrity , 1993, The Lancet.

[20]  M. Elia,et al.  Amino acid metabolism in muscle and in the whole body of man before and after ingestion of a single mixed meal. , 1989, The American journal of clinical nutrition.

[21]  D. Wilmore,et al.  Long-term total parenteral nutrition with growth, development, and positive nitrogen balance. , 1968, Surgery.