Sodium bicarbonate attenuates pain on skin infiltration with lidocaine, with or without epinephrine.

Anesthetics produce pain on skin infiltration (1,2). The relation of this local anesthetic-induced pain to pH of the local anesthetic solution has, however, not been evaluated. Commercial preparations of local anesthetics are prepared as acidic solutions of the salts to promote solubility and stabil

[1]  M. Hilgier Alkalinization of Bupivacaine for Brachial Plexus Block , 1985, Regional Anesthesia & Pain Medicine.

[2]  C. Warfield,et al.  The measurement of pain. , 1988, Hospital practice.

[3]  R. Morris,et al.  A Controlled Trial of Pain on Skin Infiltration with Local Anaesthetics , 1984, Anaesthesia and intensive care.

[4]  C. Mcleskey pH of local anesthetic solutions. , 1980, Anesthesia and analgesia.

[5]  R. Johns,et al.  Comparison of pH‐Adjusted Lidocaine Solutions for Epidural Anesthesia , 1986, Anesthesia and analgesia.

[6]  R. Vaughan,et al.  Comparison of compounds used for intradermal anesthesia. , 1976, Anesthesiology.

[7]  E. C. Huskisson,et al.  Graphic representation of pain , 1976, Pain.

[8]  M Rosen,et al.  The reliability of a linear analogue for evaluating pain , 1976, Anaesthesia.