Mechanisms of Asymmetric Stem Cell Division

[1]  K. White,et al.  Patterns of cell division and cell movement in the formation of the imaginal nervous system in Drosophila melanogaster. , 1978, Developmental biology.

[2]  M. Bate,et al.  Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster. , 1988, Developmental biology.

[3]  Ira Herskowitz,et al.  Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question , 1992, Cell.

[4]  Y. Hotta,et al.  Proliferation pattern of postembryonic neuroblasts in the brain of Drosophila melanogaster. , 1992, Developmental biology.

[5]  AC Tose.  Cell , 1993, Cell.

[6]  S. Zipursky,et al.  The Drosophila anachronism locus: A glycoprotein secreted by glia inhibits neuroblast proliferation , 1993, Cell.

[7]  Y. Jan,et al.  Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells , 1994, Cell.

[8]  S. Mcconnell,et al.  Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesis , 1995, Cell.

[9]  Y. Jan,et al.  Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis , 1996, Neuron.

[10]  Y. Jan,et al.  Role of inscuteable in orienting asymmetric cell divisions in Drosophila , 1996, Nature.

[11]  C. Doe,et al.  Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts , 1997, Current Biology.

[12]  D. Yamamoto,et al.  The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells. , 1997, Development.

[13]  W. Deng,et al.  Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila. , 1997, Developmental biology.

[14]  F. Slack,et al.  A novel repeat domain that is often associated with RING finger and B-box motifs. , 1998, Trends in biochemical sciences.

[15]  W. Chia,et al.  Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis. , 1998, Genes & development.

[16]  R. Bodmer,et al.  Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo , 1998, Mechanisms of Development.

[17]  Nicholas H. Brown,et al.  Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system , 1999, Nature Cell Biology.

[18]  A. Spradling,et al.  A niche maintaining germ line stem cells in the Drosophila ovary. , 2000, Science.

[19]  F. Matsuzaki,et al.  Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast , 2000, Nature.

[20]  C. Doe,et al.  The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts , 2000, Nature.

[21]  H. Vaessin,et al.  Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. , 2000, Genes & development.

[22]  T. Weissman,et al.  Neurons derived from radial glial cells establish radial units in neocortex , 2001, Nature.

[23]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.

[24]  H. Okano,et al.  Asymmetric Inheritance of Radial Glial Fibers by Cortical Neurons , 2001, Neuron.

[25]  R. Wharton,et al.  Drosophila Brain Tumor is a translational repressor. , 2001, Genes & development.

[26]  D. Berdnik,et al.  Drosophila Aurora-A Is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization during Mitosis , 2002, Current Biology.

[27]  B. Edgar,et al.  The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis. , 2002, Development.

[28]  Ting Xie,et al.  Germline Stem Cells Anchored by Adherens Junctions in the Drosophila Ovary Niches , 2002, Science.

[29]  S. Tazuke,et al.  Signaling from germ cells mediated by the rhomboid homolog stet organizes encapsulation by somatic support cells. , 2002, Development.

[30]  M. Gonzalez-Gaitan,et al.  The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. , 2002, Developmental cell.

[31]  S. Hirai,et al.  Association of ASIP/mPAR‐3 with adherens junctions of mouse neuroepithelial cells , 2002, Developmental dynamics : an official publication of the American Association of Anatomists.

[32]  Y. Jan,et al.  Progenitor cell maintenance requires numb and numblike during mouse neurogenesis , 2002, Nature.

[33]  Anjen Chenn,et al.  Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors , 2002, Science.

[34]  Pasko Rakic,et al.  Mitotic spindle rotation and mode of cell division in the developing telencephalon , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[35]  F. J. Livesey,et al.  Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina , 2003, Nature Genetics.

[36]  G. Fishell,et al.  Neurons from radial glia: the consequences of asymmetric inheritance , 2003, Current Opinion in Neurobiology.

[37]  C. Doe,et al.  Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry , 2003, Nature Cell Biology.

[38]  K. Mechtler,et al.  The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl , 2003, Nature.

[39]  F. Doetsch,et al.  The glial identity of neural stem cells , 2003, Nature Neuroscience.

[40]  T. Pawson,et al.  A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl , 2003, Nature Cell Biology.

[41]  Claudia S. Barros,et al.  Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport. , 2003, Developmental cell.

[42]  A. Suzuki,et al.  Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity , 2003, Current Biology.

[43]  Y. Jan,et al.  Inactivation of Numb and Numblike in Embryonic Dorsal Forebrain Impairs Neurogenesis and Disrupts Cortical Morphogenesis , 2003, Neuron.

[44]  W. Huttner,et al.  Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells , 2004, The EMBO journal.

[45]  Erich A Nigg,et al.  Aurora kinases link chromosome segregation and cell division to cancer susceptibility. , 2004, Current opinion in genetics & development.

[46]  J. Knoblich,et al.  Dare to Be Different: Asymmetric Cell Division in Drosophila, C. elegans and Vertebrates , 2004, Current Biology.

[47]  A. Kriegstein,et al.  Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases , 2004, Nature Neuroscience.

[48]  F. Schweisguth,et al.  Regulation of Notch Signaling Activity , 2004, Current Biology.

[49]  A. Spradling,et al.  Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries , 2004, Nature.

[50]  S. Tapscott,et al.  Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. , 2004, Genes & development.

[51]  Erich A. Nigg,et al.  Polo-like kinases and the orchestration of cell division , 2004, Nature Reviews Molecular Cell Biology.

[52]  F. Schweisguth,et al.  The roles of receptor and ligand endocytosis in regulating Notch signaling , 2005, Development.

[53]  F. Eisenhaber,et al.  Phosphorylation-Induced Autoinhibition Regulates the Cytoskeletal Protein Lethal (2) giant larvae , 2005, Current Biology.

[54]  S. Goderie,et al.  Asymmetric Distribution of EGFR Receptor during Mitosis Generates Diverse CNS Progenitor Cells , 2005, Neuron.

[55]  C. Doe,et al.  Microtubule-Induced Pins/Gαi Cortical Polarity in Drosophila Neuroblasts , 2005, Cell.

[56]  Tannishtha Reya,et al.  Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance , 2005, Nature Immunology.

[57]  M. Götz,et al.  The novel roles of glial cells revisited: the contribution of radial glia and astrocytes to neurogenesis. , 2005, Current topics in developmental biology.

[58]  S. Morrison,et al.  Supplemental Experimental Procedures , 2022 .

[59]  E. Caussinus,et al.  Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster , 2005, Nature Genetics.

[60]  L. Tsai,et al.  G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. , 2005, Cell.

[61]  B. Barres,et al.  Mammalian Inscuteable Regulates Spindle Orientation and Cell Fate in the Developing Retina , 2005, Neuron.

[62]  Linheng Li,et al.  Stem cell niche: structure and function. , 2005, Annual review of cell and developmental biology.

[63]  A. Spradling,et al.  The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals. , 2005, Developmental cell.

[64]  Juergen A. Knoblich,et al.  Quantitative Analysis of Protein Dynamics during Asymmetric Cell Division , 2005, Current Biology.

[65]  A. Hyman,et al.  Aurora A activates D-TACC–Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules , 2005, The Journal of cell biology.

[66]  T. Rando,et al.  The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis. , 2005, Seminars in cell & developmental biology.

[67]  Harrison W. Gabel,et al.  Functional Genomic Analysis of RNA Interference in C. elegans , 2005, Science.

[68]  L. Tsai,et al.  G Protein βγ Subunits and AGS3 Control Spindle Orientation and Asymmetric Cell Fate of Cerebral Cortical Progenitors , 2005, Cell.

[69]  Y. Jan,et al.  Drosophila Neuroblast Asymmetric Cell Division: Recent Advances and Implications for Stem Cell Biology , 2006, Neuron.

[70]  C. Doe,et al.  Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts , 2006, Development.

[71]  C. Doe,et al.  Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. , 2006, Genes & development.

[72]  K. Mechtler,et al.  Asymmetric Segregation of the Tumor Suppressor Brat Regulates Self-Renewal in Drosophila Neural Stem Cells , 2006, Cell.

[73]  T. Noda,et al.  Inactivation of aPKCλ results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex , 2006, Development.

[74]  A. Brand,et al.  Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. , 2006, Developmental cell.

[75]  S. Bowman,et al.  The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. , 2006, Developmental cell.

[76]  M. Götz,et al.  P-GAP-43 is enriched in horizontal cell divisions throughout rat cortical development. , 2006, Cerebral cortex.

[77]  J. Knoblich,et al.  Lethal giant larvae take on a life of their own. , 2006, Trends in cell biology.

[78]  Frank Hirth,et al.  The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila , 2006, Development.

[79]  M. Götz,et al.  The cell biology of neurogenesis , 2006, International Journal of Developmental Neuroscience.

[80]  Kristin J. Robinson,et al.  Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation , 2006, Nature.

[81]  C. Doe,et al.  Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. , 2006, Developmental cell.

[82]  Y. Jan,et al.  Postnatal Deletion of Numb/Numblike Reveals Repair and Remodeling Capacity in the Subventricular Neurogenic Niche , 2006, Cell.

[83]  N. Perrimon,et al.  Evidence that stem cells reside in the adult Drosophila midgut epithelium , 2006, Nature.

[84]  U. Heberlein,et al.  Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. , 2006, Genes & development.

[85]  A. Suzuki,et al.  The PAR-aPKC system: lessons in polarity , 2006, Journal of Cell Science.

[86]  Chris Q Doe,et al.  Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe , 2007, Neural Development.

[87]  C. Doe,et al.  The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts , 2006, Nature Cell Biology.

[88]  A. Spradling,et al.  The adult Drosophila posterior midgut is maintained by pluripotent stem cells , 2006, Nature.

[89]  T. Raabe,et al.  Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization , 2006, Nature Cell Biology.

[90]  John T. Chang,et al.  Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses , 2007, Science.

[91]  H. Macdonald,et al.  Normal Hemopoiesis and Lymphopoiesis in the Combined Absence of Numb and Numblike1 , 2007, The Journal of Immunology.

[92]  V. Hartenstein,et al.  A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors , 2007, Nature.

[93]  Monica Boyle,et al.  Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis. , 2007, Cell stem cell.

[94]  P. Thibault,et al.  aPKC‐mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb , 2007, The EMBO journal.

[95]  W. Huttner,et al.  Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1 , 2007, The Journal of cell biology.

[96]  Gerald B Call,et al.  Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary. , 2007, Cell stem cell.

[97]  Wei Liu,et al.  The adult Drosophila malpighian tubules are maintained by multipotent stem cells. , 2007, Cell stem cell.

[98]  W. Chia,et al.  Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon , 2007, Nature.

[99]  A. Spradling,et al.  Multipotent Drosophila Intestinal Stem Cells Specify Daughter Cell Fates by Differential Notch Signaling , 2007, Science.

[100]  M. Meister,et al.  Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre , 2007, Nature.

[101]  Bob Goldstein,et al.  The PAR proteins: fundamental players in animal cell polarization. , 2007, Developmental cell.

[102]  Cayetano Gonzalez.  Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells , 2007, Nature Reviews Genetics.

[103]  A. Spradling,et al.  Male and Female Drosophila Germline Stem Cells: Two Versions of Immortality , 2007, Science.

[104]  Y. Jan,et al.  Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors , 2007, Nature Neuroscience.

[105]  Tannishtha Reya,et al.  Imaging hematopoietic precursor division in real time. , 2007, Cell stem cell.

[106]  C. Gonzalez,et al.  Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells. , 2007, Developmental cell.

[107]  C. Doe,et al.  Gαi generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts , 2007, Proceedings of the National Academy of Sciences.

[108]  Timm Schroeder,et al.  Asymmetric cell division in normal and malignant hematopoietic precursor cells. , 2007, Cell stem cell.

[109]  M. Rudnicki,et al.  Asymmetric Self-Renewal and Commitment of Satellite Stem Cells in Muscle , 2007, Cell.

[110]  G. Cossu,et al.  Oriented Cell Divisions and Muscle Satellite Cell Heterogeneity , 2007, Cell.

[111]  C. Doe,et al.  Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6–aPKC , 2007, Journal of Cell Science.

[112]  M. Affolter,et al.  Self-renewal in the fly kidney. , 2007, Developmental cell.

[113]  M. Peifer,et al.  A role for a novel centrosome cycle in asymmetric cell division , 2007, The Journal of cell biology.

[114]  Hiroshi Kiyonari,et al.  Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis , 2008, Nature Cell Biology.

[115]  M. R. Costa,et al.  Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex , 2007, Development.