A combined time-domain diffuse fluorescence and optical tomography system for breast tumor detection

A combined time-domain diffuse fluorescence and optical tomographic system is proposed based on the multi-channel time-correlated single-photon counting (TCSPC) technique, aiming at enhancing the reliability of breast diffuse optical tomography. The system equipped with two pulsed laser diodes at wavelengths of 780 nm and 830 nm that are specific to the maximal excitation and emission of the FDA-approved ICG dye, and works with a 4-channel TCSPC module to acquire the temporal distributions of the light re-emissions 32 boundary sites of tissues in a tandem serial-to-parallel mode. The performance and efficacy of the system are investigated with phantom experiments for diffuse optical tomography (DOT), as well as fluorescence-guided DOT.

[1]  Davide Contini,et al.  A compact time-resolved system for near infrared spectroscopy based on wavelength space multiplexing. , 2010, The Review of scientific instruments.

[2]  Brian W Pogue,et al.  Near-infrared tomography of breast cancer hemoglobin, water, lipid, and scattering using combined frequency domain and cw measurement. , 2010, Optics letters.

[3]  B. Pogue,et al.  Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization. , 2007, Optics express.

[4]  Zhao Hui-juan.  A Linear Featured-data Scheme for Image Reconstruction in Time-domain Fluorescence Molecular Tomography , 2008 .

[5]  Simon R. Arridge,et al.  Calibration techniques and datatype extraction for time-resolved optical tomography , 2000 .

[6]  Hamid Dehghani,et al.  Magnetic-resonance-imaging-coupled broadband near-infrared tomography system for small animal brain studies. , 2005, Applied optics.

[7]  Jia Wang,et al.  MR Water Quantitative Priors Improves the Accuracy of Optical Breast Imaging , 2011, IEEE Transactions on Medical Imaging.

[8]  M. A. van den Bosch,et al.  Optical imaging of the breast , 2008, Cancer imaging : the official publication of the International Cancer Imaging Society.

[9]  F. Gao,et al.  Time-Resolved Diffuse Optical Tomography Using a Modified Generalized Pulse Spectrum Technique , 2002 .

[10]  Martin Schweiger,et al.  Electrical Impedance and Diffuse Optical Tomography Reconstruction Software , 1999 .

[11]  K. Paulsen,et al.  High-resolution near-infrared tomographic imaging simulations of the rat cranium by use of a priori magnetic resonance imaging structural information. , 1998, Optics letters.

[12]  M. Huang,et al.  Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction. , 2005, Radiology.

[13]  Alessandro Torricelli,et al.  Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification. , 2009, Optics express.

[14]  Timothy J Rudge,et al.  Full-wavelet approach for fluorescence diffuse optical tomography with structured illumination. , 2010, Optics letters.

[15]  R. Cubeddu,et al.  Multi-channel time-resolved system for functional near infrared spectroscopy. , 2006, Optics express.

[16]  Daqing Piao,et al.  Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate, part II: experimental demonstration. , 2008, Optics express.