Expression of protease activated receptor‐2 (PAR‐2) in gastric cancer

Recently, the four‐kind cloning of the protease‐activated receptor (PAR) had been carried out. PAR‐2 is activated by trypsin and it is supposed that PAR‐2 participated in proliferation of the endothelial cell or in neovascularization. We considered whether the expression of PAR‐2 has relevance to progression in gastric cancer.

[1]  K. Tsuchihara,et al.  Prognostic relevance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors PAI-1 and PAI-2 in gastric cancer , 1996, Virchows Archiv.

[2]  M. Grégoire,et al.  The role of fibroblasts in tumor behavior , 1995, Cancer and Metastasis Reviews.

[3]  H. Kitagawa,et al.  Protease-activated receptor-2 expression and the role of trypsin in cell proliferation in human pancreatic cancers. , 2003, International journal of oncology.

[4]  T. Goi,et al.  Expression of CD44v6 in advanced gastric cancer and its relationship to hematogenous metastasis and long‐term prognosis , 2002, Journal of surgical oncology.

[5]  M. Laburthe,et al.  Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2 , 2001, British Journal of Cancer.

[6]  M. D'Andrea,et al.  Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues. , 2001, The American journal of pathology.

[7]  L. Brass,et al.  Protease activated receptors: theme and variations , 2001, Oncogene.

[8]  N. Koshikawa,et al.  Trypsin Stimulates Integrin α5β1-dependent Adhesion to Fibronectin and Proliferation of Human Gastric Carcinoma Cells through Activation of Proteinase-activated Receptor-2* , 2000, The Journal of Biological Chemistry.

[9]  Y. Miyagi,et al.  Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture. , 1999, Journal of biochemistry.

[10]  K. Hirose,et al.  Surgical results of pancreaticoduodenectomy for carcinoma of the distal third of the stomach. , 1999, International surgery.

[11]  Y. Miyagi,et al.  Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse. , 1998, The American journal of pathology.

[12]  M. Macey,et al.  Immunolocalization of protease‐activated receptor‐2 in skin: receptor activation stimulates interleukin‐8 secretion by keratinocytes in vitro , 1998, Immunology.

[13]  M. Steinhoff,et al.  Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. , 1998, American journal of physiology. Cell physiology.

[14]  T. Terada,et al.  Inhibitory effect of a serine protease inhibitor, FOY-305 on the invasion and metastasis of human pancreatic cancers. , 1997, International journal of oncology.

[15]  Y. Miyagi,et al.  Expression of trypsin in vascular endothelial cells , 1997, FEBS letters.

[16]  Hiroshi Yamamoto,et al.  Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer. , 1996, British Journal of Cancer.

[17]  S. Coughlin,et al.  Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. , 1996, The Biochemical journal.

[18]  T. Urano,et al.  Expression of CD44 Variant Exons 8‐10 in Gastric Cancer , 1995, Japanese journal of cancer research : Gann.

[19]  Y. Miyagi,et al.  Trypsinogen expression in human ovarian carcinomas , 1995, International journal of cancer.

[20]  B. Strömbeck,et al.  Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. , 1995, European journal of biochemistry.

[21]  Y. Okada,et al.  Expression of membrane-type matrix metalloproteinase in human gastric carcinomas. , 1995, Cancer research.

[22]  Y. Nagashima,et al.  Identification of one- and two-chain forms of trypsinogen 1 produced by a human gastric adenocarcinoma cell line. , 1994, The Biochemical journal.

[23]  C. Wahlestedt,et al.  Molecular cloning of a potential proteinase activated receptor. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[24]  N. Koshikawa,et al.  Multiple secretion of matrix serine proteinases by human gastric carcinoma cell lines. , 1992, Cancer research.

[25]  A. Ristimäki,et al.  Tumor-associated trypsin participates in cancer cell-mediated degradation of extracellular matrix. , 1991, Cancer research.

[26]  O. Itkonen,et al.  Human colon carcinoma, fibrosarcoma and leukemia cell lines produce tumor‐associated trypsinogen , 1991, International journal of cancer.

[27]  L. Liotta,et al.  Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation , 1991, Cell.

[28]  K. Suzuki,et al.  Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). , 1990, Biochemistry.

[29]  R. O’meara Coagulative properties of cancers , 1958, Irish Journal of Medical Science.