The clinical rehabilitation of spine and spinal cord disorders: detection and evaluation using SPECT/CT

Spine-related disorders are caused by several factors including (1) spinal nerve/visceral nerve stimulation by perivertebral aseptic inflammation, (2) spinal nerve/visceral nerve compression by injured periverterbal soft tissue, dislocated perivertebral small joint, and proliferative/degenerative tissue and, (3) secondary damage to the spinal cord, peripheral nerve, vessels and autonomic nerve, which further stimulate nerve root sheath and surrounding pain-carrying nerve fibers. In many cases, the source of pain cannot be detected by standard image modalities. Particularly in anatomically complex regions like the spine, SPECT/CT can be helpful for some aspects by introducing a metabolical dimension to the classical way of morphology-based diagnostic. The aim of the present review was to give an overview of the adoption of SPECT/CT in a clinical spine-focused setting.

[1]  Torsten Kuwert,et al.  SPECT-guided CT for evaluating foci of increased bone metabolism classified as indeterminate on SPECT in cancer patients. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[2]  A. Groves,et al.  16-Detector multislice CT–skeletal scintigraphy image co-registration , 2004, Nuclear medicine communications.

[3]  S. Herring,et al.  Expert opinion and controversies in sports and musculoskeletal medicine: the diagnosis and treatment of spondylolysis in adolescent athletes. , 2007, Archives of physical medicine and rehabilitation.

[4]  M. Batt,et al.  The value of combining single photon emission computerised tomography and computerised tomography in the investigation of spondylolysis , 2004, European Spine Journal.

[5]  D. Capen,et al.  Assessment of pseudarthrosis in pedicle screw fusion: a prospective study comparing plain radiographs, flexion/extension radiographs, CT scanning, and bone scintigraphy with operative findings. , 1996, Journal of spinal disorders.

[6]  M. Harris,et al.  Undiagnosed fractures in severely injured children and young adults. Identification with technetium imaging. , 1994, The Journal of bone and joint surgery. American volume.

[7]  A. Hiwatashi,et al.  Vertebroplasty: cement leakage into the disc increases the risk of new fracture of adjacent vertebral body. , 2004, AJNR. American journal of neuroradiology.

[8]  Andrew S. Lee,et al.  Risk Factors of New Compression Fractures in Adjacent Vertebrae after Percutaneous Vertebroplasty , 2007, Asian spine journal.

[9]  Torsten Kuwert,et al.  Skeletal SPECT/CT of the peripheral extremities. , 2010, AJR. American journal of roentgenology.

[10]  Robert H. Martin,et al.  Role of SPECT in differentiating malignant from benign lesions in the lower thoracic and lumbar vertebrae. , 1993, Radiology.

[11]  M. Minoves Bone and joint sports injuries: the role of bone scintigraphy , 2003, Nuclear medicine communications.

[12]  M. Syed,et al.  New symptomatic vertebral compression fractures within a year following vertebroplasty in osteoporotic women. , 2005, AJNR. American journal of neuroradiology.

[13]  H. Amthauer,et al.  99mTc-besilesomab (Scintimun®) in peripheral osteomyelitis: comparison with 99mTc-labelled white blood cells , 2011, European Journal of Nuclear Medicine and Molecular Imaging.

[14]  V. Goel,et al.  MRI Signal Changes of the Pedicle as an Indicator for Early Diagnosis of Spondylolysis in Children and Adolescents: A Clinical and Biomechanical Study , 2006, Spine.

[15]  O. Ratib,et al.  SPECT/CT in Differentiation of Pseudarthrosis From Other Causes of Back Pain in Lumbar Spinal Fusion: Report on 10 Consecutive Cases , 2012, Clinical nuclear medicine.

[16]  A. Engel,et al.  SPECT/CT using 67Ga and 111In-labeled leukocyte scintigraphy for diagnosis of infection. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[17]  N. Matsunaga,et al.  Malignant versus benign vertebral compression fractures: can we use bone SPECT as a substitute for MR imaging? , 2011, Nuclear medicine communications.

[18]  R. Deyo,et al.  Are Lumbar Spine Reoperation Rates Falling With Greater Use of Fusion Surgery and New Surgical Technology? , 2007, Spine.

[19]  J. Cauley,et al.  Risk of Mortality Following Clinical Fractures , 2000, Osteoporosis International.

[20]  C. Love,et al.  Radionuclide bone imaging: an illustrative review. , 2003, Radiographics : a review publication of the Radiological Society of North America, Inc.

[21]  E. Rutherford,et al.  Lumbar spine fusion and stabilization: hardware, techniques, and imaging appearances. , 2007, Radiographics : a review publication of the Radiological Society of North America, Inc.

[22]  J. Carey,et al.  Evaluation of Diagnosis Techniques Used for Spinal Injury Related Back Pain , 2011, Pain research and treatment.

[23]  Claire Moore,et al.  Acute versus chronic vertebral compression fractures treated with kyphoplasty: early results. , 2004, The spine journal : official journal of the North American Spine Society.

[24]  P. Matin Bone scintigraphy in the diagnosis and management of traumatic injury. , 1983, Seminars in nuclear medicine.

[25]  C. Claussen,et al.  Evaluation of combined transmission and emission tomography for classification of skeletal lesions. , 2004, AJR. American journal of roentgenology.

[26]  P. Hession,et al.  Imaging of spondylolysis and spondylolisthesis , 2004, European Radiology.

[27]  D. Herbert,et al.  Bone stress: a radionuclide imaging perspective. , 1979, Radiology.

[28]  N. Friederich,et al.  Combined single-photon emission computerized tomography and conventional computerized tomography (SPECT/CT): clinical value for the knee surgeons? , 2010, Knee Surgery, Sports Traumatology, Arthroscopy.

[29]  Joshua A Hirsch,et al.  Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis. , 2003, Radiology.

[30]  G. F. Gates,et al.  Bone SPECT of the back after lumbar surgery. , 1999, Clinical nuclear medicine.

[31]  C. Love,et al.  The evolution of nuclear medicine and the musculoskeletal system. , 2009, Radiologic clinics of North America.

[32]  A. Quigley,et al.  Is hybrid imaging (SPECT/CT) a useful adjunct in the management of suspected facet joints arthropathy? , 2013, International Orthopaedics.

[33]  William Hollingworth,et al.  A randomized trial of vertebroplasty for osteoporotic spinal fractures. , 2009, The New England journal of medicine.

[34]  L. Holder,et al.  Radionuclide bone imaging in the early detection of fractures of the proximal femur (hip): multifactorial analysis. , 1990, Radiology.

[35]  E. Lee,et al.  Role of radionuclide imaging in the orthopedic patient. , 2006, The Orthopedic clinics of North America.

[36]  M. Damgaard,et al.  The Role of Bone SPECT/CT in the Evaluation of Lumbar Spinal Fusion With Metallic Fixation Devices , 2010, Clinical nuclear medicine.

[37]  I. Fogelman,et al.  Scintigraphy of benign bone disease. , 2007, Seminars in musculoskeletal radiology.

[38]  M. Reiser,et al.  Whole-Body Imaging of Bone Marrow , 2009, Seminars in musculoskeletal radiology.

[39]  S. Goldsmith,et al.  Bone SPECT in patients with persistent back pain after lumbar spine surgery. , 1989, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[40]  J. Buscombe,et al.  Single-photon emission computed tomography–computed tomography in imaging infection , 2013, Nuclear medicine communications.

[41]  G. V. von Schulthess,et al.  FDG positron emission tomography for differentiation of degenerative and infectious endplate abnormalities in the lumbar spine detected on MR imaging. , 2002, AJR. American journal of roentgenology.

[42]  R. Buchbinder,et al.  A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. , 2009, The New England journal of medicine.

[43]  J. Urbain,et al.  SPECT/CT imaging of the lumbar spine in chronic low back pain: a case report , 2011, Chiropractic & manual therapies.