Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature

Complicated Old World cutaneous leishmaniasis (OWCL) and Old World mucosal leishmaniasis (OWML) constitute an indication for systemic treatment. To date, there no controlled clinical studies that compare treatment options for these diseases. We compiled a case series of 24 cases successfully treated with miltefosine. We conclude that oral miltefosine is an effective treatment option for both OWCL and OWML.

[1]  D. Lockwood,et al.  LeishMan recommendations for treatment of cutaneous and mucosal leishmaniasis in travelers, 2014. , 2014, Journal of travel medicine.

[2]  D. Lockwood,et al.  Clinical aspects and management of cutaneous leishmaniasis in rheumatoid patients treated with TNF-α antagonists. , 2013, Travel medicine and infectious disease.

[3]  M. Stoeckle,et al.  Treatment of mucosal leishmaniasis (L. infantum) with miltefosine in a patient with Good syndrome. , 2013, Acta tropica.

[4]  P. Tadrous,et al.  Lingual Leishmaniasis Presenting to Maxillofacial Surgery in UK with Successful Treatment with Miltefosine , 2013, Case reports in medicine.

[5]  C. Wendtner,et al.  Schwere orale Mukositis bei einem Patienten mit HIV-Infektion , 2013, Deutsche Medizinische Wochenschrift.

[6]  A. Neumayr,et al.  Cutaneous leishmaniasis in Switzerland: first experience with species-specific treatment , 2013, Infection.

[7]  M. Salam,et al.  Post-kala-azar Dermal Leishmaniasis with Mucosal Involvement: An Unusual Case Presentation including Successful Treatment with Miltefosine , 2013, Journal of health, population, and nutrition.

[8]  D. Lockwood,et al.  Local or systemic treatment for New World cutaneous leishmaniasis? Re-evaluating the evidence for the risk of mucosal leishmaniasis. , 2012, International health.

[9]  M. Stoeckle,et al.  Successful treatment of imported mucosal Leishmania infantum leishmaniasis with miltefosine after severe hypokalemia under meglumine antimoniate treatment. , 2012, Journal of travel medicine.

[10]  J. Beijnen,et al.  Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine , 2011, PLoS neglected tropical diseases.

[11]  M. Ephros,et al.  Liposomal amphotericin B treatment of cutaneous leishmaniasis due to Leishmania tropica , 2011, Journal of the European Academy of Dermatology and Venereology : JEADV.

[12]  D. Häussinger,et al.  Mucosal Leishmania infantum infection , 2011, Parasitology Research.

[13]  H. Auer,et al.  Cutaneous leishmaniasis after travel to Cyprus and successful treatment with miltefosine. , 2011, The American journal of tropical medicine and hygiene.

[14]  A. Müller,et al.  Resolution of Cutaneous Old World and New World Leishmaniasis after Oral Miltefosine Treatment , 2010, The American journal of tropical medicine and hygiene.

[15]  P. D. de Vries,et al.  Miltefosine treatment of Leishmania major infection: an observational study involving Dutch military personnel returning from northern Afghanistan. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[16]  J. Bogner,et al.  Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab. , 2009, The American journal of tropical medicine and hygiene.

[17]  P. Kager,et al.  Cutaneous leishmaniasis with lymphadenopathy due to Leishmania donovani , 2009, Clinical and experimental dermatology.

[18]  R. Davidson,et al.  Miltefosine to treat cutaneous leishmaniasis caused by Leishmania tropica , 2009, Annals of tropical medicine and parasitology.

[19]  D. Krahl,et al.  Cutaneous infection with Leishmania infantum in an infant treated successfully with miltefosine , 2008, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[20]  A. Fotouhi,et al.  Comparison of miltefosine and meglumine antimoniate for the treatment of zoonotic cutaneous leishmaniasis (ZCL) by a randomized clinical trial in Iran. , 2007, Acta tropica.

[21]  T. Junghanss,et al.  First case of typical Old World cutaneous leishmaniasis treated with miltefosine , 2007, International journal of dermatology.

[22]  S. Rahman,et al.  Miltefosine in cutaneous leishmaniasis. , 2007, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.

[23]  F. Pratlong,et al.  Healing of Old World cutaneous leishmaniasis in travelers treated with fluconazole: drug effect or spontaneous evolution? , 2007, The American journal of tropical medicine and hygiene.

[24]  H. Günthard,et al.  Successful treatment with miltefosine of disseminated cutaneous leishmaniasis in a severely immunocompromised patient infected with HIV-1. , 2005, Clinical Infectious Diseases.