A High-Resolution C. elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue

[1]  Heidi N. Fridolfsson,et al.  Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei , 2010, The Journal of cell biology.

[2]  C. Rongo,et al.  EHBP-1 Functions with RAB-10 during Endocytic Recycling in Caenorhabditis elegans , 2010, Molecular biology of the cell.

[3]  A. Hyman,et al.  Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions , 2010, The Journal of cell biology.

[4]  R. Durbin,et al.  Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins , 2010, Science.

[5]  R. Durbin,et al.  Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes , 2010, Nature.

[6]  C. Conrad,et al.  Automated microscopy for high-content RNAi screening , 2010, The Journal of cell biology.

[7]  Gary D Bader,et al.  The Genetic Landscape of a Cell , 2010, Science.

[8]  Kimberly Van Auken,et al.  WormBase: a comprehensive resource for nematode research , 2009, Nucleic Acids Res..

[9]  Sean R. Collins,et al.  From information to knowledge: new technologies for defining gene function , 2009, Nature Methods.

[10]  D. Hall,et al.  A ZYG-12–dynein interaction at the nuclear envelope defines cytoskeletal architecture in the C. elegans gonad , 2009, The Journal of cell biology.

[11]  T. Schedl,et al.  Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development , 2009, Proceedings of the National Academy of Sciences.

[12]  K. Oegema,et al.  Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches. , 2009, Molecular biology of the cell.

[13]  K. Gunsalus,et al.  Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network , 2009, Nature Methods.

[14]  Tao Liu,et al.  Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology , 2009, Genome Biology.

[15]  Sean R. Collins,et al.  A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. , 2008, Molecular cell.

[16]  Huey-Ling Kao,et al.  Browsing Multidimensional Molecular Networks with the Generic Network Browser (N‐Browse) , 2008, Current protocols in bioinformatics.

[17]  Sean R. Collins,et al.  A comprehensive strategy enabling high-resolution functional analysis of the yeast genome , 2008, Nature Methods.

[18]  Lilia M. Iakoucheva,et al.  A Protein Domain-Based Interactome Network for C. elegans Early Embryogenesis , 2008, Cell.

[19]  K. Gunsalus.  A Caenorhabditis elegans genetic-interaction map wiggles into view , 2008, Journal of biology.

[20]  A. Audhya,et al.  UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans. , 2008, Developmental biology.

[21]  T. Schedl,et al.  Multiple Functions and Dynamic Activation of MPK-1 Extracellular Signal-Regulated Kinase Signaling in Caenorhabditis elegans Germline Development , 2007, Genetics.

[22]  C. Bakal,et al.  Quantitative Morphological Signatures Define Local Signaling Networks Regulating Cell Morphology , 2007, Science.

[23]  H. Bussey,et al.  Exploring genetic interactions and networks with yeast , 2007, Nature Reviews Genetics.

[24]  R. Wollman,et al.  Genes Required for Mitotic Spindle Assembly in Drosophila S2 Cells , 2007, Science.

[25]  Grant W. Brown,et al.  Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map , 2007, Nature.

[26]  F. Piano,et al.  C. elegans network biology: a beginning. , 2006, WormBook : the online review of C. elegans biology.

[27]  N. Perrimon,et al.  Drosophila genome-wide RNAi screens: are they delivering the promise? , 2006, Cold Spring Harbor symposia on quantitative biology.

[28]  Sean R. Collins,et al.  Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile , 2005, Cell.

[29]  A. Puisieux,et al.  C. elegans homologue of the Caf1 gene, which encodes a subunit of the CCR4-NOT complex, is essential for embryonic and larval development and for meiotic progression. , 2005, Gene.

[30]  J. Kimble,et al.  Germline proliferation and its control. , 2005, WormBook : the online review of C. elegans biology.

[31]  Marc Vidal,et al.  Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis , 2005, Nature.

[32]  John R Yates,et al.  Identification and characterization of novel nicotinic receptor‐associated proteins in Caenorhabditis elegans , 2005, The EMBO journal.

[33]  D. Vassilatis,et al.  Functional analysis of MRG-1: the ortholog of human MRG15 in Caenorhabditis elegans. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[34]  K. Gunsalus,et al.  Autosomal Genes of Autosomal/X-Linked Duplicated Gene Pairs and Germ-Line Proliferation in Caenorhabditis elegans , 2005, Genetics.

[35]  A. Coulson,et al.  Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans , 2005, Nature.

[36]  F. Piano,et al.  New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones. , 2005, Genome research.

[37]  Xiaojiang Xu,et al.  Linking integrin to IP3 signaling is important for ovulation in Caenorhabditis elegans , 2005, FEBS letters.

[38]  David E Hill,et al.  Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. , 2004, Genome research.

[39]  Norbert Perrimon,et al.  Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets , 2004, PLoS biology.

[40]  P. O’Farrell,et al.  Terminal Cytokinesis Events Uncovered after an RNAi Screen , 2004, Current Biology.

[41]  John R Yates,et al.  A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. , 2004, Genes & development.

[42]  Min Han,et al.  The Caenorhabditis elegans Nuclear Receptor Gene nhr-25 Regulates Epidermal Cell Development , 2004, Molecular and Cellular Biology.

[43]  G. Walker,et al.  HRP-2, a heterogeneous nuclear ribonucleoprotein, is essential for embryogenesis and oogenesis in Caenorhabditis elegans. , 2004, Experimental cell research.

[44]  J. Yates,et al.  Dissection of the Mammalian Midbody Proteome Reveals Conserved Cytokinesis Mechanisms , 2004, Science.

[45]  S. L. Wong,et al.  A Map of the Interactome Network of the Metazoan C. elegans , 2004, Science.

[46]  W. Dalton,et al.  The proteasome. , 2004, Seminars in oncology.

[47]  K. Oegema,et al.  KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. , 2003, Genes & development.

[48]  Andrew G Fraser,et al.  Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions , 2003, PLoS biology.

[49]  Darren A. Natale,et al.  The COG database: an updated version includes eukaryotes , 2003, BMC Bioinformatics.

[50]  T. C. Evans,et al.  Translational repression of a C. elegans Notch mRNA by the STAR/KH domain protein GLD-1 , 2003, Development.

[51]  W. Song,et al.  Vacuolar-type H+-ATPase E subunit is required for embryogenesis and yolk transfer in Caenorhabditis elegans. , 2003, Gene.

[52]  T. Kawano,et al.  Corrigendum to “MRG-1, a mortality factor-related chromodomain protein, is required maternally for primordial germ cells to initiate mitotic proliferation in C. elegans” [Mech. Dev. 114 (2002) 61–69] , 2003, Mechanisms of Development.

[53]  Y. Dong,et al.  Systematic functional analysis of the Caenorhabditis elegans genome using RNAi , 2003, Nature.

[54]  Gary D. Bader,et al.  An automated method for finding molecular complexes in large protein interaction networks , 2003, BMC Bioinformatics.

[55]  F. Piano,et al.  Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans , 2002, Current Biology.

[56]  M. Labouesse,et al.  Identification of 1088 new transposon insertions of Caenorhabditis elegans: a pilot study toward large-scale screens. , 2002, Genetics.

[57]  T. Kawano,et al.  MRG-1, a mortality factor-related chromodomain protein, is required maternally for primordial germ cells to initiate mitotic proliferation in C. elegans , 2002, Mechanisms of Development.

[58]  M. Jantsch,et al.  The Aurora B Kinase AIR-2 Regulates Kinetochores during Mitosis and Is Required for Separation of Homologous Chromosomes during Meiosis , 2002, Current Biology.

[59]  A. Golden,et al.  Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I. , 2002, Genetics.

[60]  H. Horvitz,et al.  unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. , 2001, Development.

[61]  Titia Sijen,et al.  On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing , 2001, Cell.

[62]  P. Zipperlen,et al.  Roles for 147 embryonic lethal genes on C.elegans chromosome I identified by RNA interference and video microscopy , 2001, The EMBO journal.

[63]  R. Lin,et al.  Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C. elegans. , 2001, Developmental cell.

[64]  M Mochii,et al.  Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[65]  Elizabeth Casey,et al.  Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. , 2001, Genetics.

[66]  Yuji Kohara,et al.  Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi , 2001, Current Biology.

[67]  L. Stein,et al.  RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans , 2000, Current Biology.

[68]  Sebastian A. Leidel,et al.  Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III , 2000, Nature.

[69]  P. Zipperlen,et al.  Functional genomic analysis of C. elegans chromosome I by systematic RNA interference , 2000, Nature.

[70]  Morris F. Maduro,et al.  Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. , 1995, Genetics.