Cell Signaling : Proteins , Pathways and Mechanisms Identification of an RNA-binding protein that is phosphorylated by PTH and potentially mediates PTH-induced destabilization of Npt 2 a mRNA

Rebecca D. Murray, Michael L. Merchant, Ericka Hardin, Barbara Clark, Syed J. Khundmiri, and Eleanor D. Lederer Robley Rex Veterans Affairs Medical Center, Louisville, Kentucky; Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky; Department of Medicine/Kidney Disease Program, University of Louisville, Louisville, Kentucky; Western Kentucky University, Bowling Green, Kentucky; and Department of Biochemistry, University of Louisville, Louisville, Kentucky

[1]  J. Malter,et al.  Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1 , 2015, Biomolecules.

[2]  María Martín,et al.  Activities at the Universal Protein Resource (UniProt) , 2013, Nucleic Acids Res..

[3]  E. Traboulsi,et al.  Autosomal Dominant Retinitis Pigmentosa Secondary to Pre-mRNA Splicing-Factor Gene PRPF31 (RP11): Review of Disease Mechanism and Report of a Family with a Novel 3-Base Pair Insertion , 2013, Ophthalmic genetics.

[4]  Drena Dobbs,et al.  Computational Tools for Investigating RNA-Protein Interaction Partners , 2013 .

[5]  A. Ramos,et al.  Functional and molecular insights into KSRP function in mRNA decay. , 2013, Biochimica et biophysica acta.

[6]  G. M. Wilson,et al.  Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation. , 2013, Biochimica et biophysica acta.

[7]  Robert H Singer,et al.  mRNA on the Move: The Road to Its Biological Destiny* , 2013, The Journal of Biological Chemistry.

[8]  S. Khundmiri,et al.  Parathyroid hormone (PTH) decreases sodium-phosphate cotransporter type IIa (NpT2a) mRNA stability. , 2013, American journal of physiology. Renal physiology.

[9]  D. Parmeggiani,et al.  Long-term outcomes following "presumed" total parathyroidectomy for secondary hyperparathyroidism of chronic kidney disease. , 2012, Il Giornale di chirurgia.

[10]  F. Pociot,et al.  TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC. , 2012, Journal of proteomics.

[11]  Vasant Honavar,et al.  Predicting RNA-Protein Interactions Using Only Sequence Information , 2011, BMC Bioinformatics.

[12]  P. Stadler,et al.  ViennaRNA Package 2.0 , 2011, Algorithms for Molecular Biology : AMB.

[13]  Xiongbin Lu,et al.  The ATM kinase induces microRNA biogenesis in the DNA damage response. , 2011, Molecular cell.

[14]  H. Jüppner,et al.  Acute Down-regulation of Sodium-dependent Phosphate Transporter NPT2a Involves Predominantly the cAMP/PKA Pathway as Revealed by Signaling-selective Parathyroid Hormone Analogs , 2010, The Journal of Biological Chemistry.

[15]  A. Jacobson,et al.  RNA decay modulates gene expression and controls its fidelity , 2010, Wiley interdisciplinary reviews. RNA.

[16]  Kate B. Cook,et al.  RBPDB: a database of RNA-binding specificities , 2010, Nucleic Acids Res..

[17]  T. Uchida,et al.  The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism. , 2009, The Journal of clinical investigation.

[18]  A. Riccio,et al.  To localize or not to localize: mRNA fate is in 3'UTR ends. , 2009, Trends in cell biology.

[19]  M. Rosenfeld,et al.  The RNA-binding Protein KSRP Promotes the Biogenesis of a Subset of miRNAs , 2016 .

[20]  Geoff Kelly,et al.  Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding , 2009, Nature Structural &Molecular Biology.

[21]  Brad T. Sherman,et al.  Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.

[22]  I. Ben-Dov,et al.  The mRNA decay promoting factor K‐homology splicing regulator protein post‐transcriptionally determines parathyroid hormone mRNA levels , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  T. Glisovic,et al.  RNA‐binding proteins and post‐transcriptional gene regulation , 2008, FEBS letters.

[24]  Ronny Lorenz,et al.  The Vienna RNA Websuite , 2008, Nucleic Acids Res..

[25]  H. Murer,et al.  Proximal tubular handling of phosphate: A molecular perspective. , 2006, Kidney international.

[26]  J. Kappes,et al.  Tethering KSRP, a Decay-Promoting AU-Rich Element-Binding Protein, to mRNAs Elicits mRNA Decay , 2006, Molecular and Cellular Biology.

[27]  N. Déliot,et al.  NaPi‐IIa and interacting partners , 2005, The Journal of physiology.

[28]  H. Tenenhouse Regulation of phosphorus homeostasis by the type iia na/phosphate cotransporter. , 2005, Annual review of nutrition.

[29]  C. Wagner,et al.  Novel aspects in regulated expression of the renal type IIa Na/Pi-cotransporter. , 2004, Kidney international. Supplement.

[30]  M. Karin,et al.  A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. , 2004, Molecular cell.

[31]  G. Segre,et al.  Na+/H+ exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cells. , 2003, Molecular endocrinology.

[32]  J. Silver,et al.  Characterization of cis-acting element in renal NaPi-2 cotransporter mRNA that determines mRNA stability. , 2003, American journal of physiology. Renal physiology.

[33]  G. Orphanides,et al.  A Unified Theory of Gene Expression , 2002, Cell.

[34]  J. Noel,et al.  Critical Role of WW Domain Phosphorylation in Regulating Phosphoserine Binding Activity and Pin1 Function* , 2002, The Journal of Biological Chemistry.

[35]  M. Mann,et al.  AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs , 2001, Cell.

[36]  H. Murer,et al.  Proximal tubular phosphate reabsorption: molecular mechanisms. , 2000, Physiological reviews.

[37]  J. Silver,et al.  Protein-RNA Interactions Determine the Stability of the Renal NaPi-2 Cotransporter mRNA and Its Translation in Hypophosphatemic Rats* , 1999, The Journal of Biological Chemistry.

[38]  N. Amizuka,et al.  Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[39]  Raue Increased incidence of cardiovascular diseases in primary hyperparathyroidism — a cause for more aggressive treatment? , 1998, European journal of clinical investigation.

[40]  Odén,et al.  Increased risk of death from primary hyperparathyroidism — an update , 1998, European journal of clinical investigation.

[41]  E. Lederer,et al.  Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[42]  A. Shyu,et al.  Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU-rich elements , 1996, Molecular and cellular biology.

[43]  C. Y. Chen,et al.  AU-rich elements: characterization and importance in mRNA degradation. , 1995, Trends in biochemical sciences.

[44]  S. Eber,et al.  Regulation of sodium-dependent phosphate transport by parathyroid hormone in opossum kidney cells: adenosine 3',5'-monophosphate-dependent and -independent mechanisms. , 1988, Endocrinology.

[45]  A. Haramati,et al.  Tubular capacity of phosphate transport in phosphate-deprived rats: effects of nicotinamide and PTH. , 1983, The American journal of physiology.

[46]  A. Ramos,et al.  KSRP, many functions for a single protein. , 2011, Frontiers in bioscience.

[47]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[48]  N. Sawada,et al.  The regulation and function of phosphate in the human body , 2004, BioFactors.