Effect of maturation and aging on the rate of fast axoplasmic transport in mammalian nerve.

Publisher Summary This chapter discusses the effect of maturation and aging on the rate of fast axoplasmic transport in mammalian nerve. The effect of maturation and aging on the rate of fast axoplasmic transport is studied in the cat and a group of dogs used to augment the age studies. The most significant finding is of a similarity in the rate found over a wide span of age. Both the fast and slow transport systems present within nerve fibers carry materials synthesized in the cell body down inside the axons to maintain their viability, to supply materials to the nerve terminals required for transmission, and trophic materials to the cells with which the nerve terminals synapse or to cells with which these transport systems are in contiguity. A possible, slightly lower rate was seen in the newborn kitten and in some aged animals a somewhat higher rate was encountered. These were too few to be significant and the results further emphasize the regularity of the fast axoplasmic transport mechanism.

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