Quantitative near‐infrared spectroscopy discriminates between mitochondrial myopathies and normal muscle

Five patients with chronic progressive external ophthalmoplegia (CPEO) and 27 healthy controls were examined by near‐infrared spectroscopy (NIRS) for the noninvasive and direct quantitative measurement of muscle oxygen consumption and forearm blood flow. NIRS measurements were obtained in rest and during static isometric handgrip exercise at 10% of the maximum voluntary contraction (MVC) force. A significantly decreased oxygen consumption at rest as well as during exercise was found in patients with CPEO. Our results suggest that NIRS is able to discriminate between CPEO patients and healthy controls, which makes NIRS a valuable tool in the diagnostic workup of patients suspected to have a mitochondrial myopathy.

[1]  P. Matthews,et al.  Effects of aerobic training in patients with mitochondrial myopathies , 1998, Neurology.

[2]  Z. Argov.  Functional Evaluation Techniques in Mitochondrial Disorders , 1998, European Neurology.

[3]  Y. Matsuo,et al.  Measurement of tissue oxygen consumption in patients with mitochondrial myopathy by noninvasive tissue oximetry , 1997, Neurology.

[4]  T Binzoni,et al.  Oxidative metabolism in muscle. , 1997, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[5]  D. Arnold,et al.  Abnormal oxidative metabolism in exercise in exercise intolerance of undetermined origin , 1997, Neuromuscular Disorders.

[6]  W. Bank,et al.  An oxidative defect in metabolic myopathies: Diagnosis by noninvasive tissue oximetry , 1994, Annals of neurology.

[7]  R. Haller.  Oxygen Utilization and delivery in metabolic my opathies , 1994, Annals of neurology.

[8]  H. Schouten,et al.  Interobserver agreement for the assessment of handicap in stroke patients. , 1988, Stroke.

[9]  Ron A. Wevers,et al.  Validation of measurement protocols to assess oxygen consumption and blood flow in the human forearm by near-infrared spectroscopy , 1998, European Conference on Biomedical Optics.

[10]  Willy N. Colier,et al.  New and highly sensitive continuous-wave near-infrared spectrophotometer with multiple detectors , 1998, European Conference on Biomedical Optics.

[11]  Emery.  Diagnostic Criteria for Neuromuscular Disorders , 1997 .