Molecular aspects of lipoic acid in the prevention of diabetes complications.

[1]  A. Vincent,et al.  Oxidative Stress and Programmed Cell Death in Diabetic Neuropathy , 2002, Annals of the New York Academy of Sciences.

[2]  M. Cybulsky,et al.  NF-κB: pivotal mediator or innocent bystander in atherogenesis? , 2001 .

[3]  M. Hanefeld,et al.  Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy. , 1999, Diabetes care.

[4]  S. Jacob,et al.  Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. , 1999, Free radical biology & medicine.

[5]  Michael Karin,et al.  Is NF‐κB the sensor of oxidative stress? , 1999 .

[6]  K. Usadel,et al.  The effect of alpha-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy. , 1999, Microvascular research.

[7]  A. Rudich,et al.  Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes , 1999, Diabetologia.

[8]  E. Feldman,et al.  Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy. , 1999, European journal of pharmacology.

[9]  B. Halliwell,et al.  alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. , 1999, Free radical biology & medicine.

[10]  C. Sen,et al.  Cytokine-induced glucose uptake in skeletal muscle: redox regulation and the role of α-lipoic acid. , 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

[11]  B. Halliwell,et al.  Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus , 1999, FEBS letters.

[12]  A. Rudich,et al.  Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. , 1999, Metabolism: clinical and experimental.

[13]  R. Hermann,et al.  Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data. , 1999, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[14]  L. Gille,et al.  Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone. , 1999, Archives of biochemistry and biophysics.

[15]  L. Packer,et al.  The inhibitory effects of lipoic compounds on mammalian pyruvate dehydrogenase complex and its catalytic components. , 1999, Free radical biology & medicine.

[16]  C. Cobelli,et al.  alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. , 1999, Diabetes care.

[17]  M. Cotter,et al.  Effects of diabetes and treatment with the antioxidant α-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats , 1999, Diabetologia.

[18]  H. Tritschler,et al.  Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve , 1999, Journal of the Neurological Sciences.

[19]  C. Sen,et al.  α-Lipoic Acid: Cell Regulatory Function and Potential Therapeutic Implications , 1999 .

[20]  P. Varalakshmi,et al.  Protective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidation. , 1999, Pharmacological research.

[21]  L. Packer,et al.  Antioxidant food supplements in human health , 1999 .

[22]  B. Isermann,et al.  Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kB , 1999, Diabetologia.

[23]  H. Tritschler,et al.  α-Lipoic acid reduces expression of vascular cell adhesion molecule-1 and endothelial adhesion of human monocytes after stimulation with advanced glycation end products , 1999 .

[24]  H. Tritschler,et al.  Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. , 1998, International journal of clinical pharmacology and therapeutics.

[25]  J. Trevithick,et al.  Modelling cortical cataractogenesis XX. In vitro effect of α‐lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis , 1998, Biochemistry and molecular biology international.

[26]  C. Sen,et al.  Antioxidant regulation of phorbol ester-induced adhesion of human Jurkat T-cells to endothelial cells. , 1998, Free radical biology & medicine.

[27]  C. Sen Redox signaling and the emerging therapeutic potential of thiol antioxidants. , 1998, Biochemical pharmacology.

[28]  L. Packer α-Lipoic Acid: A Metabolic Antioxidant Which Regulates NF-κB Signal Transduction and Protects Against Oxidative Injury , 1998 .

[29]  H. Tritschler,et al.  Effects of α-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids , 1998, Diabetologia.

[30]  C. Gleiter,et al.  Gastric emptying in patients with insulin dependent diabetes mellitus and bioavailability of thioctic acid-enantiomers. , 1998, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[31]  T. Luther,et al.  Advanced Glycation End Product-Induced Activation of NF-κB is Suppressed by α-Lipoic Acid in Cultured Endothelial Cells , 1997, Diabetes.

[32]  H. Tritschler,et al.  The Roles of Oxidative Stress and Antioxidant Treatment in Experimental Diabetic Neuropathy , 1997, Diabetes.

[33]  F. Gries,et al.  α-Lipoic Acid in the Treatment of Diabetic Peripheral and Cardiac Autonomic Neuropathy , 1997, Diabetes.

[34]  S. Jacob,et al.  Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. , 1997, The American journal of physiology.

[35]  B. Halliwell,et al.  Relationships between plasma measures of oxidative stress and metabolic control in NIDDM , 1997, Diabetologia.

[36]  F. Gries,et al.  Effects of Treatment With the Antioxidant α-Lipoic Acid on Cardiac Autonomic Neuropathy in NIDDM Patients: A 4-month randomized controlled multicenter trial (DEKAN Study) , 1997, Diabetes Care.

[37]  J. Ohlrogge,et al.  Why do mitochondria synthesize fatty acids? Evidence for involvement in lipoic acid production. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[38]  C. Sen,et al.  Modulation of cellular reducing equivalent homeostasis by alpha-lipoic acid. Mechanisms and implications for diabetes and ischemic injury. , 1997, Biochemical pharmacology.

[39]  J. Zempleni,et al.  Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-l-sulfoxide in human urine. , 1997, The American journal of clinical nutrition.

[40]  C. Sen,et al.  Regulation of Cellular Thiols in Human Lymphocytes by α-Lipoic Acid: A Flow Cytometric Analysis , 1997 .

[41]  J. Cronan,et al.  [19] Biosynthesis of lipoic acid and posttranslational modification with lipoic acid in Escherichia coli , 1997 .

[42]  C. Sen,et al.  Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization , 1997, BioFactors.

[43]  A. Bast,et al.  The role of lipoic acid in the treatment of diabetic polyneuropathy. , 1997, Drug metabolism reviews.

[44]  S. Jacob,et al.  Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. , 2009, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[45]  A. Klip,et al.  Stimulation of Glucose Uptake by the Natural Coenzyme α-Lipoic Acid/Thioctic Acid: Participation of Elements of the Insulin Signaling Pathway , 1996, Diabetes.

[46]  S. Jacob,et al.  The Antioxidant α-Lipoic Acid Enhances Insulin-Stimulated Glucose Metabolism in Insulin-Resistant Rat Skeletal Muscle , 1996, Diabetes.

[47]  G. Gibbons,et al.  Molecular Therapies for Vascular Diseases , 1996, Science.

[48]  R. Hermann,et al.  Enantioselective pharmacokinetics and bioavailability of different racemic α-lipoic acid formulations in healthy volunteers , 1996 .

[49]  R. Knuechel,et al.  Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. , 1996, The Journal of clinical investigation.

[50]  G. Paolisso,et al.  Oxidative Stress and Diabetic Vascular Complications , 1996, Diabetes Care.

[51]  T. Collins,et al.  Expression of NF-kappa B and I kappa B-alpha by aortic endothelium in an arterial injury model. , 1996, The American journal of pathology.

[52]  U. Gundert-Remy,et al.  Influence of food intake on the bioavailability of thioctic acid enantiomers , 1996, European Journal of Clinical Pharmacology.

[53]  M. Hanefeld,et al.  Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). , 1995, Diabetologia.

[54]  H. Tritschler,et al.  Decrease of red cell membrane fluidity and -SH groups due to hyperglycemic conditions is counteracted by alpha-lipoic acid. , 1995, Archives of biochemistry and biophysics.

[55]  J. Trevithick,et al.  Modelling cortical cataractogenesis 17: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis. , 1995, Biochemistry and molecular biology international.

[56]  B. Bravenboer,et al.  The role of oxidative stress in neuropathy and other diabetic complications. , 1995, Diabetes/metabolism reviews.

[57]  H. Tritschler,et al.  Dose/response curves of lipoic acid R-and S-forms in the working rat heart during reoxygenation: superiority of the R-enantiomer in enhancement of aortic flow. , 1995, Journal of molecular and cellular cardiology.

[58]  L. Packer,et al.  Biothiols in Health and Disease , 1995 .

[59]  S. Jacob,et al.  Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. , 1995, Arzneimittel-Forschung.

[60]  H. Tritschler,et al.  Lipoic Acid Improves Nerve Blood Flow, Reduces Oxidative Stress, and Improves Distal Nerve Conduction in Experimental Diabetic Neuropathy , 1995, Diabetes Care.

[61]  H. Tritschler,et al.  Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? , 1995, Biochemical pharmacology.

[62]  L. Packer,et al.  Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. , 1995, Free radical biology & medicine.

[63]  H. Borbe,et al.  Absorption of [7,8-14C]rac-a-lipoic acid from in situ ligated segments of the gastrointestinal tract of the rat. , 1995, Arzneimittel-Forschung.

[64]  L. Packer,et al.  Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency. , 1994, Biochemical and biophysical research communications.

[65]  G. Rubanyi,et al.  The role of endothelium in cardiovascular homeostasis and diseases. , 1993, Journal of cardiovascular pharmacology.

[66]  S. Wolff Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. , 1993, British medical bulletin.

[67]  C. Klaassen,et al.  Effect of lipoic acid on biliary excretion of glutathione and metals. , 1992, Toxicology and applied pharmacology.

[68]  L. Packer,et al.  Lipoate prevents glucose-induced protein modifications. , 1992, Free radical research communications.

[69]  J. Baynes Role of Oxidative Stress in Development of Complications in Diabetes , 1991, Diabetes.

[70]  M. Cybulsky,et al.  Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. , 1991, Science.

[71]  W. Dimpfel,et al.  Thioctic acid induces dose-dependent sprouting of neurites in cultured rat neuroblastoma cells. , 1990, Developmental pharmacology and therapeutics.

[72]  R. Dean,et al.  Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing. , 1988, The Biochemical journal.

[73]  A. Cerami,et al.  Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. , 1988, The New England journal of medicine.

[74]  L. Oberley Free radicals and diabetes. , 1988, Free radical biology & medicine.

[75]  J. Jörg,et al.  [Drug treatment of diabetic polyneuropathy with alpha-lipoic acid or vitamin B preparations. A clinical and neurophysiologic study]. , 1988, Der Nervenarzt.

[76]  S. Blumenthal Inhibition of gluconeogenesis in rat liver by lipoic acid. Evidence for more than one site of action. , 1984, The Biochemical journal.

[77]  D. B. Mccormick,et al.  Lipoic acid metabolism in the rat. , 1976, Archives of biochemistry and biophysics.

[78]  N. Haugaard,et al.  Stimulation of glucose utilization by thioctic acid in rat diaphragm incubated in vitro. , 1970, Biochimica et biophysica acta.

[79]  R. H. Bowman,et al.  Effect of DL-α-lipoic acid on the citrate concentration and phosphofructokinase activity of perfused hearts from normal and diabetic rats , 1970 .

[80]  P. Jocelyn The standard redox potential of cysteine-cystine from the thiol-disulphide exchange reaction with glutathione and lipoic acid. , 1967, European journal of biochemistry.

[81]  H. R. Rosenberg,et al.  Effect of α-lipoic acid on vitamin C and vitamin E deficiencies , 1959 .

[82]  L. Reed The chemistry and function of lipoic acid. , 2006, Advances in enzymology and related subjects of biochemistry.

[83]  L. Reed,et al.  Crystalline alpha-lipoic acid; a catalytic agent associated with pyruvate dehydrogenase. , 1951, Science.

[84]  W. H. Peterson,et al.  Growth factors for bacteria: Fractionation and properties of an accessory factor for lactic acid bacteria. , 1937, The Biochemical journal.