Activation centrale à la suite d'une stimulation vagale chronique chez le porc : apports de l'imagerie fonctionnelle

Chronic vagus nerve stimulation (VNS), used to treat refractory epilepsy, has the potential to alter food intake in animals and humans. The aim of our study was to evaluate the impact of VNS on the feeding behaviour of pigs used as a human model, and to investigate the origin of its potential effects. Food intake was significantly decreased after five weeks of chronic VNS. This reduction was not due to stimulation of the vagus efferents as neither gastric compliance nor gastric emptying was altered. VNS triggered a reorganisation of brain activation, probably via subcortical structures involved in the reward mechanism. The activation of the olfactory bulb during VNS is probably one of the mechanisms responsible for the drastic changes in food preference in favour of lipids.

[1]  Olfactory bulb neurons respond to gastric distension , 1985, Brain Research Bulletin.

[2]  M. Wayner,et al.  Olfactory and visceral projections to the nucleus of the solitary tract , 1988, Physiology & Behavior.

[3]  C. Strazielle,et al.  An unexpected role of the cerebellum: Involvement in nutritional organization , 1993, Physiology & Behavior.

[4]  R. McLachlan,et al.  Vagus nerve stimulation for intractable epilepsy: a review. , 1997, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[5]  K. Hveem,et al.  Relation between postprandial satiation and antral area in normal subjects. , 1997, The American journal of clinical nutrition.

[6]  C. Malbert,et al.  Proximal gastric distension modifies ingestion rate in pigs. , 1997, Reproduction, nutrition, development.

[7]  Are fundic receptors sensitive to circumferential wall tension in vivo , 1998 .

[8]  J. Marcilloux,et al.  Stereotaxic atlas of the pig brain , 1999, Brain Research Bulletin.

[9]  J. Malagelada,et al.  Gastric wall tension determines perception of gastric distention. , 1999, Gastroenterology.

[10]  G. Schwartz,et al.  The role of gastrointestinal vagal afferents in the control of food intake: current prospects. , 2000, Nutrition.

[11]  Lennart Thurfjell,et al.  Validation of fully automatic brain SPET to MR co-registration , 2000, European Journal of Nuclear Medicine.

[12]  C. Malbert,et al.  Changes in intragastric meal distribution are better predictors of gastric emptying rate in conscious pigs than are meal viscosity or dietary fibre concentration , 2001, British Journal of Nutrition.

[13]  B. Richelsen,et al.  The obese Göttingen minipig as a model of the metabolic syndrome: dietary effects on obesity, insulin sensitivity, and growth hormone profile. , 2001, Comparative medicine.

[14]  S Minoshima,et al.  Gastric distention correlates with activation of multiple cortical and subcortical regions. , 2001, Gastroenterology.

[15]  C. Malbert,et al.  Role of vagal innervation on intragastric distribution and emptying of liquid and semisolid meals in conscious pigs , 2001, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[16]  G. Królczyk,et al.  Effects of continuous microchip (MC) vagal neuromodulation on gastrointestinal function in rats. , 2001, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[17]  R. Carr,et al.  High‐Fat High‐Energy Feeding Impairs Fasting Glucose and Increases Fasting Insulin Levels in the Göttingen Minipig , 2002, Annals of the New York Academy of Sciences.

[18]  R. Kuzniecky,et al.  Weight loss associated with vagus nerve stimulation , 2002, Neurology.

[19]  R. Watts,et al.  Cerebral Activation during Vagus Nerve Stimulation: A Functional MR Study , 2002, Epilepsia.

[20]  R. Fogel,et al.  The Central Nucleus of the Amygdala Modulates Gut‐Related Neurons in the Dorsal Vagal Complex in Rats , 2003, The Journal of physiology.

[21]  G. Schwartz,et al.  Anterograde Transneuronal Viral Tracing of Central Viscerosensory Pathways in Rats , 2004, The Journal of Neuroscience.

[22]  Jianglin Fan,et al.  A minipig model of high‐fat/high‐sucrose diet‐induced diabetes and atherosclerosis , 2004, International journal of experimental pathology.

[23]  J. Warwick.  Imaging of Brain Function Using SPECT , 2004, Metabolic Brain Disease.

[24]  G. Schwartz.  Biology of eating behavior in obesity. , 2004, Obesity research.

[25]  J. Tack,et al.  Pathophysiology of functional dyspepsia. , 2004, Best practice & research. Clinical gastroenterology.

[26]  E. DeMaria,et al.  Surgical options for obesity. , 2005, Gastroenterology clinics of North America.

[27]  A. Jean,et al.  In vivo neurogenesis in the dorsal vagal complex of the adult rat brainstem , 2005, Neuroscience.

[28]  E. Mun,et al.  Surgical management of morbid obesity. , 2005, Diabetes care.

[29]  K. Smetana,et al.  The Miniature Pig as an Animal Model in Biomedical Research , 2005, Annals of the New York Academy of Sciences.

[30]  Marta Pérez,et al.  Roux-en-Y gastric bypass: major complications , 2007, Abdominal Imaging.

[31]  J. Estany,et al.  Does vagal nerve stimulation affect body composition and metabolism? Experimental study of a new potential technique in bariatric surgery. , 2006, Surgery.

[32]  Capsaicin-sensitive afferent vagal fibers are involved in concurrent taste aversion learning , 2006, Neurobiology of Learning and Memory.

[33]  M. Gagner,et al.  Revisional bariatric surgery for inadequate weight loss , 2007, Obesity surgery.

[34]  A. Ziomber,et al.  Effect of long-term vagal stimulation on food intake and body weight during diet induced obesity in rats. , 2007, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[35]  Y. Cakmak,et al.  The pathways connecting the hippocampal formation, the thalamic reuniens nucleus and the thalamic reticular nucleus in the rat , 2008, Journal of anatomy.

[36]  S. Dietrich,et al.  A novel transcutaneous vagus nerve stimulation leads to brainstem and cerebral activations measured by functional MRI / Funktionelle Magnetresonanztomographie zeigt Aktivierungen des Hirnstamms und weiterer zerebraler Strukturen unter transkutaner Vagusnervstimulation , 2008, Biomedizinische Technik. Biomedical engineering.

[37]  R. Vettor,et al.  Endocannabinoids, Adipose Tissue and Lipid Metabolism , 2008, Journal of neuroendocrinology.

[38]  Safiye Çavdar,et al.  Cerebellar connections: hypothalamus , 2008, The Cerebellum.