Yeast multidrug resistance: The PDR network

This minireview describes a network of genes involved in multiple drug resistance of the yeastS. cerevisiae. The transcription regulators, PDR1, PDR3, PDR7, and PDR9 control the expression of the genePDR5, encoding a membrane protein of the ATP-binding-cassette superfamily and functioning as a drug extrusion pump. Next toPDR5, several other target genes, encoding membrane pumps of the ABC type, such asSNQ2, STE6, PDR10, PDR11, Y0R1, but also other membrane-associated (such asGAS1, D4405) or soluble proteins (such asG3PD), involved or not in multidrug resistance, are found to be controlled by PDR1. On another side, the PDR3 regulator participates with its homolog PDR1 to co- and auto-regulation circuits of yeast multidrug resistance.

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