论文信息 - Relationship between the progesterone, androgen, and glucocorticoid receptor and response rate to endocrine therapy in metastatic breast cancer.

Relationship between the progesterone, androgen, and glucocorticoid receptor and response rate to endocrine therapy in metastatic breast cancer.

85 patients with metastatic or surgically unrecsectable primary breast cancer who had had 1 or more steroid hormone receptor assays performed immediately before the institution of endocrine therapy were studied retrospectively to determine any influence of steroid hormone receptors on response rate to endocrine therapy. Included in addition to effects of estrogen receptor (ER) status are the effects of androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor (GR) on therapy perfornamce. Of 18 patients whose tumor contained PR, 11 responded to endocrine therapy, compared with 8 of 26 patients with low or absent PR. PR increased the predictive index of the ER in an group of patients who had received no prior therapy, but it did not help in patients who had received prior endocrine therapy. 0 of 4 patients whose tumors were ER negative but PR positive responded to endocrine therapy. Present trends suggest a possible association between AR and GR and response to endocrine therapy. A cut-off value of 10 fmol/mg of cytoplasmic protein was needed to make these trends apparent. The distributions of AR and GR values for responders and nonresponders were not significantly different. Knowledge of AR status does not increase the protective index in ER-positive or ER-negative tumors. GR positivity may increase the predictive index in ER-positive tumors, but not in ER-negative ones.

[1] R. Simon,et al. Association between steroid hormone receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. , 1978, Cancer treatment reports.

[2] W. McGuire,et al. Current status of estrogen and progesterone receptors in breast cancer , 1977, Cancer.

[3] M. Lippman,et al. A demonstration of androgen and estrogen receptors in a human breast cancer using a new protamine sulfate assay , 1976, Cancer.

[4] J. Persijn,et al. Oestrogen and androgen receptors in breast cancer and response to endocrine therapy. , 1975, British medical journal.

[5] M. Lippman,et al. Human breast cancer responsive to androgen in long term tissue culture , 1975, Nature.

[6] L. Görlich,et al. Dihydrotestosterone receptor in human mammary cancer. , 1973, Acta endocrinologica. Supplementum.

[7] A. Segaloff,et al. Androgenic therapy for advanced breast cancer in women. A report of the cooperative breast cancer group. , 1973, JAMA.

[8] R. Forthofer,et al. Rank Correlation Methods , 1981 .

[9] H. van Gilse,et al. Demonstration of glucocorticoid receptors in human mammary carcinomas. , 1977, Hormone research.

[10] M. Lippman,et al. A simple computer program for quantitation and Scatchard analysis of steroid receptor proteins. , 1977, Journal of steroid biochemistry.