Fast dispersion encoded full range optical coherence tomography for retinal imaging at 800 nm and 1060 nm.

The dispersion mismatch between sample and reference arm in frequency-domain optical coherence tomography (OCT) can be used to iteratively suppress complex conjugate artifacts and thereby increase the imaging range. In this paper, we propose a fast dispersion encoded full range (DEFR) algorithm that detects multiple signal components per iteration. The influence of different dispersion levels on the reconstruction quality is analyzed experimentally using a multilayered scattering phantom and in vivo retinal tomograms at 800 nm. Best results have been achieved with 30 mm SF11, with neglectable resolution decrease due to finite resolution of the spectrometer. Our fast DEFR algorithm achieves an average suppression ratio of 55 dB and typically converges within 5 to 10 iterations. The processing time on non-dedicated hardware was 5 to 10 seconds for tomograms with 512 depth scans and 4096 sampling points per depth scan. Application of DEFR to the more challenging 1060 nm wavelength region is also demonstrated by introducing an additional optical fibre in the sample arm.

[1]  Richard G. Baraniuk,et al.  Sparse Signal Detection from Incoherent Projections , 2006, 2006 IEEE International Conference on Acoustics Speech and Signal Processing Proceedings.

[2]  Maciej Wojtkowski,et al.  Improved complex spectral domain OCT for in vivo eye imaging , 2005 .

[3]  Michael Pircher,et al.  Full range complex spectral domain optical coherence tomography without additional phase shifters. , 2007, Optics express.

[4]  B E Bouma,et al.  Elimination of depth degeneracy in optical frequency-domain imaging through polarization-based optical demodulation. , 2006, Optics letters.

[5]  R. Leitgeb,et al.  High speed full range complex spectral domain optical coherence tomography. , 2005, Optics express.

[6]  J. Duker,et al.  Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation. , 2004, Optics express.

[7]  Zhongping Chen,et al.  Removal of a mirror image and enhancement of the signal-to-noise ratio in Fourier-domain optical coherence tomography using an electro-optic phase modulator. , 2005, Optics letters.

[8]  Theo Lasser,et al.  Heterodyne Fourier domain optical coherence tomography for full range probing with high axial resolution. , 2006, Optics express.

[9]  Joseph A Izatt,et al.  Heterodyne swept-source optical coherence tomography for complete complex conjugate ambiguity removal. , 2005, Journal of biomedical optics.

[10]  Joseph A Izatt,et al.  High-speed complex conjugate resolved retinal spectral domain optical coherence tomography using sinusoidal phase modulation. , 2007, Optics letters.

[11]  Teresa C. Chen,et al.  Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography. , 2004, Optics express.

[12]  Daniel L Marks,et al.  Autofocus algorithm for dispersion correction in optical coherence tomography. , 2003, Applied optics.

[13]  Changhuei Yang,et al.  Instantaneous quadrature low coherence interferometry with 3 x 3 fiber optic couplers , 2003, Conference on Lasers and Electro-Optics, 2003. CLEO '03..

[14]  S. Yun,et al.  Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting. , 2004, Optics express.

[15]  R. Leitgeb,et al.  Complex ambiguity-free Fourier domain optical coherence tomography through transverse scanning. , 2007, Optics letters.

[16]  Angelika Unterhuber,et al.  Dispersion encoded full range frequency domain OCT , 2009, BiOS.

[17]  Changhuei Yang,et al.  Instantaneous complex conjugate resolved spectral domain and swept-source OCT using 3x3 fiber couplers. , 2005, Optics express.

[18]  Boris Hermann,et al.  Wide-field optical coherence tomography of the choroid in vivo. , 2008, Investigative ophthalmology & visual science.

[19]  A. Fercher,et al.  Full range complex spectral optical coherence tomography technique in eye imaging. , 2002, Optics letters.

[20]  T. Yatagai,et al.  Simultaneous B-M-mode scanning method for real-time full-range Fourier domain optical coherence tomography. , 2006, Applied optics.

[21]  Maciej Wojtkowski,et al.  Complex spectral OCT in human eye imaging in vivo , 2004 .

[22]  Theo Lasser,et al.  Dual beam heterodyne Fourier domain optical coherence tomography. , 2007, Optics express.

[23]  Ruikang K. Wang In vivo full range complex Fourier domain optical coherence tomography , 2007 .

[24]  Anna Szkulmowska,et al.  Flow velocity estimation by complex ambiguity free joint Spectral and Time domain Optical Coherence Tomography. , 2009, Optics express.

[25]  Kai Wang,et al.  Sinusoidal B-M method based spectral domain optical coherence tomography for the elimination of complex-conjugate artifact. , 2009, Optics express.

[26]  E. Peterman,et al.  Single-shot two-dimensional full-range optical coherence tomography achieved by dispersion control. , 2009, Optics express.

[27]  J. Izatt,et al.  Real-time quadrature projection complex conjugate resolved Fourier domain optical coherence tomography. , 2006, Optics letters.

[28]  W. Drexler,et al.  Dispersion encoded full range frequency domain optical coherence tomography. , 2009, Optics express.

[29]  Angelika Unterhuber,et al.  Signal post processing in frequency domain OCT and OCM using a filter bank approach , 2007, SPIE BiOS.

[30]  Y. Yasuno,et al.  Full-range, high-speed, high-resolution 1 microm spectral-domain optical coherence tomography using BM-scan for volumetric imaging of the human posterior eye. , 2008, Optics express.

[31]  W. Drexler,et al.  Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography. , 2009, Optics express.

[32]  W Drexler,et al.  Spectroscopic measurements with dispersion encoded full range frequency domain optical coherence tomography in single- and multilayered non-scattering phantoms. , 2009, Optics express.

[33]  A. Fercher,et al.  Phase-shifting algorithm to achieve high-speed long-depth-range probing by frequency-domain optical coherence tomography. , 2003, Optics letters.