An Automated Method for Levodopa-Induced Dyskinesia Detection and Severity Classification

In this paper we propose an automated method for Levodopa-induced dyskinesia (LID) detection and classifi- cation of its severity. The method is based on the analysis of the signals recorded from accelerometers which are placed on certain positions on the patient's body. The signals are ana- lyzed using a moving window and several features are ex- tracted. Based on these features a decision tree is used to detect if LID symptoms occur and classify them related to their se- verity. The method has been evaluated using a group of pa- tients and the obtained results indicate high classification ability (95% classification accuracy). Furthermore, extensive evaluation has been done in order to determine the optimal positioning of the sensors and the selection of the classification algorithm.

[1]  R. Roos,et al.  A review of the assessment of dyskinesias , 1999, Movement disorders : official journal of the Movement Disorder Society.

[2]  S. Gielen,et al.  Online monitoring of dyskinesia in patients with Parkinson's disease , 2003, IEEE Engineering in Medicine and Biology Magazine.

[3]  J W Langston,et al.  Quantification of dyskinesia in Parkinson's disease: Validation of a novel instrumental method , 1999, Movement disorders : official journal of the Movement Disorder Society.

[4]  Shouyan Wang,et al.  Quantifying drug-induced dyskinesias in the arms using digitised spiral-drawing tasks , 2005, Journal of Neuroscience Methods.

[5]  P Sainsbury,et al.  Ultrasound system for measuring patients' activity and disorders of movement. , 1972, Lancet.

[6]  Stan C A M Gielen,et al.  Movement parameters that distinguish between voluntary movements and levodopa-induced dyskinesia in Parkinson's disease. , 2003, Human movement science.

[7]  S. Fahn Members of the UPDRS Development Committee. Unified Parkinson's Disease Rating Scale , 1987 .

[8]  J. J. van Hilten,et al.  Accelerometric assessment of levodopa‐induced dyskinesias in Parkinson's disease , 2001, Movement disorders : official journal of the Movement Disorder Society.

[9]  S. Gielen,et al.  Automatic assessment of levodopa‐induced dyskinesias in daily life by neural networks , 2003, Movement disorders : official journal of the Movement Disorder Society.

[10]  C. Gielen,et al.  Detection and assessment of the severity of Levodopa‐induced dyskinesia in patients with Parkinson's disease by neural networks , 2000, Movement disorders : official journal of the Movement Disorder Society.