Brain activity during source memory retrieval in young, middle-aged and old adults

We investigated neurofunctional changes associated with source memory decline across the adult life span using functional magnetic resonance imaging (fMRI). Young, middle-aged and old adults carried out a natural/artificial judgment of images of common objects that were randomly presented in one of the quadrants of the screen. At retrieval, the images were displayed at the center of the screen and the participants judged whether each image was new or old and, if old, they indicated in which quadrant of the screen the image had originally been presented. Comparing the items associated with correct versus incorrect source judgments revealed that no regions showed greater activity in young adults than in middle-aged adults; however, in young and middle-aged adults the activity in the left hippocampus and left anterior temporal cortex was of greater magnitude than in the older adults. Several regions also exhibited greater activity in young adults than in old adults. These results suggest that in middle age the recollection neural network, assessable by fMRI, is still preserved.

[1]  I. Olson,et al.  The Enigmatic temporal pole: a review of findings on social and emotional processing. , 2007, Brain : a journal of neurology.

[2]  Yasuyuki Taki,et al.  Effects of Aging on Hippocampal and Anterior Temporal Activations during Successful Retrieval of Memory for Face–Name Associations , 2011, Journal of Cognitive Neuroscience.

[3]  Roberto Cabeza,et al.  Effects of healthy aging on hippocampal and rhinal memory functions: an event-related fMRI study. , 2005, Cerebral cortex.

[4]  Anthony R. McIntosh,et al.  Age-Related Differences in Neural Activity during Memory Encoding and Retrieval: A Positron Emission Tomography Study , 1997, The Journal of Neuroscience.

[5]  B. Winblad,et al.  Brain Activation in Young and Older Adults During Implicit and Explicit Retrieval , 1997, Journal of Cognitive Neuroscience.

[6]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[7]  A. Yonelinas.  The Nature of Recollection and Familiarity: A Review of 30 Years of Research , 2002 .

[8]  M. Rajah,et al.  Age-related changes in prefrontal cortex activity are associated with behavioural deficits in both temporal and spatial context memory retrieval in older adults , 2010, Cortex.

[9]  T. Mäntylä,et al.  Acting or listening: Adult age differences in source recall of enacted and nonenacted statements , 1996 .

[10]  Kaia L. Vilberg,et al.  Brain Networks Underlying Episodic Memory Retrieval This Review Comes from a Themed Issue on Macrocircuits Memory Signals within the Mtl , 2022 .

[11]  K. Brodmann.  Vergleichende Lokalisationslehre der Großhirnrinde : in ihren Prinzipien dargestellt auf Grund des Zellenbaues , 1985 .

[12]  Marcia K. Johnson,et al.  Source monitoring 15 years later: what have we learned from fMRI about the neural mechanisms of source memory? , 2009, Psychological bulletin.

[13]  Ian M. McDonough,et al.  Memory's aging echo: Age-related decline in neural reactivation of perceptual details during recollection , 2014, NeuroImage.

[14]  T. Mäntylä,et al.  Adult age differences in source recall: a population-based study. , 1996, The journals of gerontology. Series B, Psychological sciences and social sciences.

[15]  Marcia K. Johnson,et al.  Age-related differences in agenda-driven monitoring of format and task information , 2013, Neuropsychologia.

[16]  Heekyeong Park,et al.  An fMRI study of episodic encoding across the lifespan: Changes in subsequent memory effects are evident by middle-age , 2013, Neuropsychologia.

[17]  Armin Schnider,et al.  Spontaneous confabulators fail to suppress currently irrelevant memory traces , 1999, Nature Neuroscience.

[18]  Lars Nyberg,et al.  Age-Related Differences in Neural Activity during Item and Temporal-Order Memory Retrieval: A Positron Emission Tomography Study , 2000, Journal of Cognitive Neuroscience.

[19]  Karl J. Friston,et al.  Classical and Bayesian Inference in Neuroimaging: Theory , 2002, NeuroImage.

[20]  Ian M. McDonough,et al.  Age-related differences in prefrontal cortex activity during retrieval monitoring: testing the compensation and dysfunction accounts. , 2013, Cerebral cortex.

[21]  R. Cabeza,et al.  Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval. , 2004, Cerebral cortex.

[22]  Julia Spaniol,et al.  Aging and the neural correlates of source memory: over-recruitment and functional reorganization , 2012, Neurobiology of Aging.

[23]  M. Rugg,et al.  Age effects on brain activity associated with episodic memory retrieval. An electrophysiological study. , 1998, Brain : a journal of neurology.

[24]  Roberto Cabeza,et al.  Prefrontal and medial temporal lobe contributions to relational memory in young and older adults , 2006, Handbook of Binding and Memory.

[25]  Cinthya Estrada-Manilla,et al.  fMRI subsequent source memory effects in young, middle-aged and old adults , 2015, Behavioural Brain Research.

[26]  P. Graf,et al.  Episodic spatial memory in adulthood. , 1993, Psychology and aging.

[27]  John Ashburner,et al.  A fast diffeomorphic image registration algorithm , 2007, NeuroImage.

[28]  Roberto Cabeza,et al.  Aging Gracefully: Compensatory Brain Activity in High-Performing Older Adults , 2002, NeuroImage.

[29]  E. Balteau,et al.  Differential effects of aging on the neural correlates of recollection and familiarity , 2013, Cortex.

[30]  Tania Gómez-Fernández,et al.  The rate of source memory decline across the adult life span. , 2013, Developmental psychology.

[31]  Pierre Maquet,et al.  Brain activity underlying encoding and retrieval of source memory. , 2002, Cerebral cortex.

[32]  David Friedman,et al.  Age-related changes in source memory retrieval: an ERP replication and extension. , 2002, Brain research. Cognitive brain research.

[33]  M. Moscovitch,et al.  The parietal cortex and episodic memory: an attentional account , 2008, Nature Reviews Neuroscience.

[34]  P W Burgess,et al.  Confabulation and the control of recollection. , 1996, Memory.

[35]  Audrey Duarte,et al.  The effects of aging on material-independent and material-dependent neural correlates of source memory retrieval. , 2012, Cerebral cortex.

[36]  R. Kawashima,et al.  The Role of the Basal Forebrain in Episodic Memory Retrieval: A Positron Emission Tomography Study , 2002, NeuroImage.

[37]  R. Turner,et al.  Event-Related fMRI: Characterizing Differential Responses , 1998, NeuroImage.

[38]  Malcolm W. Brown,et al.  Recognition memory: What are the roles of the perirhinal cortex and hippocampus? , 2001, Nature Reviews Neuroscience.

[39]  Cara L. Wong,et al.  The function of the anterior temporal lobe: A review of the empirical evidence , 2012, Brain Research.

[40]  Morris Moscovitch,et al.  Strategic retrieval and the frontal lobes: Evidence from confabulation and amnesia , 1997, Neuropsychologia.

[41]  M. Rugg,et al.  Age effects on the neural correlates of episodic retrieval: increased cortical recruitment with matched performance. , 2007, Cerebral cortex.

[42]  Rachel A. Diana,et al.  Imaging recollection and familiarity in the medial temporal lobe: a three-component model , 2007, Trends in Cognitive Sciences.

[43]  Selene Cansino,et al.  Neural correlates of source memory retrieval in young, middle-aged and elderly adults , 2012, Biological Psychology.

[44]  Y. Miyashita.  Inferior temporal cortex: where visual perception meets memory. , 1993, Annual review of neuroscience.

[45]  Gordon Jackson-Koku,et al.  Beck Depression Inventory. , 2016, Occupational medicine.

[46]  Morris Moscovitch,et al.  Mechanisms of spontaneous confabulations: a strategic retrieval account. , 2006, Brain : a journal of neurology.

[47]  J. G. Snodgrass,et al.  Pragmatics of measuring recognition memory: applications to dementia and amnesia. , 1988, Journal of experimental psychology. General.

[48]  J. Aggleton.  Multiple anatomical systems embedded within the primate medial temporal lobe: Implications for hippocampal function , 2012, Neuroscience & Biobehavioral Reviews.

[49]  M. D. Rugg,et al.  Regional specificity of age effects on the neural correlates of episodic retrieval , 2008, Neurobiology of Aging.

[50]  N. Raz,et al.  Differential effects of aging on memory for content and context: a meta-analysis. , 1995, Psychology and aging.

[51]  R. Henson,et al.  The Effects of Aging on the Neural Correlates of Subjective and Objective Recollection , 2007, Cerebral cortex.

[52]  Anthony R. McIntosh,et al.  Age-related Changes in Brain Activity across the Adult Lifespan , 2006 .

[53]  Gereon R. Fink,et al.  Ageing-related changes of neural activity associated with spatial contextual memory , 2009, Neurobiology of Aging.

[54]  F. Craik,et al.  Age differences in recall and recognition , 1987 .

[55]  G. Mandler.  Recognizing: The judgment of previous occurrence. , 1980 .

[56]  Martin Lepage,et al.  Dorsolateral prefrontal cortex involvement in memory post-retrieval monitoring revealed in both item and associative recognition tests , 2005, NeuroImage.