Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.

[1]  Shuichi Tsutsumi,et al.  ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif , 2011, Nucleic acids research.

[2]  B. Blanco-Sánchez,et al.  BMP signaling orchestrates photoreceptor specification in the zebrafish pineal gland in collaboration with Notch , 2011, Development.

[3]  J. Hao,et al.  Distinct Signaling Pathways Regulate Sprouting Angiogenesis from the Dorsal Aorta and Axial Vein , 2011, Nature Cell Biology.

[4]  R. Simon,et al.  Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies. , 2011, Cancer research.

[5]  H. Gerhardt,et al.  Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting , 2010, Nature Cell Biology.

[6]  R. Adams,et al.  Dynamics of endothelial cell behavior in sprouting angiogenesis. , 2010, Current opinion in cell biology.

[7]  Marie-José Goumans,et al.  Signaling by members of the TGF-beta family in vascular morphogenesis and disease. , 2010, Trends in cell biology.

[8]  Ryoichiro Kageyama,et al.  Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling , 2010, Genes to cells : devoted to molecular & cellular mechanisms.

[9]  C. Lindsley,et al.  In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. , 2010, ACS chemical biology.

[10]  Paul A. Bates,et al.  Tipping the Balance: Robustness of Tip Cell Selection, Migration and Fusion in Angiogenesis , 2009, PLoS Comput. Biol..

[11]  Ryoichiro Kageyama,et al.  The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. , 2009, Genes & development.

[12]  L. David,et al.  Emerging role of bone morphogenetic proteins in angiogenesis. , 2009, Cytokine & growth factor reviews.

[13]  Peter Carmeliet,et al.  Mechanisms of Vessel Branching: Filopodia on Endothelial Tip Cells Lead the Way , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[14]  C. Mummery,et al.  Real time monitoring of BMP Smads transcriptional activity during mouse development , 2008, Genesis.

[15]  Ryoichiro Kageyama,et al.  Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors , 2008, Neuron.

[16]  Adrian L Harris,et al.  Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. , 2008, Microvascular research.

[17]  C. Patterson,et al.  Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors , 2007, The Journal of cell biology.

[18]  Ryoichiro Kageyama,et al.  Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. , 2007, Developmental cell.

[19]  Ryoichiro Kageyama,et al.  Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum , 2007, Proceedings of the National Academy of Sciences.

[20]  D. Huylebroeck,et al.  Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. , 2007, The American journal of pathology.

[21]  Adam L. Bermange,et al.  Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis , 2007, Development.

[22]  G. Thurston,et al.  Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting , 2007, Proceedings of the National Academy of Sciences.

[23]  Holger Gerhardt,et al.  Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis , 2007, Nature.

[24]  Nathan D. Lawson,et al.  Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries , 2007, Nature.

[25]  Gavin Thurston,et al.  Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis , 2006, Nature.

[26]  Minhong Yan,et al.  Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis , 2006, Nature.

[27]  M. Holderfield,et al.  HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes. , 2006, Biochemical and biophysical research communications.

[28]  M. Goumans,et al.  Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells , 2004, The EMBO journal.

[29]  U. Lendahl,et al.  Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation , 2003, Development.

[30]  D. Huylebroeck,et al.  Generation of a floxed allele of Smad5 for cre‐mediated conditional knockout in the mouse , 2003, Genesis.

[31]  K. Alitalo,et al.  VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia , 2003, The Journal of cell biology.

[32]  M. Goumans,et al.  Stimulation of Id1 Expression by Bone Morphogenetic Protein Is Sufficient and Necessary for Bone Morphogenetic Protein–Induced Activation of Endothelial Cells , 2002, Circulation.

[33]  Holger Gerhardt,et al.  Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. , 2002, Genes & development.

[34]  E. Hara,et al.  Id proteins in cell cycle control and cellular senescence , 2001, Oncogene.

[35]  C. Deng,et al.  Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion. , 2001, Developmental biology.

[36]  E. Robertson,et al.  Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. , 2001, Development.

[37]  Shur-Jen Wang,et al.  The Basic Helix-Loop-Helix Transcription Factor HESR1 Regulates Endothelial Cell Tube Formation* , 2001, The Journal of Biological Chemistry.

[38]  R. Hammer,et al.  Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. , 2001, Developmental biology.

[39]  W. Gerald,et al.  Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts , 1999, Nature.

[40]  M. Matzuk,et al.  Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. , 1999, Development.

[41]  C. Deng,et al.  Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. , 1999, Development.

[42]  J. Norton,et al.  Coupling of Cell Growth Control and Apoptosis Functions of Id Proteins , 1998, Molecular and Cellular Biology.

[43]  Philippe Soriano.  Generalized lacZ expression with the ROSA26 Cre reporter strain , 1999, Nature Genetics.