In Vitro and In Vivo Characterization of Biodegradable Poly(organophosphazenes) for Biomedical Applications

[1]  C. Laurencin,et al.  In vivo biodegradability and biocompatibility evaluation of novel alanine ester based polyphosphazenes in a rat model. , 2006, Journal of biomedical materials research. Part A.

[2]  A. Andrianov,et al.  Degradation of polyaminophosphazenes: effects of hydrolytic environment and polymer processing. , 2006, Biomacromolecules.

[3]  Cato T Laurencin,et al.  Effect of side group chemistry on the properties of biodegradable L-alanine cosubstituted polyphosphazenes. , 2006, Biomacromolecules.

[4]  W. Hennink,et al.  In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[5]  Xiaobin Huang,et al.  Asymmetric penta-armed poly(ε-caprolactone)s with short-chain phosphazene core : synthesis, characterization, and in vitro degradation , 2005 .

[6]  Soo-Chang Song,et al.  Hydrolysis‐improved thermosensitive polyorganophosphazenes with α‐amino‐ω‐methoxy‐poly(ethylene glycol) and amino acid esters as side groups , 2005 .

[7]  A. Andrianov,et al.  Water-soluble biodegradable polyphosphazenes containing N-ethylpyrrolidone groups , 2005 .

[8]  Y. Sohn,et al.  Selective tumor targeting by enhanced permeability and retention effect. Synthesis and antitumor activity of polyphosphazene-platinum (II) conjugates. , 2005, Journal of inorganic biochemistry.

[9]  K. Zhu,et al.  Physicochemical characterization of polymeric micelles constructed from novel amphiphilic polyphosphazene with poly(N-isopropylacrylamide) and ethyl 4-aminobenzoate as side groups. , 2005, Colloids and surfaces. B, Biointerfaces.

[10]  H. Allcock,et al.  Environmentally responsive micelles from polystyrene–poly[bis(potassium carboxylatophenoxy)phosphazene] block copolymers , 2005 .

[11]  R. Gaumond,et al.  Patterning poly(organophosphazenes) for selective cell adhesion applications. , 2005, Biomacromolecules.

[12]  D. Crommelin,et al.  An NLS peptide covalently linked to linear DNA does not enhance transfection efficiency of cationic polymer based gene delivery systems , 2005, The journal of gene medicine.

[13]  Renato Scienza,et al.  In vitro culture of rat neuromicrovascular endothelial cells on polymeric scaffolds. , 2004, Journal of biomedical materials research. Part A.

[14]  Cato T Laurencin,et al.  Fabrication and optimization of methylphenoxy substituted polyphosphazene nanofibers for biomedical applications. , 2004, Biomacromolecules.

[15]  A. Andrianov,et al.  Synthesis and biologically relevant properties of polyphosphazene polyacids. , 2004, Biomacromolecules.

[16]  H. Allcock,et al.  Synthesis and Micellar Behavior of Amphiphilic Polystyrene-Poly[bis(methoxyethoxyethoxy)phosphazene] Block Copolymers , 2004 .

[17]  Buddy D Ratner,et al.  Biomaterials: where we have been and where we are going. , 2004, Annual review of biomedical engineering.

[18]  B. Lee,et al.  Synthesis and characterization of biodegradable Thermosensitive poly(organophosphazene) gels , 2004 .

[19]  M. Gleria,et al.  Applicative aspects of poly(organophosphazenes) , 2004 .

[20]  Xiaozhen Tang,et al.  Novel micro-crosslinked poly(organophosphazenes) with improved mechanical properties and controllable degradation rate as potential biodegradable matrix. , 2004, Biomaterials.

[21]  A M Ambrosio,et al.  Novel polyphosphazene-hydroxyapatite composites as biomaterials. , 2003, IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society.

[22]  H. Allcock,et al.  Tyrosine-bearing polyphosphazenes. , 2003, Biomacromolecules.

[23]  R. Adhikari,et al.  Biodegradable synthetic polymers for tissue engineering. , 2003, European cells & materials.

[24]  C. van Nostrum,et al.  Water-soluble biodegradable cationic polyphosphazenes for gene delivery. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[25]  C T Laurencin,et al.  Biodegradable polyphosphazenes for drug delivery applications. , 2003, Advanced drug delivery reviews.

[26]  H. Allcock,et al.  A Covalently Interconnected Phosphazene–Silicate Hybrid Network: Synthesis, Characterization, and Hydrogel Diffusion‐Related Application , 2003 .

[27]  Sang Mi Park,et al.  Thermosensitive Behavior of Poly(ethylene oxide)-Poly[bis(methoxyethoxyethoxy)- phosphazene] Block Copolymers , 2003 .

[28]  H. Allcock,et al.  Amphiphilic Poly[bis(trifluoroethoxy)phosphazene]−Poly(ethylene oxide) Block Copolymers: Synthesis and Micellar Characteristics , 2002 .

[29]  H. Allcock,et al.  Synthesis and self-association behavior of biodegradable amphiphilic poly[bis(ethyl glycinat-N-yl)phosphazene]- poly(ethylene oxide) block copolymers. , 2002, Biomacromolecules.

[30]  M. Gümüşderelioğlu,et al.  Synthesis, characterization, in vitro degradation and cytotoxicity of poly[bis(ethyl 4-aminobutyro)phosphazene] , 2002 .

[31]  B. Lee,et al.  Thermosensitive and hydrolysis‐sensitive poly(organophosphazenes) , 2002 .

[32]  L. Qiu.  In vitro and in vivo degradation study on novel blends composed of polyphosphazene and polyester or polyanhydride , 2002 .

[33]  D. Katti,et al.  Degradable polyphosphazene/poly(α-hydroxyester) blends: degradation studies , 2002 .

[34]  D. Mooney,et al.  Hydrogels for tissue engineering. , 2001, Chemical reviews.

[35]  K. Zhu,et al.  Novel blends of poly[bis(glycine ethyl ester) phosphazene] and polyesters or polyanhydrides: compatibility and degradation characteristics in vitro , 2000 .

[36]  K. Zhu,et al.  Novel biodegradable polyphosphazenes containing glycine ethyl ester and benzyl ester of amino acethydroxamic acid as cosubstituents : Syntheses, characterization, and degradation properties , 2000 .

[37]  Sang Beom Lee,et al.  A New Class of Biodegradable Thermosensitive Polymers. 2. Hydrolytic Properties and Salt Effect on the Lower Critical Solution Temperature of Poly(organophosphazenes) with Methoxypoly(ethylene glycol) and Amino Acid Esters as Side Groups , 1999 .

[38]  Sang Beom Lee,et al.  A New Class of Biodegradable Thermosensitive Polymers. I. Synthesis and Characterization of Poly(organophosphazenes) with Methoxy-Poly(ethylene glycol) and Amino Acid Esters as Side Groups , 1999 .

[39]  O. Böstman,et al.  Late Foreign-Body Reaction to an Intraosseous Bioabsorbable Polylactic Acid Screw. A Case Report* , 1998, The Journal of bone and joint surgery. American volume.

[40]  O. Böstman,et al.  Osteoarthritis of the ankle after foreign-body reaction to absorbable pins and screws: a three- to nine-year follow-up study. , 1998, The Journal of bone and joint surgery. British volume.

[41]  E. Schacht,et al.  Biodegradable Poly[(Amino Acid Ester)phosphazenes] for Biomedical Applications , 1998 .

[42]  H R Allcock,et al.  Novel polyphosphazene/poly(lactide-co-glycolide) blends: miscibility and degradation studies. , 1997, Biomaterials.

[43]  E. Schacht,et al.  Biodegradable polyphosphazenes for drug delivery , 1997 .

[44]  P. Caliceti,et al.  Peripheral Nerve Reconstruction with Bioabsorbable Polyphosphazene Conduits , 1997 .

[45]  E. Schacht,et al.  Biomedical applications of degradable polyphosphazenes. , 1996, Biotechnology and bioengineering.

[46]  C. Laurencin,et al.  Controlled macromolecule release from poly(phosphazene) matrices , 1996 .

[47]  P. Caliceti,et al.  Anti‐inflammatory Activity of Polyphosphazene‐based Naproxen Slow‐release Systems , 1996, The Journal of pharmacy and pharmacology.

[48]  H. Allcock,et al.  Lower Critical Solubility Temperature Study of Alkyl Ether Based Polyphosphazenes , 1996 .

[49]  H R Allcock,et al.  A highly porous 3-dimensional polyphosphazene polymer matrix for skeletal tissue regeneration. , 1996, Journal of biomedical materials research.

[50]  R. Langer,et al.  Hydrolytic degradation of ionically cross‐linked polyphosphazene microspheres , 1994 .

[51]  Harry R. Allcock,et al.  Poly[(amino acid ester)phosphazenes]: Synthesis, Crystallinity, and Hydrolytic Sensitivity in Solution and the Solid State , 1994 .

[52]  H. Allcock,et al.  Poly[(amino acid ester)phosphazenes] as substrates for the controlled release of small molecules. , 1994, Biomaterials.

[53]  A. U. Daniels,et al.  Six bioabsorbable polymers: in vitro acute toxicity of accumulated degradation products. , 1994, Journal of applied biomaterials : an official journal of the Society for Biomaterials.

[54]  Smadar Cohen,et al.  Controlled release using ionotropic polyphosphazene hydrogels , 1993 .

[55]  H R Allcock,et al.  Use of polyphosphazenes for skeletal tissue regeneration. , 1993, Journal of biomedical materials research.

[56]  Etienne Schacht,et al.  Degradable polyphosphazenes for biomedical applications , 1993 .

[57]  C. Laurencin,et al.  Osteoblast culture on bioerodible polymers: studies of initial cell adhesion and spread , 1992 .

[58]  M. Turner,et al.  Poly(organophosphazenes) with poly(alkyl ether) side groups: a study of their water solubility and the swelling characteristics of their hydrogels , 1992 .

[59]  H. Allcock,et al.  Thin-layer grafts of poly[bis((methoxyethoxy)ethoxy)phosphazene] on organic polymer surfaces , 1992 .

[60]  P. Caliceti,et al.  Biocompatible polyphosphazenes by radiation-induced graft copolymerization and heparinization. , 1991, Biomaterials.

[61]  Smadar Cohen,et al.  Ionically crosslinkable polyphosphazene: a novel polymer for microencapsulation , 1990 .

[62]  H. Allcock,et al.  Glyceryl polyphosphazenes: synthesis, properties, and hydrolysis , 1988 .

[63]  K. Groot,et al.  Development of implantable antitumor devices based on polyphosphazenes , 1988 .

[64]  H R Allcock,et al.  Controlled release using a new bioerodible polyphosphazene matrix system. , 1987, Journal of biomedical materials research.

[65]  H. Allcock,et al.  Phosphazene High Polymers with Steroidal Side Groups , 1980 .

[66]  H. Allcock,et al.  Phosphorus-nitrogen compounds. 30. Synthesis of platinum derivatives of polymeric and cyclic phosphazenes , 1977 .

[67]  H. Allcock.  Recent advances in phosphazene (phosphonitrilic) chemistry , 1972 .

[68]  C. Laurencin,et al.  Synthesis, characterization, and osteocompatibility evaluation of novel alanine-based polyphosphazenes. , 2006, Journal of biomedical materials research. Part A.

[69]  Alexander K Andrianov,et al.  Synthesis, properties, and biological activity of poly[di(sodium carboxylatoethylphenoxy)phosphazene]. , 2006, Biomacromolecules.

[70]  C. Laurencin,et al.  Low temperature formation of hydroxyapatite-poly(alkyl oxybenzoate)phosphazene composites for biomedical applications. , 2005, Biomaterials.

[71]  D. Bruley,et al.  Polyphosphates and other phosphorus-containing polymers for drug delivery applications. , 2003, Critical reviews in therapeutic drug carrier systems.

[72]  P. Caliceti,et al.  Polyphosphazene membranes and microspheres in periodontal diseases and implant surgery. , 1999, Biomaterials.

[73]  C. Laurencin,et al.  In vitro release of colchicine using poly(phosphazenes): the development of delivery systems for musculoskeletal use. , 1998, Pharmaceutical development and technology.

[74]  Anthony Atala,et al.  Synthetic Biodegradable Polymer Scaffolds , 1997, Birkhäuser Boston.

[75]  H. Allcock,et al.  Synthesis and characterization of pH-sensitive poly(organophosphazene) hydrogels. , 1996, Biomaterials.

[76]  P. Caliceti,et al.  Peripheral nerve repair using a poly(organo)phosphazene tubular prosthesis. , 1995, Biomaterials.

[77]  H R Allcock,et al.  Design of synthetic polymeric structures for cell transplantation and tissue engineering. , 1993, Clinical materials.

[78]  E. Schacht,et al.  Biodegradable polymers. II. Degradation characteristics of hydrolysis-sensitive poly[(organo)phosphazenes]. , 1992, Biomaterials.

[79]  E. Schacht,et al.  Biodegradable polymers. I. Synthesis of hydrolysis-sensitive poly[(organo)phosphazenes]. , 1992, Biomaterials.

[80]  H. Allcock,et al.  Antibacterial activity and mutagenicity studies of water-soluble phosphazene high polymers. , 1992, Biomaterials.

[81]  D. Williams,et al.  Mechanisms of biodegradation of implantable polymers. , 1992, Clinical materials.

[82]  H. Allcock,et al.  Polyphosphazenes with glucosyl and methylamino, trifluoroethoxy, phenoxy, or (methoxyethoxy)ethoxy side groups , 1991 .

[83]  J. Mcgrath,et al.  Synthesis and characterization of perfectly alternating polyorganosiloxane—Polyarylester and —Poly(aryl formal) block copolymers , 1990 .

[84]  Jindřich Kopeček,et al.  Biodegradation of biomedical polymers , 1983 .

[85]  D. P. Mack,et al.  Synthesis of Poly[(amino acid alkyl ester)phosphazenes] , 1977 .

[86]  Harry R. Allcock,et al.  Synthesis of High Polymeric Alkoxy- and Aryloxyphosphonitriles , 1965 .