Homeostatic control of mitotic arrest.

[1]  P. Sorger,et al.  p31comet acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment , 2011, Molecular biology of the cell.

[2]  Hongtao Yu,et al.  Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31comet , 2011, Molecular biology of the cell.

[3]  J. Pines,et al.  APC15 drives the turnover of MCC-Cdc20 to make the Spindle Assembly Checkpoint responsive to kinetochore attachment , 2011, Nature Cell Biology.

[4]  E. Nigg,et al.  Probing the in vivo function of Mad1:C‐Mad2 in the spindle assembly checkpoint , 2011, The EMBO journal.

[5]  Hui-Yan Li,et al.  Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability , 2011, Nature Cell Biology.

[6]  Adam R. Johnson,et al.  Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 , 2011, Nature.

[7]  R. Poon,et al.  Orderly Inactivation of the Key Checkpoint Protein Mitotic Arrest Deficient 2 (MAD2) during Mitotic Progression* , 2011, The Journal of Biological Chemistry.

[8]  T. Kapoor,et al.  Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation , 2011, Nature Cell Biology.

[9]  Avram Hershko,et al.  p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process , 2011, Proceedings of the National Academy of Sciences.

[10]  M. Malumbres,et al.  Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase. , 2010, Cancer cell.

[11]  S. Gygi,et al.  SCFFbw7 Regulates Cellular Apoptosis By Targeting Mcl-1 for Ubiquitination and Destruction , 2010, Nature.

[12]  P. Gönczy,et al.  Mutual Antagonism Between the Anaphase Promoting Complex and the Spindle Assembly Checkpoint Contributes to Mitotic Timing in Caenorhabditis elegans , 2010, Genetics.

[13]  D. Oh,et al.  Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. , 2010, Cancer cell.

[14]  E. Lam,et al.  Sustained Spindle-Assembly Checkpoint Response Requires De Novo Transcription and Translation of Cyclin B1 , 2010, PloS one.

[15]  P. Clarke,et al.  Phosphorylation of Mcl‐1 by CDK1–cyclin B1 initiates its Cdc20‐dependent destruction during mitotic arrest , 2010, The EMBO journal.

[16]  Stephen S. Taylor,et al.  Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex , 2010, The Journal of cell biology.

[17]  A. Hershko,et al.  ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint , 2010, Proceedings of the National Academy of Sciences.

[18]  D. Grieco,et al.  Requirement for proteolysis in spindle assembly checkpoint silencing , 2010, Cell cycle.

[19]  M. Kirschner,et al.  UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex , 2010, Proceedings of the National Academy of Sciences.

[20]  C. Rieder,et al.  The nature of cell-cycle checkpoints: facts and fallacies , 2009, Journal of biology.

[21]  Gary H Karpen,et al.  Identification of a physiological E2 module for the human anaphase-promoting complex , 2009, Proceedings of the National Academy of Sciences.

[22]  T. Mitchison,et al.  Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. , 2009, Cancer cell.

[23]  Paul Russell,et al.  UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit , 2009, Nature Cell Biology.

[24]  J. R. Daum,et al.  Ska3 Is Required for Spindle Checkpoint Silencing and the Maintenance of Chromosome Cohesion in Mitosis , 2009, Current Biology.

[25]  A. Musacchio,et al.  The life and miracles of kinetochores , 2009, The EMBO journal.

[26]  Karl Mechtler,et al.  Structure of the Anaphase-Promoting Complex/Cyclosome Interacting with a Mitotic Checkpoint Complex , 2009, Science.

[27]  R. Wäsch,et al.  Strong inducible knockdown of APC/CCdc20 does not cause mitotic arrest in human somatic cells , 2009, Cell cycle.

[28]  D. Cleveland,et al.  Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. , 2009, Developmental cell.

[29]  Andrea Ciliberto,et al.  The Influence of Catalysis on Mad2 Activation Dynamics , 2009, PLoS biology.

[30]  M. Pagano,et al.  APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation , 2009, Cell cycle.

[31]  Jeremy Minshull,et al.  The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction , 2008, Nature Cell Biology.

[32]  B. Pan,et al.  The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC. , 2008, Molecular cell.

[33]  Stephen S. Taylor,et al.  Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. , 2008, Cancer cell.

[34]  A. Hershko,et al.  Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20 , 2008, Proceedings of the National Academy of Sciences.

[35]  R. Wolthuis,et al.  Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. , 2008, Molecular cell.

[36]  J. Rizo,et al.  p31comet Blocks Mad2 Activation through Structural Mimicry , 2007, Cell.

[37]  E. Salmon,et al.  The spindle-assembly checkpoint in space and time , 2007, Nature Reviews Molecular Cell Biology.

[38]  M. Kirschner,et al.  Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation , 2007, Nature.

[39]  Viji M. Draviam,et al.  Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities , 2007, Nature.

[40]  K. Hardwick,et al.  Mad3 KEN Boxes Mediate both Cdc20 and Mad3 Turnover, and Are Critical for the Spindle Checkpoint , 2007, PloS one.

[41]  A. Hershko,et al.  Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint , 2007, Proceedings of the National Academy of Sciences.

[42]  M. Solomon,et al.  Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint. , 2007, Genes & development.

[43]  Conly L. Rieder,et al.  Mitotic Checkpoint Slippage in Humans Occurs via Cyclin B Destruction in the Presence of an Active Checkpoint , 2006, Current Biology.

[44]  Andrew M. Fry,et al.  Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C , 2006, Nature Cell Biology.

[45]  L. Nezi,et al.  Determinants of conformational dimerization of Mad2 and its inhibition by p31comet , 2006, The EMBO journal.

[46]  Andrea Musacchio,et al.  The Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly Checkpoint , 2005, Current Biology.

[47]  Helder Maiato,et al.  Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. , 2004, Developmental cell.

[48]  J. Rizo,et al.  Conformation‐specific binding of p31comet antagonizes the function of Mad2 in the spindle checkpoint , 2004, The EMBO journal.

[49]  Rey-Huei Chen,et al.  Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. , 2004, Genes & development.

[50]  W. Earnshaw,et al.  Sgt1 is required for human kinetochore assembly , 2004, EMBO reports.

[51]  J. Rizo,et al.  The Mad2 spindle checkpoint protein has two distinct natively folded states , 2004, Nature Structural &Molecular Biology.

[52]  Tomohiro Matsumoto,et al.  Identification of a MAD2‐binding protein, CMT2, and its role in mitosis , 2002, The EMBO journal.

[53]  Andrea Musacchio,et al.  Crystal structure of the tetrameric Mad1–Mad2 core complex: implications of a ‘safety belt’ binding mechanism for the spindle checkpoint , 2002, The EMBO journal.

[54]  K. Helin,et al.  Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint , 2001, The EMBO journal.

[55]  Emma Lees,et al.  Identification of an Overlapping Binding Domain on Cdc20 for Mad2 and Anaphase-Promoting Complex: Model for Spindle Checkpoint Regulation , 2001, Molecular and Cellular Biology.

[56]  J. Pines,et al.  Cyclin a Is Destroyed in Prometaphase and Can Delay Chromosome Alignment and Anaphase , 2001, The Journal of cell biology.

[57]  A. Murray,et al.  Visualization of Mad2 Dynamics at Kinetochores, along Spindle Fibers, and at Spindle Poles in Living Cells , 2000, The Journal of cell biology.

[58]  E. Koonin,et al.  The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. , 1998, Trends in biochemical sciences.

[59]  A Khodjakov,et al.  The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores , 1995, The Journal of cell biology.