Journal Pre-proof Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue

and few studies have focused on the role of glycolytic enzymes in regulating adipose tissue function. We generated mouse models with specific deletion of the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) from adipose tissue. Deletion of Pgam1 from both BAT and WAT promoted whitening of BAT with beiging of visceral WAT, whereas deletion of Pgam1 from BAT alone led to whitening of BAT without beiging of WAT. Our results demonstrate a potential role of glycolytic enzymes in beiging of visceral WAT and suggest that PGAM1 would be a novel therapeutic target in obesity and diabetes. Centrifugation performed after centrifugally 50μl μM capillary All CE-TOF/MS experiments were performed using an Agilent Capillary Electrophoresis equipped with an Agilent an Agilent isocratic HPLC Agilent an Agilent

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