Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.

[1]  C. Verlinde,et al.  Characterization of atrazine biotransformation by human and murine glutathione S-transferases. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[2]  D. Eaton,et al.  Biotransformation of methyl parathion by glutathione S-transferases. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[3]  N. Roodi,et al.  Sequential action of phase I and II enzymes cytochrome p450 1B1 and glutathione S-transferase P1 in mammary estrogen metabolism. , 2003, Cancer research.

[4]  M. Gross,et al.  Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3,4-quinone in vitro and in female ACI rat mammary gland in vivo. , 2003, Carcinogenesis.

[5]  Jane L Meza,et al.  Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer. , 2003, Carcinogenesis.

[6]  R. Kaaks,et al.  Obesity , Endogenous Hormones , and Endometrial Cancer Risk : A Synthetic Review 1 , 2002 .

[7]  V. Beral,et al.  Evidence from randomised trials on the long-term effects of hormone replacement therapy , 2002, The Lancet.

[8]  C. Ibarra,et al.  1.3‐Å resolution structure of human glutathione S‐transferase with S‐hexyl glutathione bound reveals possible extended ligandin binding site , 2002, Proteins.

[9]  Y. Awasthi,et al.  Role of α Class Glutathione S-Transferases as Antioxidant Enzymes in Rodent Tissues , 2002 .

[10]  J. Bolton,et al.  Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1. , 2002, Chemical research in toxicology.

[11]  U. Andley,et al.  Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2. , 2002, Investigative ophthalmology & visual science.

[12]  K. Kang,et al.  Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1* , 2001, The Journal of Biological Chemistry.

[13]  J. Bolton,et al.  Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin. , 2001, Biochemistry.

[14]  G. Chelvanayagam,et al.  Identification of novel glutathione transferases and polymorphic variants by expressed sequence tag database analysis. , 2001, Drug metabolism and disposition: the biological fate of chemicals.

[15]  G Chelvanayagam,et al.  Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases* , 2000, The Journal of Biological Chemistry.

[16]  K. Tew,et al.  Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases. , 2000, Cancer research.

[17]  James D. Yager,et al.  Chapter 3: Endogenous Estrogens as Carcinogens Through Metabolic Activation , 2000 .

[18]  J. Liehr.  Is Estradiol a Genotoxic Mutagenic Carcinogen ? * , 2000 .

[19]  J. Liehr,et al.  Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens. , 2000, Cancer research.

[20]  D. Eaton,et al.  Concise review of the glutathione S-transferases and their significance to toxicology. , 1999, Toxicological sciences : an official journal of the Society of Toxicology.

[21]  M. Pincus,et al.  Regulation of JNK signaling by GSTp , 1999, The EMBO journal.

[22]  J. Bolton,et al.  The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone. , 1999, Chemical research in toxicology.

[23]  M. Gross,et al.  Covalent binding of catechol estrogens to glutathione catalyzed by horseradish peroxidase, lactoperoxidase, or rat liver microsomes. , 1998, Chemical research in toxicology.

[24]  M. Gross,et al.  Synthesis and structure elucidation of estrogen quinones conjugated with cysteine, N-acetylcysteine, and glutathione. , 1998, Chemical research in toxicology.

[25]  J. Bolton,et al.  Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens. , 1998, Chemical research in toxicology.

[26]  E. Steegers,et al.  Glutathione S-transferases in human ovarian follicular fluid. , 1997, Fertility and sterility.

[27]  K. Patil,et al.  Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[28]  Colin McMartin,et al.  QXP: Powerful, rapid computer algorithms for structure-based drug design , 1997, J. Comput. Aided Mol. Des..

[29]  D. Berry,et al.  Relation of glutathione S-transferase α and μ isoforms to response to therapy in human breast cancer , 1997 .

[30]  J. Pezzuto,et al.  Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity. , 1997, Carcinogenesis.

[31]  J. Taylor,et al.  Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue. , 1996, The Biochemical journal.

[32]  M. Gross,et al.  Molecular characteristics of catechol estrogen quinones in reactions with deoxyribonucleosides. , 1996, Chemical research in toxicology.

[33]  M. Butterworth,et al.  17 beta-estradiol metabolism by hamster hepatic microsomes: comparison of catechol estrogen O-methylation with catechol estrogen oxidation and glutathione conjugation. , 1996, Chemical research in toxicology.

[34]  D. Meyer,et al.  Characterization of rat spleen prostaglandin H D-isomerase as a sigma-class GSH transferase. , 1995, The Biochemical journal.

[35]  J. Liehr,et al.  4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[36]  K. Kerlikowske,et al.  Hormone replacement therapy and endometrial cancer risk: a meta-analysis. , 1995, Obstetrics and gynecology.

[37]  R. Kretsinger,et al.  Crystal structure of human class mu glutathione transferase GSTM2-2. Effects of lattice packing on conformational heterogeneity. , 1994, Journal of molecular biology.

[38]  E. Cavalieri,et al.  Synthesis and characterization of estrogen 2,3- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens. , 1992, Chemical research in toxicology.

[39]  H. Strobel,et al.  Catalysis of the oxidation of steroid and stilbene estrogens to estrogen quinone metabolites by the beta-naphthoflavone-inducible cytochrome P450 IA family. , 1992, Archives of biochemistry and biophysics.

[40]  D. Harrison,et al.  Distribution of glutathione S-transferase isoenzymes in human ovary. , 1991, Journal of reproduction and fertility.

[41]  B. Ketterer,et al.  A novel glutathione transferase (13-13) isolated from the matrix of rat liver mitochondria having structural similarity to class theta enzymes. , 1991, The Biochemical journal.

[42]  P. van Bladeren,et al.  Irreversible inhibition of rat glutathione S-transferase 1-1 by quinones and their glutathione conjugates. Structure-activity relationship and mechanism. , 1991, The Biochemical journal.

[43]  B. Ketterer,et al.  Theta, a new class of glutathione transferases purified from rat and man. , 1991, The Biochemical journal.

[44]  Li Jj,et al.  Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism. , 1987 .

[45]  H. Strobel,et al.  Cytochrome P-450-mediated redox cycling of estrogens. , 1986, The Journal of biological chemistry.

[46]  H. Jörnvall,et al.  Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[47]  A. Hart,et al.  Non-protein bound oestradiol, sex hormone binding globulin, breast cancer and breast cancer risk. , 1985, British Journal of Cancer.

[48]  B. Ketterer,et al.  The Non‐Covalent Binding of Small Molecules by Ligandin , 1976 .

[49]  V. Cortes-gallegos,et al.  Estrogen peripheral levels vs estrogen tissue concentration in the human female reproductive tract. , 1975, Journal of steroid biochemistry.

[50]  D. Baird,et al.  CONCENTRATION OF OESTRONE AND OESTRADIOL IN FOLLICULAR FLUID AND OVARIAN VENOUS BLOOD OF WOMEN , 1975, Clinical endocrinology.

[51]  B. Ketterer,et al.  Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions , 1971, Nature.

[52]  P. Jellinck,et al.  Further evidence for the formation of an estrogen-peptide conjugate by rat liver in vitro. , 1967, Steroids.

[53]  W. Pearson,et al.  Distinctive structure of the human GSTM3 gene-inverted orientation relative to the mu class glutathione transferase gene cluster. , 1999, Archives of biochemistry and biophysics.

[54]  A. Conney,et al.  Functional role of estrogen metabolism in target cells: review and perspectives. , 1998, Carcinogenesis.

[55]  T. Monks,et al.  Toxicology of quinone-thioethers. , 1992, Critical reviews in toxicology.

[56]  W. Jakoby,et al.  Assays for differentiation of glutathione S-transferases. , 1981, Methods in enzymology.