Topical aminoglycosides in the management of active mucosal chronic suppurative otitis media

Abstract Debate has currently re-emerged following a renewed warning issued from the Committee on the Safety of Medicines (CSM) regarding the relative risk of ototoxicity from the use of aminoglycoside-containing drops in patients with tympanic membrane perforations. We present the findings of a survey of ENT consultants, questioning their views and current practice, and we add to the debate by means of a review and discussion of the literature.

[1]  J. Rutka,et al.  Ototoxicity and topical eardrops. , 1998, Clinical otolaryngology and allied sciences.

[2]  R. Jones,et al.  Ofloxacin otic solution for treatment of otitis externa in children and adults. , 1997, Archives of otolaryngology--head & neck surgery.

[3]  D. Lappin,et al.  Systemic absorption of gentamicin ear drops , 1997, The Journal of Laryngology & Otology.

[4]  Y. Sumitsawan,et al.  Ofloxacin otic solution as treatment of chronic suppurative otitis media and diffuse bacterial otitis externa. , 1995, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[5]  W. Wei,et al.  Bacteriology of chronic suppurative otitis media: ofloxacin susceptibility. , 1995, The Journal of otolaryngology.

[6]  Michael J. Olds,et al.  Advances in Oto-Rhino-Laryngology , 1993 .

[7]  B Black,et al.  Chronic suppurative otitis media. , 1991, Australian family physician.

[8]  R. Dagan,et al.  Medical management of chronic suppurative otitis media without cholesteatoma in children. , 1990, The Journal of pediatrics.

[9]  J. Ben David,et al.  Ototoxicity of ear drops in patients suffering from chronic otitis media , 1989, The Journal of Laryngology & Otology.

[10]  S. Gatehouse,et al.  Medical management of active chronic otitis media: A controlled study , 1988, The Journal of Laryngology & Otology.

[11]  Y Nomura,et al.  Otological significance of the round window. , 1984, Advances in oto-rhino-laryngology.

[12]  C. G. Wright,et al.  Tympanostomy tubes and otic drops , 1983, The Laryngoscope.

[13]  G. Bessard,et al.  [Risk of deafness following ototopical administration of aminoglycoside antibiotic (author's transl)]. , 1980, Therapie.

[14]  C. Brooks,et al.  The Effect of Gentamycin Ear Drops on the Cochlea , 1975 .

[15]  Thomas J. Fria,et al.  Chronic otitis media as a cause of sensorineural hearing loss. , 1973, Archives of otolaryngology.

[16]  M. Oda,et al.  Pathology of Sensorineural Hearing Loss in Otitis Media , 1972, The Annals of otology, rhinology, and laryngology.

[17]  M. Paparella,et al.  Fine Structure of the round Window Membrane , 1971, The Annals of otology, rhinology, and laryngology.

[18]  M. Paparella,et al.  Sensori-neural hearing loss in chronic otitis media and mastoiditis. , 1970, Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology.

[19]  Deafness after topical neomycin. , 1969, British medical journal.

[20]  L. Voldřich.  The kinetics of streptomycin, kanamycin and neomycin in the inner ear. , 1965, Acta oto-laryngologica.

[21]  J. Hůlka.  BONE CONDUCTION CHANGES IN ACUTE OTITIS MEDIA , 1941 .