Patterns of anti‐inflammatory drug use and risk of dementia: a matched case–control study

There is limited primary‐care‐based evidence about a potential association between anti‐inflammatory therapy and dementia subtypes. The present study addressed this limitation by using electronic health records from a large primary care database.

[1]  K J Rothman,et al.  No Adjustments Are Needed for Multiple Comparisons , 1990, Epidemiology.

[2]  N. Delanty,et al.  Risk of Alzheimer's disease and duration of NSAID use , 1998, Neurology.

[3]  Šimon Scharf,et al.  A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease , 1999, Neurology.

[4]  L. Thal,et al.  A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study. , 2000, Neurology.

[5]  F. Angeleri,et al.  General practitioners facing dementia: are they fully prepared? , 2004, Neurological Sciences.

[6]  M. Etminan,et al.  Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies , 2003, BMJ : British Medical Journal.

[7]  K. Davis,et al.  Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. , 2003, JAMA.

[8]  L. Launer Nonsteroidal anti-inflammatory drugs and Alzheimer disease: what's next? , 2003, JAMA.

[9]  H. Feldman,et al.  Treatment of Alzheimer's disease; current status and new perspectives , 2003, The Lancet Neurology.

[10]  R. Green,et al.  Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial , 2007, Neurology.

[11]  J. Manson,et al.  Low dose aspirin and cognitive function in the women's health study cognitive cohort , 2007, BMJ : British Medical Journal.

[12]  A. Hofman,et al.  Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs and risk of stroke. , 2008, Archives of internal medicine.

[13]  R. Charlton,et al.  Data Resources for Investigating Drug Exposure during Pregnancy and Associated Outcomes , 2008, Drug safety.

[14]  T. Rea,et al.  NSAID use and dementia risk in the Cardiovascular Health Study* , 2008, Neurology.

[15]  R. Green,et al.  Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. , 2008, Archives of neurology.

[16]  M. Gulliford,et al.  Selection of Medical Diagnostic Codes for Analysis of Electronic Patient Records. Application to Stroke in a Primary Care Database , 2009, PloS one.

[17]  P. Pasqualetti,et al.  A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer’s disease , 2009, Aging clinical and experimental research.

[18]  R. Veerhuis,et al.  Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease , 2010, Neurodegenerative Diseases.

[19]  P. Gorelick Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials , 2010, Annals of the New York Academy of Sciences.

[20]  M. Egger,et al.  Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis , 2011, BMJ : British Medical Journal.

[21]  S. Jick,et al.  NSAID use and risk of Parkinson disease: a population‐based case‐control study , 2011, European journal of neurology.

[22]  K. Rothman,et al.  Non-steroidal anti-inflammatory drug use and risk of atrial fibrillation or flutter: population based case-control study , 2011, BMJ : British Medical Journal.

[23]  M. Gulliford,et al.  Validity of cancer diagnosis in a primary care database compared with linked cancer registrations in England. Population-based cohort study. , 2012, Cancer epidemiology.

[24]  J. Lindsay,et al.  Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer’s disease , 2012, Alzheimer's & Dementia.

[25]  N. Tabet,et al.  Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. , 2012, The Cochrane database of systematic reviews.

[26]  T. Schnitzer,et al.  Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials , 2013, BDJ.

[27]  C. Wolfe,et al.  Is Sodium Valproate, an HDAC inhibitor, associated with reduced risk of stroke and myocardial infarction? A nested case–control study , 2014, Pharmacoepidemiology and drug safety.

[28]  A. Pariente,et al.  Benzodiazepine use and risk of Alzheimer’s disease: case-control study , 2014, BMJ : British Medical Journal.

[29]  Natalia Beloff,et al.  Exploiting the potential of large databases of electronic health records for research using rapid search algorithms and an intuitive query interface , 2013, J. Am. Medical Informatics Assoc..

[30]  A. Lbert,et al.  Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease , 2022 .